Mechanism of pleiotropic effects of exercise training in inter-organ communication
| Project/Area Number |
23300196
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
OSAMU Ito 東北大学, 医学(系)研究科(研究院), 准教授 (00361072)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Nobuyoshi 東北大学, 大学院・医学系研究科, 助教 (50463790)
KOHZUKI Masahiro 東北大学, 大学院・医学系研究科, 教授 (70234698)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | リハビリテーション / 臓器連関 / 腎臓 / 循環器・高血圧 / 酸化ストレス / 組織・細胞 / 動物 |
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| Research Abstract |
The impacts of inhibitors of NADPH oxidase and xanthine oxidase in the exercise training (Ex)-increased nitric oxide (NO) synthase (NOS) activity and expression were examined in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs). Ex-increased NOS activity and expression in aorta were mediated through NADPH oxidase in both SHRs and WKYs. The Ex-induced NOS activity and expression in kidney were mediated through NADPH oxidase in WKYs but through xanthine oxidase in SHRs.
In Dahl salt-sensitive rats, Ex improves high salt-induced renal damage in the blood pressure-independent manner with changes of oxidative stress, NO system, renin-angiotensin system, and arachidonic acid metabolism in the kidney.
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Report
(4 results)
Research Products
(115 results)
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[Journal Article] Effect of cardiac rehabilitation on exercise tolerance, instrumental activities of daily living (IADL) and Quality of Life (QOL) in severe heart failure treated with implantable left ventricular assist device (LVAD)2013
Author(s)
Suzuki F, Ito O, Mori N, Takahashi T, Sakata Y, Nagasaka M, Ebihara S, Nakatomi C, Minamishima D, Nikkuni Y, Akiyama M, Kawamoto S, Saiki Y, Kohzuki M
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Journal Title
Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine
Volume: 7
Pages: 141-142
Related Report
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[Journal Article] 植込み型補助人工心臓（LVAD）を装着した重症心不全への心臓リハビリテーションの効果2013
Author(s)
鈴木文歌, 伊藤 修, 森 信芳, 高橋珠緒，坂田佳子，長坂 誠，海老原覚, 仲冨千瑞, 南島大輔, 新國悦弘, 秋山正年, 川本俊介, 齋木佳克, 上月正博
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Journal Title
運動器リハビリテーション
Volume: 24
Pages: 65-71
NAID
Related Report
Peer Reviewed
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[Journal Article] 5/6 腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSF の併用療法による腎保護効果2011
Author(s)
須田千尋, 金澤雅之, 姚 強, 高島健太, 坂田佳子, 室谷嘉一, 森 信芳, 長坂誠, 海老原覚, 伊藤 修, 上月正博
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Journal Title
運動療法と物理療法
Volume: 22
Pages: 78-84
NAID
Related Report
Peer Reviewed
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[Presentation] 5/6 腎摘除慢性腎不全モデルラットにおける, 長期的運動とG-CSFの併用療法が及ぼす腎保護効果2012
Author(s)
須田千尋, 金澤雅之, 高島健太, 田村由馬, 坂田佳子, 森 信芳, 長坂 誠, 海老原覚, 伊藤 修, 上月正博
Organizer
第2回日本腎臓リハビリテーション学会
Place of Presentation
仙台
Year and Date
2012-01-20
Related Report
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[Presentation] 心腎連関2011
Author(s)
伊藤 修
Organizer
日本循環器看護学会
Place of Presentation
仙台
Year and Date
2011-11-12
Related Report
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[Presentation] 5/6 腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSF の併用療法による腎保護効果2011
Author(s)
須田千尋, 金澤雅之, 姚 強, 高島健太, 坂田佳子, 室谷嘉一, 森 信芳, 長坂誠, 海老原覚, 伊藤 修, 上月正博
Organizer
第34回日本高血圧学会
Place of Presentation
宇都宮
Year and Date
2011-10-21
Related Report
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[Presentation] Exercise training increases nitric oxide synthases in the kidney of rats with chronic heart failure2011
Author(s)
Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Rong R, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
Organizer
65th Annual Fall Conference and Scientific Session of the Council for High Blood Pressure Research
Place of Presentation
Orland, USA
Year and Date
2011-09-22
Related Report
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[Presentation] Combination of chronic exercise and G-CSF protects renal function in chronic renal failure (CRF) rats2011
Author(s)
Suda T, Kanazawa M, Yao Q, Takashima K, Sakata Y, Muroya Y, Mori N, Nagasaka M, Ebihara S, Ito O, Kohzuki M
Organizer
6th World Congress of the International Society of Physical and Rehabilitation Medicine
Place of Presentation
San Juan, Puerto Rico
Year and Date
2011-06-13
Related Report
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