| Project/Area Number |
23300217
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical education
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
MATSUKAWA Kanji 広島大学, 医歯薬保健学研究院(保), 教授 (90165788)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAN Nobusuke 山口大学, 教育学部, 教授 (00179920)
KOMINE Hidehiko 独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 研究員 (10392614)
SADAMOTO Tomoko 日本女子体育大学, 体育学部, 教授 (30201528)
HAMAOKA Takafumi 立命館大学, スポーツ健康科学部, 教授 (70266518)
LIANG Nan 広島大学, 医歯薬保健学研究院(保), 助教 (70512515)
|
|---|
| Research Collaborator |
ENDO Kana 広島大学, 医歯薬保健学研究院(保), 助教
ISHII Kei 広島大学, 医歯薬保健学研究科(保), 大学院生
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|
|---|
| Keywords | セントラルコマンド / 脳活動の計測 / 循環調節 / 随意運動 / スポーツ科学 / リハビリテーション / 運動の精神イメージ / 中枢性循環調節 / 大脳皮質 / 中脳腹側被蓋野 / 動脈血圧反射 |
|---|
| Research Abstract |
We conducted human and animal studies to explore neural mechanisims of generating central command responsible for feedforward control of circulation during exercise. When measuring cerebral cortical activity with near infrared spectroscopy at various sites of the frontal lobe in humans, prefrontal activity increased preceding the exercise onset while motor areas never showed such activity. Animal study was performed to examine whether neural circuits in the brainstem, particularly the midbrain ventral tegmental area (VTA), may play a role in generating central command. Injection of a GABA antagonist into VTA increased renal sympathetic outflow and blood pressure and caused rhythmic motor nerve discharges, whereas injection of a GABA agonist stopped spontaneous motor activity. Blood flow and c-fos expression in VTA increased during spontaneous motor activity. Thus it is likely that an increase in prefrontal activity triggers neural circuits in VTA to generate central command.
|
