Systemic elucidation of central regulation system under physical fatigue

• Project/Area Number: 23300241
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Osaka City University
• Principal Investigator: TANAKA MASAAKI 大阪市立大学, 医学(系)研究科(研究院), 講師 (60382199)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: スポーツ生理学 / 疲労 / 脳磁図 / 身体的疲労 / パフォーマンス / ストレス / 精神的疲労 / 古典的条件付け / 背側前頭前野

Outline of Final Research Achievements

The purpose of this study was to elucidate a physical regulation system in the central nervous system under the condition of fatigue using functional brain imaging techniques from the viewpoint of fatigue, inhibition system, facilitation system, and fatigue sensation. By using magnetoencephalography, neural substrates of inhibition system (dorsolateral prefrontal cortex), facilitation system (dorsolateral prefrontal cortex), and fatigue sensation (posterior cingulate cortex). On the other hand, I proved that the classical conditioning of physical fatigue could take place (posterior cingulate cortex) and identified the neural mechanisms to cause chronic fatigue using the magnetoencephalography.

Research Products

• [Journal Article] Fatigue in the central nervous system (2015)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Austin J Clin Neurol Volume: 2 Pages: 1020-1020
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hazardous effects of light stimulation in the central nervous system (2014)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Austin J Clin Neurol Volume: 2 Pages: 1010-1010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Regulatory mechanism of performance in chronic cognitive fatigue (2014)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Med Hypotheses Volume: 82 Issue: 5 Pages: 567-571
  • DOI: 10.1016/j.mehy.2014.02.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural effects of mental fatigue caused by continuous attention load: A magnetoencephalography study (2014)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Brain Res Volume: 1561 Pages: 60-66
  • DOI: 10.1016/j.brainres.2014.03.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural effect of mental fatigue on physical fatigue: A magnetoencephalography study (2014)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Brain Res Volume: 1542 Pages: 49-55
  • DOI: 10.1016/j.brainres.2013.10.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural dysfunction in chronic fatigue syndrome (2013)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Advances in Neuroimmune Biology Volume: 4 Pages: 291-300
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural mechanisms underlying chronic fatigue (2013)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Rev Neurosci Volume: 24 Issue: 6 Pages: 917-628
  • DOI: 10.1515/revneuro-2013-0035
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural mechanism of facilitation system during physical fatigue (2013)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: PLoS One Volume: 8 Issue: 11 Pages: 80731-80731
  • DOI: 10.1371/journal.pone.0080731
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural mechanism of central inhibition during physical fatigue: A magnetoencephalography study (2013)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Brain Res Volume: 1537 Pages: 117-124
  • DOI: 10.1016/j.brainres.2013.08.054
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural correlates of central inhibition during physical fatigue (2013)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: PLoS One Volume: 8 Issue: 7 Pages: 70949-70949
  • DOI: 10.1371/journal.pone.0070949
  • Open Access
• [Journal Article] Fatigue-recovering effect of a house designed with open space. (2013)
  • Author(s): Tanaka, M., Yamada, H., Nakamura, T., Ishii, A., Watanabe, Y.
  • Journal Title: Explore (NY) Volume: 9(2) Issue: 2 Pages: 82-86
  • DOI: 10.1016/j.explore.2012.12.006
  • Peer Reviewed
• [Journal Article] Two different types of mental fatigue produce different styles of task performance. (2013)
  • Author(s): Shigihara, Y., Tanaka, M., Ishii, A., Tajima, S., Kanai, E., Funakura, M., Watanabe, Y.
  • Journal Title: Neurol Psychiatr Brain Res Volume: 9(1) Issue: 1 Pages: 5-11
  • DOI: 10.1016/j.npbr.2012.07.002
  • Peer Reviewed
• [Journal Article] Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways. (2013)
  • Author(s): Shigihara, Y., Tanaka, M., Ishii, A., Kanai, E., Funakura, M., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 9(1) Issue: 1 Pages: 2-2
  • DOI: 10.1186/1744-9081-9-2
  • Peer Reviewed
• [Journal Article] Risk-management syndrome. (2012)
  • Author(s): Tanaka, M., Watanabe, Y.
  • Journal Title: Int J Psychiatry Clin Pract Volume: 16(4) Issue: 4 Pages: 312-315
  • DOI: 10.3109/13651501.2011.653378
  • Peer Reviewed
• [Journal Article] Supraspinal regulation of physical fatigue. (2012)
  • Author(s): Tanaka, M., Watanabe, Y.
  • Journal Title: Neurosci Biobehav Rev Volume: 36(1) Issue: 1 Pages: 727-734
  • DOI: 10.1016/j.neubiorev.2011.10.004
  • Peer Reviewed
• [Journal Article] Cognitive dysfunction in elderly females with depressive symptoms. (2012)
  • Author(s): Tanaka, M., Ishii, A., Yamano, E., Ogikubo, H., Okazaki, M., Kamimura, K., Konishi, Y., Emoto, S., Watanabe, Y.
  • Journal Title: Med Sci Monit Volume: 18(12) Pages: 706-711
  • Peer Reviewed
• [Journal Article] Impaired selective attention caused by mental fatigue. (2012)
  • Author(s): Tanaka, M., Ishii, A., Shigihara, Y., Tajima, S., Funakura, M., Kanai, E., Watanabe, Y.
  • Journal Title: J Neurol Sci (Turkish) Volume: 29(3) Pages: 542-553
  • Peer Reviewed
• [Journal Article] Validation of the Japanese version of the power of food scale in a young adult population. (2012)
  • Author(s): Yoshikawa, T., Orita, K., Watanabe, Y., Tanaka, M.
  • Journal Title: Psychol Rep Volume: 111(1) Pages: 253-265
  • Peer Reviewed
• [Journal Article] Effect of mental fatigue on the central nervous system: an electroencephalography study. (2012)
  • Author(s): Tanaka, M., Shigihara, Y., Ishii, A., Funakura, M., Kanai, E., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 8(1) Issue: 1 Pages: 48-48
  • DOI: 10.1186/1744-9081-8-48
  • Peer Reviewed
• [Journal Article] Effect of a human-type communication robot on cognitive function in elderly females living alone. (2012)
  • Author(s): Tanaka, M., Ishii, A., Yamano, E., Ogikubo, H., Okazaki, M., Kamimura, K., Konishi, Y., Emoto, S., Watanabe, Y.
  • Journal Title: Med Sci Monit Volume: 18(9) Pages: 550-559
  • Peer Reviewed
• [Journal Article] The neural substrates associated with attentional resources and difficulty of concurrent processing of the two verbal tasks. (2012)
  • Author(s): Mizuno, K., Tanaka, M., Tanabe, H.C., Sadato, N., Watanabe, Y.
  • Journal Title: Neuropsychologia Volume: 50(8) Issue: 8 Pages: 1998-2009
  • DOI: 10.1016/j.neuropsychologia.2012.04.025
  • Peer Reviewed
• [Journal Article] Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers. (2012)
  • Author(s): Kuratsune, D., Tajima, S., Koizumi, J., Yamaguti, K., Sasabe, T., Mizuno, K., Tanaka, M., Okawa, N., Mito, H., Tsubone, H., Watanabe, Y., Inoue, M., Kuratsune, H.
  • Journal Title: World J Neurosci Volume: 2(2) Pages: 113-118
  • Peer Reviewed
• [Journal Article] Effects of daily levels of fatigue and acutely induced fatigue on the visual evoked magnetic response. (2012)
  • Author(s): Shigihara, Y., Tanaka, M., Mizuno, K., Ishii, A., Yamano, E., Funakura, M., Kanai, E., Watanabe, Y.
  • Journal Title: Brain Res Volume: 1457 Pages: 44-50
  • DOI: 10.1016/j.brainres.2012.03.056
  • Peer Reviewed
• [Journal Article] Positron emission tomography (PET) imaging-based evaluation of hepatobiliary transport in humans using 15R-[^<11>C]TIC-Me (2012)
  • Author(s): Tadayuki Takashima, Satoshi Kitamura, Yasuhiro Wada, Masaaki Tanaka, Yoshihito Shigihara, Hideki Ishii, Ryosuke Ijuin, Susumu Shiomi, Takahiro Nakae, Yumiko Watanabe, Yilong Cui, Hisashi Doi, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
  • Journal Title: J. Nucl. Med. Volume: 53 Issue: 5 Pages: 741-748
  • DOI: 10.2967/jnumed.111.098681
  • Peer Reviewed
• [Journal Article] Neural substrates activated by viewing others expressing fatigue: revealed by magnetoencephalography. (2012)
  • Author(s): Ishii, A., Tanaka, M., Yamano, E., Watanabe, Y.
  • Journal Title: Brain Res Volume: 1455 Pages: 68-74
  • DOI: 10.1016/j.brainres.2012.03.031
  • Peer Reviewed
• [Journal Article] Fatigue-associated alterations of cognitive function and electroencephalographic power densities. (2012)
  • Author(s): Tanaka, M., Shigihara, Y., Funakura, M., Kanai, E., Watanabe, Y.
  • Journal Title: PLoS One Volume: 7(4) Issue: 4 Pages: 34774-34774
  • DOI: 10.1371/journal.pone.0034774
  • Peer Reviewed
• [Journal Article] Academic and family conditions associated with intrinsic academic motivation in Japanese medical students: a pilot study. (2012)
  • Author(s): Tanaka, M., Watanabe, Y.
  • Journal Title: Health Educ J Volume: 71(3) Issue: 3 Pages: 358-364
  • DOI: 10.1177/0017896911401004
  • Peer Reviewed
• [Journal Article] Association between lifestyle and school attendance in Japanese medical students: a pilot study. (2012)
  • Author(s): Tanaka, M., Watanabe, Y.
  • Journal Title: Health Educ J Volume: 71(2) Issue: 2 Pages: 165-172
  • DOI: 10.1177/0017896910393788
  • Peer Reviewed
• [Journal Article] Imaging of gastrointestinal absorption and biodistribution of an orally administered probe using positron emission tomography in humans. (2012)
  • Author(s): Shingaki, T., Takashima, T., Wada Y, Tanaka, M., Kataoka, M., Ishii, A., Shigihara, Y., Sugiyama, Y., Yamashita, S., Watanabe, Y.
  • Journal Title: Clin Pharmacol Ther Volume: 91(4) Issue: 4 Pages: 653-659
  • DOI: 10.1038/clpt.2011.267
  • Peer Reviewed
• [Journal Article] Effects of pellet stove on recovery from mental fatigue. (2012)
  • Author(s): Tanaka, M., Yamada, H., Nakamura, T., Watanabe, Y.
  • Journal Title: Med Sci Monit Volume: 18(3) Pages: 148-153
  • Peer Reviewed
• [Journal Article] Autonomic nervous alterations associated with daily level of fatigue. (2011)
  • Author(s): Tanaka, M., Mizuno, K., Yamaguti, K., Kuratsune, H., Fujii, A., Baba, H., Matsuda, K., Nishimae, A., Takesaka, T., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 7 Issue: 1 Pages: 46-46
  • DOI: 10.1186/1744-9081-7-46
  • Peer Reviewed
• [Journal Article] Central inhibition regulates motor output during physical fatigue. (2011)
  • Author(s): Tanaka, M., Shigihara, Y., Watanabe, Y.
  • Journal Title: Brain Res Volume: 1412 Pages: 37-43
  • DOI: 10.1016/j.brainres.2011.07.021
  • Peer Reviewed
• [Journal Article] Gustatory imagery reveals functional connectivity from the prefrontal to insular cortices traced with magnetoencephalography (2011)
  • Author(s): Kobayashi M
  • Journal Title: PLoS ONE Volume: 6 Issue: 7 Pages: 21736-21736
  • DOI: 10.1371/journal.pone.0021736
  • Peer Reviewed
• [Journal Article] Low visual information-processing speed and attention are predictors of fatigue in elementary and junior high school students. (2011)
  • Author(s): Mizuno, K., Tanaka, M., Fukuda, S., Yamano, E., Shigihara, Y., Imai-Matsumura, K., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 7 Issue: 1 Pages: 20-20
  • DOI: 10.1186/1744-9081-7-20
  • Peer Reviewed
• [Journal Article] Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity. (2011)
  • Author(s): Mizuno, K., Tanaka, M., Yamaguti, K., Kajimoto, O., Kuratsune, H., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 7 Issue: 1 Pages: 17-17
  • DOI: 10.1186/1744-9081-7-17
  • Peer Reviewed
• [Journal Article] Neural compensation mechanisms to regulate motor output during physical fatigue. (2011)
  • Author(s): Tanaka, M., Watanabe, Y.
  • Journal Title: Brain Res Volume: 1935 Pages: 46-52
  • DOI: 10.1016/j.brainres.2011.04.041
  • Peer Reviewed
• [Journal Article] Relationship between cognitive functions and prevalence of fatigue in elementary and junior high school students. (2011)
  • Author(s): Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K., Watanabe, Y.
  • Journal Title: Brain Dev Volume: 33 Issue: 6 Pages: 470-479
  • DOI: 10.1016/j.braindev.2010.08.012
  • NAID: 10029561992
  • Peer Reviewed
• [Journal Article] Central regulation of physical fatigue via mirror visual feedback. (2011)
  • Author(s): Tsutsumi, K., Tanaka, M., Shigihara, Y., Watanabe, Y.
  • Journal Title: Eur J Sport Sci Volume: 11 Pages: 171-175
  • Peer Reviewed
• [Journal Article] Changes in cognitive functions of students in the transitional period from elementary school to junior high school. (2011)
  • Author(s): Mizuno, K., Tanaka, M., Fukuda, S., Sasabe, T., Imai-Matsumura, K., Watanabe, Y.
  • Journal Title: Brain Dev Volume: 33 Issue: 5 Pages: 412-420
  • DOI: 10.1016/j.braindev.2010.07.005
  • NAID: 10029561733
  • Peer Reviewed
• [Journal Article] Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents. (2011)
  • Author(s): Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 7 Issue: 1 Pages: 4-4
  • DOI: 10.1186/1744-9081-7-4
  • Peer Reviewed
• [Presentation] 疲労と自律神経機能・睡眠・リズム障害 (2015)
  • Author(s): 田中雅彰、石井聡、山野恵美、渡辺恭良
  • Organizer: 第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県・神戸市）
  • Year and Date: 2015-03-23
• [Presentation] 脳磁図を用いた疲労の脳科学研究 (2014)
  • Author(s): 田中雅彰、石井聡、山野恵美、渡辺恭良
  • Organizer: 第10回日本疲労学会総会・学術集会
  • Place of Presentation: グランフロント大阪内コングレコンベンションセンター（大阪府・大阪市）
  • Year and Date: 2014-05-30
• [Presentation] 疲労の脳磁図研究 (2013)
  • Author(s): 田中雅彰、石井聡、山野恵美、渡辺恭良
  • Organizer: 第9回日本疲労学会総会・学術集会
  • Place of Presentation: 秋田県総合保健センター（秋田県・秋田市）
  • Year and Date: 2013-06-07
• [Presentation] The neural mechanisms of the phonemic restoration in people with normal hearing. (2013)
  • Author(s): Sunami, K., Ishii, A., Tanaka, M., Watanabe, Y., Sakasita, T., Yamamoto, H., Yamane, H.
  • Organizer: 36th MidWinter Meeting, Association for Research in Otolaryngology
  • Place of Presentation: Baltimore, USA
• [Presentation] 慢性疲労の中枢神経系機構解明を目指した脳磁図研究 (2012)
  • Author(s): 田中雅彰、石井聡、山野恵美、渡辺恭良
  • Organizer: 第8回日本疲労学会総会・学術集会
  • Place of Presentation: 国立スポーツ科学センター
  • Invited
• [Presentation] 脳磁図計測による疲労の中枢神経系メカニズムの解明 (2012)
  • Author(s): 石井聡、田中雅彰、山野恵美、渡辺恭良
  • Organizer: 第8回日本疲労学会総会・学術集会
  • Place of Presentation: 国立スポーツ科学センター
  • Invited
• [Presentation] Neural substrates of central inhibition during physical fatigue. (2012)
  • Author(s): 田中雅彰、石井聡、山野恵美、渡辺恭良
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Imaging brain aromatase in human with [11C]cetrozole. (2012)
  • Author(s): Takahashi, K., Hosoya, T., Takashima, T., Tanaka, M., Ishii, A., Nakatomi, Y., Tazawa, S., Takahashi, K., Doi, H., Watanabe, Y., Wada, Y., Suzuki, M., Onoe, H., Watanabe, Y.
  • Organizer: World Molecular Imaging Congress (WMIC) 2012
  • Place of Presentation: Dublin, Ireland
• [Presentation] 脳磁図解析により新しく発見した疲労の神径メカニズム (2011)
  • Author(s): 田中雅彰、鴫原良仁、石井聡、山野恵美、渡辺恭良
  • Organizer: 第7回日本疲労学会総会・学術集会
  • Place of Presentation: 名古屋大学
  • Invited
• [Presentation] 新規aromataseイメージングPETプローブ (2011)
  • Author(s): 高橋佳代、細谷孝充、尾上嘉代、長田浩子、土居久志、和田康弘、高島忠之、田村泰久、渡辺由美子、田中雅彰、石井聡、鈴木正昭、尾上浩隆、渡辺恭良
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸国際会議場
  • Invited
• [Presentation] Use of positron emission tomography for the analysis of gastrointestinal drug absorption in human. (2011)
  • Author(s): Takashima, T., Shingaki, T., Tanaka, M., Shigihara, Y., Wada, Y., Kataoka, M., Sugiyama, Y., Yamashita, S., Watanabe, Y.
  • Organizer: World Molecular Imaging Congress (WMIC) 2011
  • Place of Presentation: San Diego, USA