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Neural basis for human bipedal locomotion -a study relevant to neurorehabilitation-

Research Project

Project/Area Number 23300198
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAZAWA Kimitaka  東京大学, 総合文化研究科, 教授 (90360677)

Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Keywords歩行 / 脊髄損傷 / リハビリテーション / 脊髄運動ニューロン / 脊髄 / 運動制御
Outline of Final Research Achievements

The final goal of this study is to reveal both structure and function of locomotor spinal neural circuits in human. To aproach this goal, passive stepping in water, functional spinal map, and multisegmental motor responses were studied. The results showed that load information might play an important role to facilitate spinal neural circuits(SNC), while somatosensory information related to lower limb kinematics might have inhibitory effect on the SNC. The functional spinal map suggested that the lowre limb muscular activities might be provided from the spinal locomotor circuits that span widely from the lower thoracic levels to the higher lumber level.

Report

(4 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (33 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Invited: 13 results)

  • [Journal Article] Velocity-dependent H-reflex suppression of the soleus muscle during robot-assisted passive stepping.2015

    • Author(s)
      Yohei Masugi, Taku Kitamura, Kiyotaka Kamibayashi, Tetsuya Ogawa, Toru Ogata, Noritaka Kawashima, Kimitaka Nakazawa
    • Journal Title

      Neuroscience Letters

      Volume: 584 Pages: 337-341

    • DOI

      10.1016/j.neulet.2014.10.044

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhythmic arm swing enhances patterned locomotor-like muscle activity in passively moved lower extremities.2015

    • Author(s)
      Tetsuya Ogawa, Takahiko Sato, Toru Ogata, Shin-Ichiro Yamamoto, Kimitaka Nakazawa, Noritaka Kawashima
    • Journal Title

      Physiological Reports

      Volume: 3(3) Issue: 3 Pages: e12317-e12317

    • DOI

      10.14814/phy2.12317

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct motor strategies underlying split-belt adaptation in human walking and running.2015

    • Author(s)
      Tetsuya Ogawa, Noritaka Kawashima, Hiroki Obata, Kazuyuki Kanosue, Kimitaka Nakazawa
    • Journal Title

      PLoS ONE

      Volume: 10(3) Issue: 3 Pages: e0121951-e0121951

    • DOI

      10.1371/journal.pone.0121951

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heel strike detection using split force-plate treadmill.2015

    • Author(s)
      Rouhani, H, Abe O, Nakazawa K, Popovic MR, Masani K.
    • Journal Title

      Gait & Posture

      Volume: 41(3) Pages: 863-866

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Mechanical and neural changes in plantar-flexor muscles after spinal cord injury in humans.2015

    • Author(s)
      Yaeshima K, Negishi D, Yamamoto S, Ogata T, Nakazawa K, Kawashima N.
    • Journal Title

      Spinal Cord

      Volume: Feb 10 Issue: 7 Pages: 526-533

    • DOI

      10.1038/sc.2015.9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歩行と脊髄制御2014

    • Author(s)
      中澤公孝、一寸木洋平
    • Journal Title

      Annual Review神経2014

      Volume: 1 Pages: 1-8

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 姿勢制御と発育・発達2014

    • Author(s)
      山本暁生、中澤公孝
    • Journal Title

      バイオメカニクス研究

      Volume: 18-1 Pages: 23-30

    • Related Report
      2013 Annual Research Report
  • [Journal Article] ロコモーションパターンの形成と遷移を司る神経制御機構2014

    • Author(s)
      横山 光、中澤公孝
    • Journal Title

      バイオメカニクス研究

      Volume: 18-2 Pages: 40-52

    • NAID

      40020212506

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Adapted physical activityの可能性と課題2014

    • Author(s)
      中澤公孝
    • Journal Title

      体育の科学

      Volume: 64 Pages: 391-395

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 脳神経機能のトレーニングとディトレーニング-運動記憶の忘却に打ち勝つための神経メカニズム-2014

    • Author(s)
      横山 光、中澤公孝
    • Journal Title

      体育の科学

      Volume: 64 Pages: 673-679

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Neural control of muscle lengthening: Task- and musclespecificity.2013

    • Author(s)
      Sekiguchi H, K. Nakazawa, T. Hortobágyi
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 2 Pages: 191-202

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 思った通りにからだを動かす”能力を取り戻すリハビリ2013

    • Author(s)
      中澤公孝
    • Journal Title

      バイオメカニクス研究

      Volume: 17-3 Pages: 160-165

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Neural control of human gait and posture2012

    • Author(s)
      Nakazawa K, Obata H, Sasagawa S
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 1(2) Pages: 263-269

    • NAID

      10031158953

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limited transfer of newly acquired movement patterns across walking and running in humans.2012

    • Author(s)
      Ogawa T, Kawashima N, Ogata T, Nakazawa K
    • Journal Title

      PLoS One

      Volume: 7 Issue: 9 Pages: e46349-e46349

    • DOI

      10.1371/journal.pone.0046349

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetrical neural adaptation in lower leg muscles as a consequence of stereotypical motor training.2012

    • Author(s)
      Ogawa T, Kawashima N, Suzuki S, Nakazawa K
    • Journal Title

      J Motor Behav

      Volume: 44(1) Issue: 1 Pages: 63-68

    • DOI

      10.1080/00222895.2011.645912

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 水中リハビリテーションの今後の展望2011

    • Author(s)
      中澤公孝
    • Journal Title

      体育の科学

      Volume: 61 Pages: 285-287

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 水中歩行の運動生理学的特性2011

    • Author(s)
      福崎千穂、中澤公孝
    • Journal Title

      体育の科学

      Volume: 61 Pages: 211-215

    • Related Report
      2011 Annual Research Report
  • [Journal Article] ロコマットを活用した脊髄損傷者の歩行再建2011

    • Author(s)
      中澤公孝
    • Journal Title

      福祉介護機器

      Volume: 4 Pages: 16-22

    • Related Report
      2011 Annual Research Report
  • [Presentation] Locomotor Neurorehabilitation -Past and future direction-2015

    • Author(s)
      中澤公孝
    • Organizer
      International symposium on Hybrid Organs of the future, The Center for Advanced Medical Engineering and Informatics
    • Place of Presentation
      大阪府、吹田市、大阪大学臨床医工学融合研究教育センター
    • Year and Date
      2015-03-03
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 歩行ニューロリハビリテーションの最先端とスポーツの可能性―最新の研究動向から―2014

    • Author(s)
      中澤公孝
    • Organizer
      脳神経科学研究会
    • Place of Presentation
      長野県、鹿教湯温泉、鹿教湯リハビリテーション病院
    • Year and Date
      2014-08-30
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] スポーツの認知神経科学2014

    • Author(s)
      中澤公孝
    • Organizer
      時間学セミナーin慶應
    • Place of Presentation
      神奈川県、横浜市、慶応大学
    • Year and Date
      2014-08-11
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アダプテッドスポーツの理論と実際―水中ポールウォークの紹介―2014

    • Author(s)
      中澤公孝
    • Organizer
      日本スイミングクラブ協会講演会
    • Place of Presentation
      東京都、江東区、YMCA
    • Year and Date
      2014-07-13
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 歩行ニューロリハビリテーションの可能性―最新の研究動向から―2014

    • Author(s)
      中澤公孝
    • Organizer
      脳神経科学研究会
    • Place of Presentation
      大阪府、大阪市、大阪保健福祉専門学校
    • Year and Date
      2014-04-19
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 歩行のニューロリハビリテーション-臨床的応用-2013

    • Author(s)
      中澤公孝
    • Organizer
      生体計測応用研究会
    • Place of Presentation
      東京都、大田区、東京工科大
    • Year and Date
      2013-11-09
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神経の可塑性と脊髄損傷のリハビリテーション2013

    • Author(s)
      中澤公孝
    • Organizer
      日本生理人類学会
    • Place of Presentation
      京都府、京田辺市、同志社大学
    • Year and Date
      2013-10-26
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アダプテッドスポーツの可能性と今日的課題2013

    • Author(s)
      中澤公孝
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      東京都、千代田区、日本教育会館
    • Year and Date
      2013-09-21
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 歩行ニューロリハビリテーションの可能性2013

    • Author(s)
      中澤公孝
    • Organizer
      脳神経科学セミナー
    • Place of Presentation
      長野県、鹿教湯温泉、鹿教湯リハビリテーション病院
    • Year and Date
      2013-08-24
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effects of Sensory Input on Spinal and Corticospinal Excitabilities During Robot-Assisted Stepping.2013

    • Author(s)
      中澤公孝
    • Organizer
      nd Joint World Congress of ISPGR and Gait and Mental Function
    • Place of Presentation
      秋田県、秋田市、秋田ビューホテル
    • Year and Date
      2013-06-22
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effects of peripheral sensory information on corticospinal and spinal reflex excitabilities during robotically assisted stepping2012

    • Author(s)
      Kimitaka Nakazawa
    • Organizer
      Anual Assembly of Liaoning Academy of Physical Medicine and Rehabilitation
    • Place of Presentation
      西安、中国
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 他動ステッピングに伴う末梢感覚入力が脊髄反射系に与える短期可塑的効果2011

    • Author(s)
      中澤公孝
    • Organizer
      第50回生体医工学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of somatosensory information on corticospinal and spinal reflex excitabilities during robotically assisted stepping2011

    • Author(s)
      中澤公孝
    • Organizer
      FICCDAT Conference
    • Place of Presentation
      トロント(カナダ)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歩行ニューロリハビリテーションの基礎

    • Author(s)
      中澤公孝
    • Organizer
      鹿教湯神経脳科学セミナー
    • Place of Presentation
      鹿教湯リハビリテーション病院(上田)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 免荷歩行トレーニングの神経生理

    • Author(s)
      中澤公孝
    • Organizer
      日本臨床神経生理学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2011-04-06   Modified: 2019-07-29  

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