| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Research Abstract |
F-DPPC for high PFC was newly synthesized as shell of BL. Fluorinated phospholipid (F-DPPC) was synthesized as a new outer shell material of BL for the purpose of retention of PFC. RGD-BL (DSPC:F-DPPC:DSPE-PEG2000:DSPE-PEG3000-Mal=44:50:5:1 (molar ratio)) encapsulating mixed gas of C5F12:C6F14=1:1 (weight ratio), was prepared with about 500 nm in diameter. The combination of RGD-BL and diagnostic US make the image of the thrombus and neovasculature of solid tumor. The combination of RGD-BL and therapeutic US can be use for gene therapy by introduction of pCMV-IL12 and hyperthermia treatment with intratumoral temperature rise. Thus, the combination of RGD-BL and US may be used for ultrasound theranostics system with therapeutic and diagnostic, which is a next-generation.
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