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Prevention and improvement of sarcopenia by means of skeletal muscle electrical stimulation

Research Project

Project/Area Number 23300253
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionKyoto University

Principal Investigator

MORITANI Toshio  京都大学, 人間・環境学研究科(研究院), 教授 (90175638)

Co-Investigator(Kenkyū-buntansha) HAYASHI Tatsuya  京都大学, 大学院・人間・環境学研究科, 教授 (00314211)
SAKANE Naoki  京都医療センター, 室長 (40335443)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords筋電気刺激 / 加齢性筋肉減少症 / 運動療法 / 高齢者 / 骨格筋電気刺激 / サルコペニア / 筋肥大 / エネルギー代謝 / 脳由来神経栄養因子
Research Abstract

The purpose of this study was to investigate the effects of skeletal muscle electrical stimulation upon prevention and improvement of sarcopenia in the elderly. Forty-one elderly persons were divided into three groups (Control, Electrical stimulation Group, Electrical Stimulation with nutritional supplement Group) in order to determine the effects of functional electrical muscle stimulation upon care-prevention and QOL of the elderly. Results indicated that electrical muscle stimulation together with nutritional intervention group demonstrated significant increases in muscle cross sectional area and knee extension strength. In addition, 23 elderly persons who received electrical muscle stimulation demonstrated a significantly lower decline in the age-associated decrease in brain derived neurotrophic factor (BDNF) level.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (40 results)

All 2014 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (29 results) (of which Invited: 10 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Metabolic cardiovascular responses during voluntary pedaling exercise with electrical stimulation2014

    • Author(s)
      Watanabe K, Taniguchi Y, Moritani T
    • Journal Title

      European Journal of Applied Physiology

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 経皮的電気刺激(B-SES)2014

    • Author(s)
      森谷敏夫
    • Journal Title

      整形外科

      Volume: (印刷中)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Motor unit firing pattern of vastus lateralis muscle in type 2 diabetes mellitus patients.2013

    • Author(s)
      Watanabe K, Gazzoni M, Holobar A, Miyamoto T, Fukuda K, Merletti R, Moritani T.
    • Journal Title

      Muscle & Nerve

      Volume: 48(5): Issue: 5 Pages: 806-813

    • DOI

      10.1002/mus.23828

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Region-specific myoelectric manifestations of fatigue in human rectus femoris muscle.2013

    • Author(s)
      Watanabe K, Kouzaki M, Moritani T.
    • Journal Title

      Muscle & Nerve

      Volume: 48 (2) Issue: 2 Pages: 226-234

    • DOI

      10.1002/mus.23739

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subthreshold electrical stimulation reduces motor unit discharge variability and decreases the force fluctuations of plantar flexion2012

    • Author(s)
      Kouzaki M, Kimura T, Yoshitake Y, Hayashi T, Moritani T
    • Journal Title

      Neuroscience Letters

      Volume: 513 Pages: 146-150

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effect of percutaneous Electrical Muscle Stimulation on postprandial hyperglycemia in type 2 diabetes2012

    • Author(s)
      Miyamoto T, Fukuda K, Kimura T, Matsubara Y, Tsuda K, Moritani T
    • Journal Title

      Dibetes Res Clin Pract

      Volume: 96 Pages: 306-312

    • Related Report
      2013 Final Research Report
  • [Journal Article] Spatial EMG potential distribution pattern of vastus lateralis muscle during isometric knee extension in young and elderly men2012

    • Author(s)
      Dibetes Res Clin Pract
    • Journal Title

      Journal of Electromyography and Kinesiology

      Volume: 22 Pages: 74-79

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effect of percutaneous Electrical Muscle Stimulation on postprandial hyperglycemia in type 2 diabetes.2012

    • Author(s)
      Miyamoto, T. et al.
    • Journal Title

      Dibetes Research and Clinical Practice

      Volume: 96 Issue: 3 Pages: 306-312

    • DOI

      10.1016/j.diabres.2012.01.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of early implementation of electrical muscle stimulation to prevent muscle atrophy and weakness in patients after anterior cruciate ligament reconstruction2011

    • Author(s)
      Hasegawa S, Kobayashi M, Arai R, Tamaki A, Nakamura T, Moritani T
    • Journal Title

      Journal of Electromyography and Kinesiology

      Volume: 21 Pages: 622-630

    • NAID

      120003238939

    • Related Report
      2013 Final Research Report
  • [Presentation] 骨格筋電気刺激の臨床応用2013

    • Author(s)
      森谷敏夫
    • Organizer
      広島リハビリテーション研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] サルコペニアにおける栄養と運動の役割2013

    • Author(s)
      森谷敏夫
    • Organizer
      第67回日本栄養・食糧学会 ネスレ栄養科学会議サテライトシンポジウム「栄養と加齢の生物学」
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 生涯現役のための運動と栄養2013

    • Author(s)
      森谷敏夫
    • Organizer
      オールジャパン「食と健康」シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 骨格筋電気刺激によるβエンドルフィンの変化2013

    • Author(s)
      森谷敏夫
    • Organizer
      第14回日本電気生理運動学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 電気刺激による代謝調節と臨床応用2013

    • Author(s)
      森谷敏夫
    • Organizer
      関東運動器リハ研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] サルコペニアにおける栄養と運動の役割」2013

    • Author(s)
      森谷敏夫
    • Organizer
      第67回日本栄養・食糧学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「電気刺激による代謝調節と臨床応用」2013

    • Author(s)
      森谷敏夫
    • Organizer
      関東運動器リハ研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Anti-obesity and psychotropic effects on electrical muscle stimulation in Schizophrenia2012

    • Author(s)
      Fujibayashi M, Kishida I, Ishii C, Norio Ishii, Moritani T
    • Organizer
      Asian College of Psychosomatic Medicine Congress 2012
    • Place of Presentation
      Ulaanbaatar, Mongolia
    • Related Report
      2013 Final Research Report
  • [Presentation] Gender differences in metabolic responses to Electrical muscle stimulation in type 2 diabetes2012

    • Author(s)
      Miyamoto T, Fukuda K, Watanabe K, Moritani T
    • Organizer
      19th Congress of the International Society of Electrophysiology and Kinesiology
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] New Frontiers in Electrical Muscle Stimulation : Is it an effective treatment for the major lifestyle related diseases of modern society?. Keynote Lecture2012

    • Author(s)
      Moritani T
    • Organizer
      19th Congress of the International Society of Electrophysiology and Kinesiology
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] Muscle Training for Prevention and Improvement of Lifestyle-related Diseases and Brain Function. Keynote Lecture2012

    • Author(s)
      Moritani T
    • Organizer
      35th National Strength and Conditioning Association Annual Meeting
    • Place of Presentation
      Rhode Island, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] The Role of Exercise and Nutrition in Lifestyle-related Disease. Keynote Lecture2012

    • Author(s)
      Moritani T
    • Organizer
      The 6th International Sport Sciences Symposium on "Active Life"
    • Place of Presentation
      Tokorozawa
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動療法の意義と実践2012

    • Author(s)
      森谷敏夫
    • Organizer
      沖縄関節外科研究会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動科学から見たリハビリテーションの未来と可能性2012

    • Author(s)
      森谷敏夫
    • Organizer
      第22回京都府理学療法士会
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢者における筋力トレーニングの意義と実践2012

    • Author(s)
      森谷敏夫
    • Organizer
      食と生命のサイエンス・フォーラム
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 高齢者の筋力トレーニングの意義と実践2012

    • Author(s)
      森谷敏夫
    • Organizer
      第12回日本抗加齢医学会総会
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 電気刺激による代謝調節と臨床応用2012

    • Author(s)
      森谷敏夫
    • Organizer
      第19回日本FES研究会学術講演会
    • Related Report
      2013 Final Research Report
  • [Presentation] サルコペニアにおける運動と栄養の役割2012

    • Author(s)
      森谷敏夫
    • Organizer
      第2回日本リハビリテーション栄養研究会
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] New Frontiers in Electrical Muscle Stimulation: Is it an effective treatment for the major lifestyle related diseases of modern society?.2012

    • Author(s)
      Moritani, T.
    • Organizer
      19th Congress of the International Society of Electrophysiology and Kinesiology
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Muscle Training for Prevention and Improvement of Lifestyle-related Diseases and Brain Function.2012

    • Author(s)
      Moritani, T.
    • Organizer
      35th National Strength and Conditioning Association Annual Meeting
    • Place of Presentation
      Rhode Island, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ヒト大腿直筋における部位依存的な機能的役割の違い2011

    • Author(s)
      渡邊航平, 神崎素樹, 森谷敏夫
    • Organizer
      第25回身体動作学研究会
    • Place of Presentation
      日本体育大学
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生活習慣病に対する運動の予防医学的効果2011

    • Author(s)
      森谷敏夫
    • Organizer
      第62回日本栄養・食糧学会中部支部大会
    • Place of Presentation
      岐阜大学(招待講演)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症患者における骨格筋電気刺激が体組成および精神症状に及ぼす影響2011

    • Author(s)
      藤林真美, 石井千恵, 森谷敏夫
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心臓リハビリへの筋電気刺激療法の臨床応用2011

    • Author(s)
      森谷敏夫
    • Organizer
      ベルン病心臓リハビリテーション会議
    • Place of Presentation
      スイスベルン病院(招待講演)
    • Year and Date
      2011-07-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 運動療法の意義と実践2011

    • Author(s)
      森谷敏夫
    • Organizer
      第121回西日本整形・災害外科学会学術集会
    • Place of Presentation
      九州大学医学部百年講堂(招待講演)
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症患者における骨格筋電気刺激が体組成および精神症状に及ぼす影響2011

    • Author(s)
      藤林真美, 石井千恵, 岸田郁子, 石井紀夫, 森谷敏夫
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      山口
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢者における認知機能と身体活動レベル2011

    • Author(s)
      藤林真美, 渡邊航平, 石井千恵, 森谷敏夫
    • Organizer
      日本体育学会第62回大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 基調講演「健康長寿のためのおもしろ健康科学」文部科学省イノベーションシステム整備事業2011

    • Author(s)
      森谷敏夫
    • Organizer
      平成23年度キックオフフォーラム
    • Place of Presentation
      奈良
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動療法の意義と実践2011

    • Author(s)
      森谷敏夫
    • Organizer
      第121回西日本整形・災害外科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] Use of whey protein in combination with electrical muscle stimulation2013

    • Inventor(s)
      森谷敏夫
    • Industrial Property Rights Holder
      Nestec S.A.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-04-13
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 電気刺激用装着具2012

    • Inventor(s)
      森谷敏夫, ホーマーイオン研究所
    • Industrial Property Rights Holder
      森谷敏夫, ホーマーイオン研究所
    • Filing Date
      2012-06-14
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-04-06   Modified: 2019-07-29  

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