| Project/Area Number |
23300237
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Kanazawa University |
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Principal Investigator |
MASUDA Kazumi 金沢大学, 人間科学系, 教授 (50323283)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAKURA Hisashi 同志社大学, スポーツ健康科学部, 助教 (20631914)
IWANAKA Nobumasa 立命館大学, グローバル イノベーション研究機構, 研究員(博士研究員) (80584002)
HASHIMOTO Takeshi 立命館大学, スポーツ健康科学部, 准教授 (70511608)
HAYANO Toshiya 立命館大学, 生命科学部, 教授 (90332303)
HANAI Yoshiteru 名古屋工業大学, 工学研究科, 准教授 (50360730)
KATO Yukio 金沢大学, 薬学系, 教授 (30251440)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 筋細胞 / 運動 / 代謝 / ミトコンドリア / ミオグロビン / 相互作用 |
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| Research Abstract |
Cellular respiration is influenced by a wide range of mechanisms including the response of the cardiovascular and metabolic systems to meet the changing energy demands in muscle. The present focused on myoglobin (Mb), an important cellular O2 binding protein that is expressed in skeletal and cardiac muscle cells, and set a hypothesis that Mb will have a direct interaction with the mitochondrial respiration. The present study using rodent hindlimb muscles and cultured myoblast (L6), obtained evidences that Mb directly co-localized on mitochondria within a myocytes. Unexpectedly, Mb presences in mitochondria. The mitochondrial Mb can interact with complex IV to facilitated O2 consumption in mitochondria. Further investigation must be necessary to clarify the target proteins of Mb within mitochondria to obtain the new physiological functions of the mitochondrial Mb in myocytes.
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