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Studies to assess the neural basis of constraint-induced movement therapy (CIMT) which is intensive therapy for hemiparetic upper extremities in stroke patients: diffusion tensor imaging studies

Research Project

Project/Area Number 23300203
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHyogo Medical University

Principal Investigator

DOMEN Kazuhisa  兵庫医科大学, 医学部, 教授 (50207685)

Co-Investigator(Kenkyū-buntansha) MARUMOTO Kohei  兵庫医科大学, 医学部, 助教 (80594738)
FURUKAWA Keiko  兵庫医科大学, 医学部, 助教 (10412016)
HOSOMI Masashi  兵庫医科大学, 医学部, 助教 (30517397)
KODAMA Norihiko  兵庫医科大学, 医学部, 講師 (40278833)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
KeywordsCI療法 / 脳卒中 / 拡散テンソル画像 / 予後予測 / 運動学習 / ニューロリハビリテーション / 片麻痺 / 上肢機能 / 学習性不使用 / 可塑性
Research Abstract

To test whether diffusion tensor imaging could evaluate potential motor capability of patients with chronic cerebral infarction. We used constraint-induced movement therapy (CIMT) as a rehabilitation, which reveals potential motor capability. We also investigated the relationship between the outcome of CIMT and the ratio between fractional anisotropy values (rFA) in affected and unaffected sites of the corticospinal tract before CIMT. Imaging was performed in cerebral infarction patients and the rFA of the posterior limb of internal capsule (PLIC) was measured before CIMT. Patients were evaluated before and after CIMT using the Fugl-Meyer (F-M) assessment,Wolf Motor Function Test, and Motor Activity Log. All patients showed an improvement in mobility following the 10-day CIMT session. Strong positive correlation was found only between F-M after CIMT and PLIC-rFA (r = 0.8098, p = 0.0004).These data support PLIC-rFA as a new marker of the CIMT-induced improvement in motor function.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report

Research Products

(18 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (14 results)

  • [Journal Article] Diffusion tensor imaging predicts the outcome of constraint-induced movement therapy in chronic infarction patients with hemiplegia : A pilot study2013

    • Author(s)
      Marumoto K, Koyama T, Hosomi M, Takebayashi T, Hanada K, Ikeda S, Kodama N, Domen K
    • Journal Title

      Restorative Neurology and Neuroscience

      Volume: 31(4) Pages: 387-396

    • DOI

      10.3233/rnn-120285

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between diffusion tensor fractional anisotropy and motor outcome in patients with hemiparesis after corona radiata infarct2013

    • Author(s)
      Koyama T, Marumoto K, Miyake H, Domen K
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 22(8) Pages: 1355-60

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.02.017

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between diffusion-tensor fractional anisotropy and long-term outcome in patients with hemiparesis after intracerebral hemorrhage2013

    • Author(s)
      Koyama T, Marumoto K, Miyake H, Ohmura T, Domen K
    • Journal Title

      NeuroRehabilitation

      Volume: 32(1) Pages: 87-94

    • DOI

      10.3233/nre-130825

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A 6-month follow-up after constraint-induced movement therapy with and without transfer package for patients with hemiparesis after stroke : a pilot quasi-randomized controlled trial2013

    • Author(s)
      Takebayashi T, Koyama T, Amano S, Hanada K, Tabusadani M, Hosomi M, Marumoto K, Takahashi K, Domen K
    • Journal Title

      Clin Rehabil.

      Volume: 27(5) Pages: 418-26

    • DOI

      10.1177/0269215512460779

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Constraint-induced movement therapy に長期効果をもたらすTransfer package の神経基盤の探索2014

    • Author(s)
      竹林 崇, 花田恵介, 丸本 浩平, 小山哲男, 道免 和久
    • Organizer
      第5回日本ニューロリハビリテーション学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Constraint-induced movement therapyに長期効果をもたらすTransfer packageの神経基盤の探索2014

    • Author(s)
      竹林 崇, 花田恵介, 丸本 浩平, 小山哲男, 道免 和久
    • Organizer
      第5回日本ニューロリハビリテーション学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] MRI 拡散テンソル法(DTI) FA 値と脳梗塞片麻痺症状の関連2013

    • Author(s)
      小山 哲男, 丸本 浩平, 道免 和久
    • Organizer
      第50回日本リハビリテーション学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] MRI拡散テンソル法(DTI) FA値と脳梗塞片麻痺症状の関連2013

    • Author(s)
      小山 哲男, 丸本 浩平, 道免 和久
    • Organizer
      第50回日本リハビリテーション学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Year Follow-up after Constraint-induced Movement therapy in chronic stroke patients with Clinical outcome evaluation: pilot prospective self-controlled trial2013

    • Author(s)
      竹林 崇
    • Organizer
      2nd JAPAN-korea NeuroRehabilitation Conference
    • Place of Presentation
      岡山
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multidisciplinary intervention for severe chronic upper extremity motor impairment:A case report2013

    • Author(s)
      花田 恵介
    • Organizer
      2nd JAPAN-korea NeuroRehabilitation Conference
    • Place of Presentation
      岡山
    • Related Report
      2012 Annual Research Report
  • [Presentation] Introduction of Constraint-Induced Movement Therapy in Japan : a 10-Year Review2012

    • Author(s)
      道免和久
    • Organizer
      The 1st Korea-Japan, Neurorehabilitation Conference
    • Place of Presentation
      韓国
    • Year and Date
      2012-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Long- Term Effective of Transfer Package in Modified Constraint-Induced Movement Therapy2012

    • Author(s)
      竹林 崇, 道免 和久
    • Organizer
      The 1st Korea-Japan Neurorehabilitation Conference
    • Place of Presentation
      韓国
    • Year and Date
      2012-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Does Constraint-Induced Movement Therapy Improve Lower-Extremity Deficits After Stroke?2012

    • Author(s)
      花田恵介, 道免和久
    • Organizer
      The 1st Korea-Japan Neurorehabilitation Conference
    • Place of Presentation
      韓国
    • Year and Date
      2012-03-17
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Introduction of Constraint-Induced Movement Therapy in Japan : a 10-Year Review2012

    • Author(s)
      道免和久
    • Organizer
      The 1st Korea-Japan Neurorehabilitation Conference
    • Place of Presentation
      韓国
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Long-Term Effective of Transfer Package in Modified Constraint-Induced Movement Therapy2012

    • Author(s)
      竹林崇
    • Organizer
      The 1st Korea-Japan Neurorehabilitation Conference
    • Place of Presentation
      韓国
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Diffusion Tensor Imaging (DTI)を使用した慢性期脳梗塞患者のlearned nonuseの評価2012

    • Author(s)
      丸本 浩平
    • Organizer
      第49回日本リハビリテーション医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Constraint-induced movement therapy(CI 療法)の拡散テンソル画像による神経基盤研究2011

    • Author(s)
      丸本浩平
    • Organizer
      第48回日本リハビリテーション医学会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Constraint-induced movement therapy(CI療法)の拡散テンソル画像による神経基盤研究2011

    • Author(s)
      丸本浩平
    • Organizer
      第48回日本リハビリテーション医学会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-05   Modified: 2019-07-29  

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