Creation of intelligent nanocarrier by effector-function elaboration to polymer materials
| Project/Area Number |
23300179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
HARADA Atsushi 大阪府立大学, 工学(系)研究科(研究院), 准教授 (50302774)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 遺伝子治療 / ナノキャリア / 多分岐ポリエチレングリコール / ポリ-L-リシン / ナノファイバーポリプレックス / 遺伝子ベクター / ポリプレックス / エフェクター効果 / 高分子材料 / エフェクター機能 / DNA凝縮 |
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| Research Abstract |
The functional elaborations including stability in serum medium, cellular uptake, cellular distribution and transcription / translation process are important in the development of the gene vector. Many studies have been performed for these subjects, but there are only a few reports on the promotion of efficiency of a transcription process yet. In this study, we developed the polymeric materials that could exhibit effective a transcription / the translation efficiency and also clarify the mechanism for these materials. Furthermore, we achieved the effective gene expression through the combination of the developed polymeric materials with cationic lipids.
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Report
(4 results)
Research Products
(26 results)
