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Verification of stress rescue effect of "laughter"

Research Project

Project/Area Number 23300249
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionFoundation for Advancement of International Science

Principal Investigator

MURAKAMI KAZUO  公益財団法人国際科学振興財団, バイオ研究所, 所長 (70110517)

Co-Investigator(Kenkyū-buntansha) HORI Miyo  (財)国際科学振興財団, バイオ研究所, 研究員 (90399329)
SAKAMOTO Shigeko  (財)国際科学振興財団, バイオ研究所, 研究員 (60419869)
OHNISHI Eriko  (公財)国際科学振興財団, バイオ研究所, 研究員 (90396284)
OHNISHI Junji  東京家政大学, 家政学部, 准教授 (40261276)
AYUZAWA Satoshi  筑波技術大学, 保健科学部, 准教授 (20400682)
MATSUSHITA Akira  筑波大学, 最先端サイバニクス研究コア, 研究員 (80532481)
Co-Investigator(Renkei-kenkyūsha) HOSHINO Junichi  筑波大学, 大学院・システム情報工学研究科, 准教授 (40313556)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsストレスマネジメント / 笑い / fMRI / SOC / ストレス / 共感的プロセス尺度 / 1型糖尿病 / 月経随伴症 / functional connectivity / 多元的共感尺度
Research Abstract

The aim of this study was to verify that empathetic laughter may contribute to psychological and somatic health in human via coping with daily stressors. We regarded the emotional reactivity for laughter as a personality trait to empathize with other's positive emotions.On the other hand, sense of coherence (SOC) is dispositional orientation for effective coping and good health. Therefore, we hypothesized that emotional reactivity for laughter may associate with SOC. In this study we found 1) significant negative correlation between SOC score and the psychological and somatic symptoms, 2) the significance of SOC on the positive empathy-derived mood state. To evaluate the stress rescue effect of laughter, we first examine the functional connectivity during watching the laughter-inducing movie by event-related functional MRI. Data analysis showed that movie-induced laughter may associate with discrete regions including orbital part of inferior frontal gyrus.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (31 results)

All 2014 2013 2012 Other

All Journal Article (13 results) (of which Peer Reviewed: 12 results,  Open Access: 1 results) Presentation (17 results) (of which Invited: 4 results) Remarks (1 results)

  • [Journal Article] Tickling during adolescence alters fear-related and cognitive behaviors in rats after prolonged isolation2014

    • Author(s)
      Hori M, Yamada K, Ohnishi J, Sakamoto S, Hiroki Furuie, Murakami K, Ichitani Y
    • Journal Title

      Physiol Behav

      Volume: 131 Pages: 62-7

    • DOI

      10.1016/j.physbeh.2014.04.008

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ticklingは幼若期のラットの情動応答に作用する2014

    • Author(s)
      堀美代
    • Journal Title

      日本生理学雑誌

      Volume: 76巻3号

    • URL

      http://physiology.jp/exec/nisseishi/

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Evaluation of mental stress by physiological indices derived from finger plethysmography2013

    • Author(s)
      Minakuchi E, Ohnishi E, Ohnishi J, Sakamoto S, Hori M, Motomura M, Hoshino J, Murakami K and Kawaguchi T
    • Journal Title

      J Physiol Anthropol

      Volume: 32 Issue: 1 Pages: 17-17

    • DOI

      10.1186/1880-6805-32-17

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of repeated tickling on conditioned fear and hormonal responses in socially isolated rats2013

    • Author(s)
      Hori M, Yamada K, Ohnishi J, Sakamoto S, Takimoto-Ohnishi E, Miyabe S, Murakami K, Ichitani Y
    • Journal Title

      Neurosci Lett

      Volume: 536 Pages: 85-89

    • DOI

      10.1016/j.neulet.2012.12.054

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tickling increases dopamine release in the nucleus accumbens and 50 kHz ultrasonic vocalizations in adolescent rats2013

    • Author(s)
      Hori M, Shimoju R, Tokunaga R, Ohkubo M, Miyabe S, Ohnishi J, Murakami K, Kurosawa M.
    • Journal Title

      Neuroreport

      Volume: 24(5) Issue: 5 Pages: 241-245

    • DOI

      10.1097/wnr.0b013e32835edbfa

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The patient had a normal magnetic resonance imaging and temporal lobe epilepsy secondary to a porencephalic cyst but showed structural lesions (hippocampal sclerosis)2013

    • Author(s)
      Matsubara T, Ayuzawa S, Aoki T, Fujimoto A, Osuka S, Matsumura A
    • Journal Title

      Epilepsy Behav Case Reports

      Volume: 1 Pages: 153-156

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 運動訓練のための実時間脈波検出と装着型提示デバイスへの応用2013

    • Author(s)
      下柿元智也, 鮎澤聡, 鈴木健嗣
    • Journal Title

      情報処理学会論文誌

      Volume: 54(4) Pages: 1480-1488

    • NAID

      110009579563

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 偏光顕微鏡を用いた生体の秩序性の光学的観察2013

    • Author(s)
      鮎澤聡
    • Journal Title

      人体科学

      Volume: 22(1) Pages: 32-35

    • NAID

      110009616500

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat2013

    • Author(s)
      Yamamuro T, Hori M, Nakagawa Y, Hayashi T, Sakamoto S, Ohnishi J, Takeuchi S, Mihara Y, Shiga T, Murakami K, Urayama O
    • Journal Title

      Behav Brain Res

      Volume: 236(1) Issue: 1 Pages: 236-243

    • DOI

      10.1016/j.bbr.2012.09.001

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mind-body medicine : Effect of the mind on gene expression2012

    • Author(s)
      Takimoto-Ohnishi E, Ohnishi J, Murakami K
    • Journal Title

      Person Med Univ

      Volume: 1 Pages: 2-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laughter education for implementation of the smile-sun method to promote natural healing in public and healthcare facilities2012

    • Author(s)
      Takayanagi K, Shimura T, Iwabuchi K, Fujiwara H, Ohnishi J, Ishii K, Murakami K
    • Journal Title

      Jpn Hosp

      Volume: 31 Pages: 57-61

    • URL

      https://www.jstage.jst.go.jp/article/janip/61/2/61_61.2.5/_pdf(

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腹腔鏡支援下の水頭症シャント手術 : 自験例の検討と手技の工夫2012

    • Author(s)
      青木司, 鮎澤聡, 松尾亮太, 細尾久幸, 丹野翔五, 三木俊一郎, 松原鉄平, 松村明
    • Journal Title

      脳神経外科

      Volume: 40(6) Pages: 511-517

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histologically proven venous congestive myelopathy without concurrent vascular malformation : Case reports and review of the literature2012

    • Author(s)
      Matsubara T, Akutsu H, Watanabe S, Nakai K, Ayuzawa S, Matsumura A
    • Journal Title

      Surg Neurol Int

      Volume: 3 Issue: 1 Pages: 87-87

    • DOI

      10.4103/2152-7806.99922

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Tickling alters fear-related and cognitive behaviors in rats isolated during adolescence.2014

    • Author(s)
      Miyo Hori, Kazuo Yamada, Junji Ohnishia, Hiroki Furuie ,Kazuo Murakami, Yukio Ichitani
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington. DC Convention Center(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular insights into mind-body medicine : Effect of "laughter" on gene expression2013

    • Author(s)
      Takimoto-Ohnishi E
    • Organizer
      3rd Annual World ongress of Molecular Medicine-2013
    • Place of Presentation
      Hainan International Convention & Exhibition Center, 中国
    • Year and Date
      2013-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular insights into mind-body medicine : Effect of "laughter" on gene expression2013

    • Author(s)
      Ohnishi J
    • Organizer
      4th World Gene Convention-2013
    • Place of Presentation
      Hainan International Convention & Exhibition Center, 中国
    • Year and Date
      2013-11-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 笑いやすさ」で分かる患者のコヒーレント感覚2013

    • Author(s)
      大西 淳之
    • Organizer
      第12回全国ヤングDMカンファレンス in つくば
    • Place of Presentation
      ノバホール, つくば市
    • Year and Date
      2013-10-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Tickling alters emotional responses in adolescent rats2013

    • Author(s)
      Hori M
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 発芽玄米による授乳婦の疲労改善と関連する遺伝子マーカーの解析2013

    • Author(s)
      坂本成子・大西淳之
    • Organizer
      第60回日本栄養改善学会学術総会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 唾液MHPGの測定によるストレスの客観的評価法の確立2013

    • Author(s)
      貝塚奈緒子・関目綾子・坂本成子・木元幸一・大西淳之
    • Organizer
      第60回日本栄養改善学会学術総会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of tickling on hormonal responses to restraint stress and conditioned fear in socially isolated rats2013

    • Author(s)
      Hori M, Yamada K, Ohnishi J, Sakamoto S, Takimoto-Ohnishi E, Miyabe S, Murakami K, Ichitani Y.et al
    • Organizer
      Society for Neuroscience Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center, 米国
    • Related Report
      2013 Final Research Report
  • [Presentation] 側坐核のドパミンの分泌及ぼすtickling の効果2013

    • Author(s)
      堀美代・山田一夫・大西淳之・村上和雄・一谷幸男
    • Organizer
      第73回日本動物心理学会大会
    • Place of Presentation
      筑波大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 仔ラットの側坐核のドパミンの分泌及ぼすticklingの効果2013

    • Author(s)
      堀美代、下重里江、大西淳之、 村上和雄、黒澤美枝子
    • Organizer
      第73回日本動物心理学会大会
    • Place of Presentation
      筑波大学(茨城県つくば市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of “Laughter” on Gene Expression: Molecular Mechanisms of Positive Emotional Response

    • Author(s)
      大西淳之
    • Organizer
      BIT’s 4th World Gene Convention-2013
    • Place of Presentation
      Hainan International Convention&Exhibition Center(中国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular insights into mind-body medicine: Effect of "laughter" on gene expression.

    • Author(s)
      大西淳之
    • Organizer
      BIT's 3rd Annual World Congress of MolMed-2013
    • Place of Presentation
      Hainan International Convention&Exhibition Center(中国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 「笑いやすさ」で分かる患者のコヒーレント感覚(ストレス対処力)

    • Author(s)
      大西淳之
    • Organizer
      第12回全国ヤングDMカンファレンス in つくば
    • Place of Presentation
      ノバホール(茨城県つくば市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 発芽玄米による授乳婦の疲労改善と関連する遺伝子マーカーの解析

    • Author(s)
      坂本成子、大西淳之
    • Organizer
      第60回日本栄養改善学会学術総会
    • Place of Presentation
      神戸国際展示場 (兵庫県神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 唾液MHPGの測定によるストレスの客観的評価法の確立

    • Author(s)
      貝塚奈緒子、関目綾子、坂本成子、木元幸一、大西淳之
    • Organizer
      第60回日本栄養改善学会学術総会
    • Place of Presentation
      神戸国際展示場 (兵庫県神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of tickling on hormonal responses to restraint stress and conditioned fear in socially isolated rats.

    • Author(s)
      Miyo Hori, Kazuo Yamada, Junji Ohnishia, Kazuo Murakami, Yukio Ichitani
    • Organizer
      Society for Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 隔離飼育ラットにおける快情動刺激(Tickling)の効果

    • Author(s)
      堀美代
    • Organizer
      第45回筑波実験動物研究会講演会
    • Place of Presentation
      文部科学省研究交流センター (茨城県つくば市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://mind-gene.com/

    • Related Report
      2013 Final Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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