| Project/Area Number |
23300181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Defense Medical College |
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Principal Investigator |
ISHIHARA Masayuki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 教授 (10508500)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Miya 防衛医科大学校, 医学教育部医学科専門課程, 教授 (30505342)
MAEHARA Masaaki 防衛医科大学校, 医学教育部医学科専門課程, 教授 (70124956)
KIYOSAWA Tomoharu 防衛医科大学校, 病院, 准教授 (90221217)
藤田 真敬 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 准教授 (20525927)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 生体材料 / 生物・生体工学 / ナノ材料 / 移植・再生医療 / 再生医学 |
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| Research Abstract |
Fragmin/protamine micro/nanoparticles (F/P M/NPs) were evaluated as a carrier for growth factors such as FGF and HGF and PRP (platelet-rich plasma) derived functional proteins. In addition, F/P M/NPs in combination with adipose-derived stromal cells (ASCs), are a new convenient cell carrier and may be a promising novel therapy for inducing vascularization and healing healing-impaired wounds in ischemic disease by transplantation of the ASCs/F/P M/NPs s-aggregates. Thus, LMW-H/P MPs are an excellent carrier for GFs and various cells such as ASCs. Clinical research was performed using autologous PRP/F/P M/NPs. Hair growth and thickening following the administration was observed in all patients compared with the control and its efficiency and safety were demonstrated.
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