Exercise prescription based on the circadian rhythm of adipocyte clock genes : The significance of chrono-exercise prescription

• Project/Area Number: 23300242
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Doshisha University
• Principal Investigator: IZAWA Tetsuya 同志社大学, スポーツ健康科学部, 教授 (70147495)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 脂肪細胞 / 時計遺伝子 / 運動 / アディポカイン / 脂肪分解反応 / 脂肪組織

Research Abstract

The mRNA levels of both adipokines and metabolic genes were strongly correlated with those of clock genes. The mRNA expressions of adipokines and metabolic genes, which were obtained after the exercise performed at the peak of Bmal1 mRNA expression, differed from those obtained after the exercise performed at the bottom of Bmal1 mRNA expression. Melatonin affected the mRNA expressions of several genes regulating adipocyte metabolism and adipokines. The findings indicate that the circadian rhythm of adipokines genes and metabolic genes should be considered when the exercise is used for preventing and improving metabolic syndrome due to obesity.

Research Products

• [Journal Article] ETAS, an enzyme-treated asparagus extract, attenuates amyloid beta-induced cellular disorder in PC12 cells (2014)
  • Author(s): Ogasawara J, Ito T, Wakame K, Kitadate K, Sakurai T, Sato S, Ishibashi Y, Izawa T, Takahashi K, Ishida H, Takabatake I, Kizaki T, Ohno H
  • Journal Title: Nat Prod Commun Volume: 9 Pages: 561-564
  • Peer Reviewed
• [Journal Article] A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression (2014)
  • Author(s): Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T
  • Journal Title: J Immunol Volume: 192 Pages: 407-417
  • Peer Reviewed
• [Journal Article] A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression. (2014)
  • Author(s): Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
  • Journal Title: J Immunol. Volume: 192 Issue: 1 Pages: 407-417
  • DOI: 10.4049/jimmunol.1301982
  • Peer Reviewed / Open Access
• [Journal Article] 脂肪分解反応を制御する新しいプレーヤーと運動の影響(総説) (2013)
  • Author(s): 井澤鉄也
  • Journal Title: 医学のあゆみ Volume: 244 Pages: 1068-1073
• [Journal Article] The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue (2013)
  • Author(s): Sakurai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Takahashi M, Kobayashi O, Oh-Ishi S, Nagasawa J, Takahashi K, Ishida H, Izawa T, Ohno H
  • Journal Title: Int J Endocrinol Volume: 2013 Pages: 801743-801743
  • Peer Reviewed
• [Journal Article] Role of nitric oxide in muscle regeneration following eccentric muscle contractions in rat skeletal muscle (2013)
  • Author(s): Sakurai T, Kashimura O, Kano Y, Ohno H, Ji LL, Izawa T, Best TM
  • Journal Title: J Physiol Sci. Volume: 63 Pages: 263-270
  • Peer Reviewed
• [Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells (2013)
  • Author(s): Sakurai T, Kitadate K, Nishioka H, Fujii H, Ogasawara J, Kizaki T, Sato S, Fujiwara T, Akagawa K, Izawa T, Ohno H
  • Journal Title: Br J Nutr Volume: 110 Pages: 1549-1558
  • Peer Reviewed
• [Journal Article] The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue. (2013)
  • Author(s): Sakurai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Takahashi M, Kobayashi O, Oh-Ishi S, Nagasawa J, Takahashi K, Ishida H, Izawa T, Ohno H.
  • Journal Title: Int J Endocrinol. Volume: Article ID801743 Pages: 1-28
  • DOI: 10.1155/2013/801743
  • Peer Reviewed
• [Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells. (2013)
  • Author(s): Sakurai T, Kitadate K, Nishioka H, Fujii H, Ogasawara J, Kizaki T, Sato S, Fujiwara T, Akagawa K, Izawa T, Ohno H.
  • Journal Title: Br J Nutr. Volume: 110 Issue: 9 Pages: 1549-1558
  • DOI: 10.1017/s000711451300086x
  • Peer Reviewed
• [Journal Article] 脂肪分解反応を制御する新しいプレーヤーと運動の影響 (2013)
  • Author(s): 井澤鉄也
  • Journal Title: 医学のあゆみ Volume: 244 Pages: 1068-1073
• [Journal Article] Role of nitric oxide in muscle regeneration following eccentric muscle contractions in rat skeletal muscle (2013)
  • Author(s): Tomonobu Sakurai, Osamu Kashimura, Yutaka Kano, Hideki Ohno, Li Li Ji, Tetsuya Izawa, Thomas M. Best
  • Journal Title: J Physiol Sci Volume: 63(4) Issue: 4 Pages: 263-70
  • DOI: 10.1007/s12576-013-0262-y
  • NAID: 10031184279
  • Peer Reviewed
• [Journal Article] Oligonol-induced degradation of perilipin 1 is regulated through lysosomal degradation machinery (2012)
  • Author(s): Ogasawara J, Kitadate K, Nishioka H, Fujii H, Sakurai T, Kizaki T, Izawa T, Ishida H, Ohno H
  • Journal Title: Nat Prod Commun Volume: 7 Pages: 1193-1196
  • Peer Reviewed
• [Journal Article] Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes (2012)
  • Author(s): Ogasawara J, Sakurai T, Kizaki T, Ishibashi Y, Izawa T, Sumitani Y, Ishida H, Radak Z, Haga S, Ohno H
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases (2012)
  • Author(s): Sakurai T, Ogasawara J, Kizaki T, Ishibashi Y, Sumitani Y, Takahashi K, Ishida H, Miyazaki H, Saitoh D, Haga S, Izawa T, Ohno H
  • Journal Title: Environ Health Prev Med Volume: 17 Pages: 348-356
  • Peer Reviewed
• [Journal Article] Effect of physical exercise on lipolysis in white adipocytes (2012)
  • Author(s): Ogasawara J, Sakurai T, Kizaki T, Takahashi K, Ishida H, Izawa T, Toshinai K, Nakano N, Ohno H
  • Journal Title: J Physi Fitness Sports Med Volume: 1 Pages: 351-356
• [Journal Article] Effects of exercise on macrophage functions (2012)
  • Author(s): Kizaki T, Sato S, Sakurai T, Ogasawara J, Imaizumi K, Izawa T, Nagasawa J, Saitoh D, Haga S, Ohno H
  • Journal Title: J Phys Fitness Sports Med Volume: 1 Pages: 113-124
• [Journal Article] Recent advances in the adaptations of adipose tissue to physical activity : morphology and adipose tissue cellularity (2012)
  • Author(s): Izawa T, Ogasawara J, Sakurai T, Nomura S, Kizaki T, Ohno H
  • Journal Title: J Phys Fitness Sports Med Volume: 1 Pages: 381-387
• [Journal Article] Recent advances in the adaptations of adipose tissue to physical activity: Morphology and adipose tissue cellularity (2012)
  • Author(s): 井澤鉄也
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 1 Issue: 3 Pages: 381-387
  • DOI: 10.7600/jpfsm.1.381
  • NAID: 10031158969
  • ISSN: 2186-8123, 2186-8131
  • Peer Reviewed
• [Journal Article] Effect of physical exercise on lipolysis in white adipocytes (2012)
  • Author(s): Ogasawara Junetsu
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 1 Issue: 2 Pages: 351-356
  • DOI: 10.7600/jpfsm.1.351
  • NAID: 10031158965
  • ISSN: 2186-8123, 2186-8131
  • Peer Reviewed
• [Journal Article] Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes. (2012)
  • Author(s): 小笠原準悦
  • Journal Title: PLoS ONE Volume: 7(7) Issue: 7 Pages: e40876-e40876
  • DOI: 10.1371/journal.pone.0040876
  • Peer Reviewed
• [Journal Article] Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training (2011)
  • Author(s): Sakurai T, Ogasawara J, Kizaki T, Ishibashi Y, Fujiwara T, Akagawa K, Izawa T, Oh-ishi S, Haga S, Ohno H
  • Journal Title: Biochem Biophys Res Commun Volume: 416 Pages: 125-129
  • Peer Reviewed
• [Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages (2011)
  • Author(s): Kizaki T, Maegawa T, Sakurai T, Ogasawara JE, Ookawara T, Oh-ishi S, Izawa T, Haga S, Ohno H
  • Journal Title: Biochem Biophys Res Commun Volume: 413 Pages: 454-459
  • Peer Reviewed
• [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes (2011)
  • Author(s): Ogasawara J, Kitadate K, Nishioka H, Fujii H, Sakurai T, Kizaki T, Izawa T, Ishida H, Ohno H
  • Journal Title: Phytother Res Volume: 25 Pages: 467-471
  • Peer Reviewed
• [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats (2011)
  • Author(s): Hatano D, Ogasawara J, Endoh S, Sakurai T, Nomura S, Kizaki T, Ohno H, Komabayashi T, Izawa T.
  • Journal Title: Scand J Med Sci Sports Volume: 21
  • Peer Reviewed
• [Presentation] 持久性走トレーニングによる白色脂肪細胞の脂肪分解反応の亢進にはATGLの発現変化が関与する (2013)
  • Author(s): 小笠原準悦, 櫻井拓也, 佐藤章悟, 石橋義水, 長澤純一, 大石修司, 芳賀脩光, 井澤鉄也, 木崎節子, 大野秀樹
  • Organizer: 第158回日本体力医学会関東地方会
  • Place of Presentation: 東京
• [Presentation] Inhibitory effect of ETAS against amyloid beta-induced cellular disorder in PC12 cells (2013)
  • Author(s): Junetsu Ogasawara,Tomohiro Ito,Jun Takanari, Takuya Sakurai, Shogo Sato, Yoshinaga Ishibashi,Junichi Nagasawa, Daizo Saito, Norihiko Nakano, Tetsuya Izawa, Hideki Ohno
  • Organizer: International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
• [Presentation] 時計遺伝子Rev-erb αはMCP1遺伝子の発現を抑制しマクロファージ免疫機能を制御する (2013)
  • Author(s): 佐藤章悟, 木崎節子, 櫻井拓也, 小笠原準悦, 石橋義永, 長澤純一, 桜井智野風, 井澤鉄也, 今泉和彦, 芳賀脩光, 大野秀樹
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京
• [Presentation] 水泳運動は前駆細胞からの褐色脂肪細胞化を促す (2013)
  • Author(s): 小笠原準悦, 櫻井拓也, 木崎節子, 佐藤章悟, 石橋義水, 井澤鉄也, 宮崎裕美, 斎藤大蔵, 十枝内厚次, 大石修司, 芳賀脩光, 大野秀樹
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京
• [Presentation] 脂肪組織および骨格筋組織における時計遺伝子と脂質代謝関連遺伝子の関連性 (2013)
  • Author(s): 加藤久詞, 増田慎也, 高倉久志, 佐藤章悟,小笠原準悦,櫻井拓也,木崎節子,桜井智野風,大野秀樹,井澤鉄也
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京
• [Presentation] 運動は肥満による脂肪組織のデルマトポンチン発現増加を減弱させる (2013)
  • Author(s): 櫻井拓也, 小笠原準悦, 木崎節子, 石橋義永, 炭谷由計, 井澤鉄也, 石田均, 鈴木健二, 芳賀脩光, 大野秀樹
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学
• [Presentation] Inhibitory effect of ETAS against amyloid beta-induced cellular disorder in PC12 cells. (2013)
  • Author(s): Junetsu Ogasawara,Tomohiro Ito,Jun Takanari, Takuya Sakurai, Shogo Sato, Yoshinaga Ishibashi,Junichi Nagasawa, Daizo Saito, Norihiko Nakano, Tetsuya Izawa, Hideki Ohno.
  • Organizer: 21st International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: 札幌
• [Presentation] 時計遺伝子Rev-erbαはMCP1遺伝子の発現を抑制しマクロファージ免疫機能を制御する (2013)
  • Author(s): 佐藤章悟、木崎節子、櫻井拓也、小笠原準悦、石橋義永、長澤純一、桜井智野風、井澤鉄也、今泉和彦、芳賀脩光、大野秀樹
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京
• [Presentation] アスパラガス茎抽出物は神経細胞の熱ショックタンパク質発現を誘導し,細胞障害を減弱させる (2012)
  • Author(s): 加藤久詞, 増田慎也, 高倉久志, 佐藤章悟,小笠原準悦,櫻井拓也,木崎節子,桜井智野風,大野秀樹,井澤鉄也
  • Organizer: 第20回総合医療機能性食品国際会議
  • Place of Presentation: 札幌
• [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化シグナルを促進する (2012)
  • Author(s): 小笠原準悦, 櫻井拓也, 木崎節子, 佐藤章吾, 井澤鉄也, 芳賀脩光, 今泉和彦, 大石修司, 大野秀樹
  • Organizer: 第67回日本体力医学会
  • Place of Presentation: 岐阜
• [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化シグナルを促進する (2012)
  • Author(s): 小笠原準悦
  • Organizer: 第67回日本体力医学会
  • Place of Presentation: 長良川国際会議場
• [Presentation] アスパラガス茎抽出物は神経細胞の熱ショックタンパク質発現を誘導し，細胞障害を減弱させる (2012)
  • Author(s): 櫻井拓也
  • Organizer: 第20回総合医療機能性食品国際会議
  • Place of Presentation: 札幌市（ロイトン札幌）
• [Presentation] Effects of exercise-training-induced hormonal changes on body composition (2011)
  • Author(s): Izawa T
  • Organizer: The 6th International Conference on Nutrition and Aging
  • Place of Presentation: Tokyo, Japan
• [Presentation] 脂肪細胞の脂肪分解反応に及ぼす新規カテキン型ポリフェノール複合体01igonolの効果 (2011)
  • Author(s): 小笠原準悦, 北舘健太郎, 西岡浩, 藤井創, 櫻井拓也, 木崎節子, 石橋義永, 炭谷由計, 石田 均, 井澤鉄也, 大野秀樹
  • Organizer: 第21回体力・栄養・免疫学会大会
  • Place of Presentation: 北里大学
• [Presentation] 骨格筋から褐色脂肪細胞への分化機構に及ぼす寒冷曝露と水泳運動の効果 (2011)
  • Author(s): 小笠原準悦, 櫻井拓也, 木崎節子, 石橋義永 , 炭谷由計, 井澤鉄也 , 宮崎裕美 , 大石修司 , 芳賀脩光 , 大野秀樹
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 山口
• [Presentation] Effects of exercise-training-induced hormonal changes on body composition. (2011)
  • Author(s): 井澤鉄也
  • Organizer: The 6th International Conference on Nutrition and Aging
  • Place of Presentation: 東京大学
  • Invited
• [Presentation] 骨格筋から褐色脂肪細胞への分化機構に及ぼす寒冷曝露と水泳運動の効果. (2011)
  • Author(s): 小笠原準悦
  • Organizer: 第66回日本体力医学会大会, 山口
  • Place of Presentation: 海峡メッセ下関
• [Presentation] 運動は老化促進モデルマウスの認知機能障害を予防する (2010)
  • Author(s): 櫻井拓也, 小笠原準悦, 木崎節子, 井澤鉄也, 長澤純一, 芳賀脩光, 大野秀樹
  • Organizer: 第18回日本運動生理学会
  • Place of Presentation: 鹿児島大学
• [Presentation] 持久性走トレーニングによる白色脂肪細胞の脂肪分解反応の亢進にはATGLの発現変化が関与する
  • Author(s): 小笠原準悦、櫻井拓也、佐藤章悟、石橋義水、長澤純一、大石修司、芳賀脩光、井澤鉄也、木崎節子、大野秀樹
  • Organizer: 第158回日本体力医学会関東地方会
  • Place of Presentation: 東京
• [Book] ここまでわかった燃える褐色脂肪の不思議 (2013)
  • Author(s): 井澤鉄也
  • Publisher: ナップ
• [Book] ILSI Japan (2012)
  • Author(s): 井澤鉄也
  • Publisher: 運動トレーニングによるホルモン変化とボディコンポジションの変化
• [Book] 脂肪組織のエクササイズバイオロジー (2011)
  • Author(s): 井澤鉄也, 駒林隆夫
  • Publisher: ナップ