Improvement of metabolic and exercise function of skeletal muscles through activation of transcription factor, and prevention of obesity-related liver disease
| Project/Area Number |
23300250
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852)
ISHII Tetsuro 筑波大学, 医学医療系, 教授 (20111370)
UTSUNOMIYA Hirohuto 和歌山県立医科大学, 准教授 (60264876)
GOTO Naohiro 東京海洋大学, 海洋科学部, 准教授 (60323854)
WARABI Eiji 筑波大学, 医学医療系, 講師 (70396612)
OKAMOTO Yoshikazu 筑波大学, 医学医療系, 講師 (90420083)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 肥満関連肝疾患 / 骨格筋 / 転写因子 / 代謝機能 / 運動機能 |
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| Research Abstract |
Each mouse group was subjected to the maximum exercise tolerance test. The results showed that the running distance was significantly shorter in Nrf2KO mice than in wild-type mice. The distance was observed to become longer in the wild-type mice with Nrf2 activation by sulforaphan, a potent Nrf2 activator. The ameliorating effect of exercise on hepatic steatosis of mice fed high sucrose and fat diet was observed in the wild-type mice but not in the Nrf2KO mice. Therefore, we developed cultured myocytes from mouse muscle tissues and investigated the effect of exercise training on myokine production and secretion in the cells. Upon electrical stimulation, Nrf2 was observed to be activated in the myocytes and the production of IL-6, a myokine was markedly increased in the cells. It is likely that Nrf2 expression in myocytes is an important factor influential on exercised-induced myokine production and secretion in the muscles.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] Peroxidoxin I plays a ptotective rrole against UVA irradiation through reduction of oxidative stress2014
Author(s)
Ito T, Kimura S, Seto K, Warabbi E, Kawauchi Y, Shoda J, Tabbuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T
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Journal Title
J Dermatol Sci
Volume: 74
Pages: 9-17
Related Report
Peer Reviewed
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[Journal Article] Expressiion of N-aacetylglucosam minyltransferase V in the subserosal layer correlates wwith postsurggical survivaal of pathological tumor stage 2 carcinoma oof the gallbladder2014
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda, J
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Journal Title
J Gastroenterol
Volume: 49
Pages: 702-714
Related Report
Peer Reviewed
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[Journal Article] Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2013
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Gotoh N, Tokushige K, Hashimoto E, Utsunomiya H, Takahashi H, Ishii T, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 48
Pages: 620-32
NAID
Related Report
Peer Reviewed
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[Journal Article] Glycoproteomics-based cancer marker discovery adopting duall enrichment with Wisteria floribunda agglutinin for high specific glyco-diagnosis of cholangiocarcinoma2013
Author(s)
Matsuda A, Kuno A, Matsuzaki H, Kawamoto T, Shinkai T, Nakanuma Y, Yamamoto M, Ohkohchi N, Ikehara Y, Shoda J, Hirabayashi J, Narimatsu H
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Journal Title
J Proteomics
Volume: 85
Pages: 1-11
Related Report
Peer Reviewed
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[Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain2013
Author(s)
Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, U Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, Sakurai T
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Journal Title
J Neuroscience
Volume: 33
Pages: 14767-14777
Related Report
Peer Reviewed
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2013
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J
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Journal Title
J Gastroenterol
Volume: 49
Pages: 702-714
Related Report
Peer Reviewed
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[Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 47
Pages: 942-35
NAID
Related Report
Peer Reviewed
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[Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J
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Journal Title
J.Gastroenterol
Volume: (印刷中)
Issue: 8
Pages: 924-935
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Deletion of Nrf2leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M,Gotoh N, Tokushige K, Hashimoto E,Utsunomiya H, Takahashi H,Ishii T,Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 48
Issue: 5
Pages: 620-632
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Potent In Vitro and In Vivo Antitumor Activity of Sorafenib Against Human Intrahepatic Cholangio- carcinoma Cells2011
Author(s)
Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, Onodera M, Nakanuma Y, Yamato M, Yamamoto M, Hyodo I, Shoda J
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Journal Title
J Gastroenterol
Volume: 46
Pages: 779-789
NAID
Related Report
Peer Reviewed
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[Presentation] 肝内胆管癌の新規糖蛋白質マーカーの開発2013
Author(s)
小貫建一郎, 樋口亮太, 谷澤武久, 梶山英樹, 川本徹, 山本雅一, 中沼安二, 大河内信弘, 松田厚志, 久野 敦, 成松 久, 正田純一
Organizer
第49回胆道学会
Place of Presentation
千葉
Related Report
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