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Disorder of cell adhesion system in tumor progression

Research Project

Project/Area Number 23300351
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor biology
Research InstitutionYokohama City University

Principal Investigator

MIYAZAKI KAORU  横浜市立大学, 付置研究所, その他 (70112068)

Co-Investigator(Renkei-kenkyūsha) HIGASHI Shouichi  横浜市立大学, 大学院・生命ナノシステム科学研究科, 准教授 (10275076)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywordsがん浸潤 / 細胞接着分子 / ラミニン332 / ラミニンγ2 / 上皮間葉変換(EMT) / CD44 / がん幹細胞 / 腫瘍血管 / 腫瘍-間質相互作用 / がん浸潤モデル / コラーゲンゲル / HGF / TGF-beta / ラミニン / 線維芽細胞 / EMT / TGF-β / 細胞接着 / 浮遊性増殖 / 浸潤モデル / 微小管 / コラーゲンマトリックス / がんの浸潤 / 浮遊増殖 / 腹水
Research Abstract

Non-invasive tumor cells are fixed on basement membranes (BMs) by stably binding to cell adhesion proteins such as laminin-332 (Lm332). However, they start to invade the BMs and then stroma during tumor progression. In this study, we investigated the mechanism of tumor invasion, mainly focusing on the interaction of tumor cells with cell adhesion proteins. Major results are as follows.
Laminin gamma2 (Lm-g2), a subunit of Lm332, is often overexpressed in invasive human cancers and hence regarded as a tumor invasion marker. We found that (1) Lm-g2 is induced in association with epithelial-mesenchymal transition of tumor cells, and (2) amino-terminal fragments of Lm-g2 directly interacts with the cancer stem cell marker CD44 in metastatic cancer cells, leading to the stimulation of their migration. These results suggest the cooperation of the two important tumor markers for cancer progression. We also found that Lm-g2 acts on vascular endothelial cells, increasing vascular permeability.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (67 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 13 results,  Open Access: 3 results) Presentation (45 results) (of which Invited: 1 results) Book (4 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Amino-terminal fragments of laminin gamma2 chain retract vascular endothelial cells and increase vascular permeability.2014

    • Author(s)
      Sato, H, Oyanagi, J., Komiya, E., Ogawa, T, Higashi, S., Miyazaki, K.
    • Journal Title

      Cancer Sci.

      Volume: 105 Issue: 2 Pages: 168-175

    • DOI

      10.1111/cas.12323

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5).2014

    • Author(s)
      Kamoshida, G., Ogawa, T., Oyanagi, J., Sato, H., Komiya, E., Higashi, S., Miyazaki, K., Tsuji, T.
    • Journal Title

      Clin. Exp. Metastasis

      Volume: 31 Issue: 3 Pages: 285-291

    • DOI

      10.1007/s10585-013-9627-0

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiomodulin (AGM/IGFBP-rP1) is a molecular marker of vascular endothelial cells activated by VEGF in human breast cancers.2014

    • Author(s)
      Komiya, E, Sato, H., Ise, I., Watanabe, N., Higashi, H., Miyagi, Y., Miyazaki, K.
    • Journal Title

      Cancer Med

      Volume: 印刷中 Issue: 3 Pages: 537-549

    • DOI

      10.1002/cam4.216

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor.2014

    • Author(s)
      Oyanagi, J., Kojima, N., Sato, H., Higashi, S., Kikuchi, K., Sakai, K., Matsumoto, K., Miyazaki, K.
    • Journal Title

      Exp Cell Res.

      Volume: 印刷中 Issue: 2 Pages: 267-279

    • DOI

      10.1016/j.yexcr.2014.04.009

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2)2013

    • Author(s)
      Higashi, S., Hirose, T., Takeuchi, T., Miyazaki, K.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 13 Pages: 9066-9076

    • DOI

      10.1074/jbc.m112.441758

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated expression of angiomodulin (AGM/GFBP-rP1) in tumor stroma and its roles in fibroblast activation2012

    • Author(s)
      Eriko Komiya
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 4 Pages: 691-699

    • DOI

      10.1111/j.1349-7006.2012.02203.x

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymerized Laminin-332 Matrix Supports Rapid and Tight Adhesion of Keratinocytes, Suppressing Cell Migration2012

    • Author(s)
      Kariya, Y., Miyazaki, K., al
    • Journal Title

      PLoSONE

      Volume: 7 Issue: 5 Pages: 95-107

    • DOI

      10.1371/journal.pone.0035546

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-Bound and Exosomal Metastasis-Associated C4.4A Promotes Migration by Associating with the α_6β_4 Integrin and MT1-MMP2012

    • Author(s)
      Ngora, H., Miyazaki, K., et al
    • Journal Title

      Neoplasia

      Volume: 14 Issue: 2 Pages: 95-107

    • DOI

      10.1593/neo.111450

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial-mesenchymal transition stimulates human cancer cells to extend microtubule-based invasive protrusions and suppresses cell growth in collagen gel2012

    • Author(s)
      Oyanagi, J., Ogawa, T., Sato, H., Higashi, S., Miyazaki, K
    • Journal Title

      PLoS ONE

      Volume: 7(12)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial-mesenchymal transition stimulates human cancer cells to extend microtubule-based invasive protrusions and suppresses cell growth in collagen gel.2012

    • Author(s)
      Oyanagi, J.
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: 1-13

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers2011

    • Author(s)
      Mori, T., Miyazaki, K., et al
    • Journal Title

      Cancer Sci.

      Volume: 102 Issue: 5 Pages: 1095-1100

    • DOI

      10.1111/j.1349-7006.2011.01892.x

    • NAID

      10029293987

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of beta-amyloid precursor protein-derived inhibitor2011

    • Author(s)
      Hashimoto, H., Takeuchi, T., Komatsu, K., Miyazaki, K., Sato, M., Higashi, S
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 33236-33243

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of beta-amyloid precursor protein-derived inhibitor.2011

    • Author(s)
      Hashimoto, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 206 Pages: 33236-33243

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pericellular proteolysis by matrix metallo proteinase-7 is differentially modulated by cholesterol sulfate, sulfatide and cardiolipin

    • Author(s)
      Yamamoto, K., Miyazaki, K., Higashi, S
    • Journal Title

      FEBS J

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 基底膜分子ラドシン/ラミニン5/ラミニン332の構造と機能2013

    • Author(s)
      宮崎香
    • Organizer
      水疱症研究会
    • Place of Presentation
      大分, 藤原作平会頭
    • Year and Date
      2013-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Angiomodulin (AGM/IGFBP-rP1) is overexpressed in tumor vasculature and regulates adhesion of vascular endothelial cells via integrin αvβ3 : Possible roles in tumor angiogenesis2013

    • Author(s)
      Kaoru Miyazaki, Eriko Komiya, Hiroki Sato, Yohei Miyagi, Shouichi Higashi
    • Organizer
      AACR Conference "Tumor Invasion and Metastasis"
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Laminin gannma2 Chain Induces Vascular Hyperpermeability through Its Heparin-Binding Site of N-terminal EGF-like Repeat2013

    • Author(s)
      Hiroki Sato, Shouichi Higashi and Kaoru Miyazaki
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] A synthetic inhibitor of TGF- stimulates tumor cell invasion by enhancing secretion of HGF from fibroblasts in vitro2013

    • Author(s)
      Jun Oyanagi, Shouichi Higashi, Keiji Kikuchi, Katsuya Sakai, Kunio Matusmoto, Kaoru Miyazaki
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Angiomodulin, a cancer blood vessel marker induced by VEGF, enhances vascular permeability through integrin alpha-v/beta-32013

    • Author(s)
      Eriko Komiya, Hiroki Sato, Shouich Higashi, Yohei Miyagi, Kaoru Miyazaki
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] ラミニンγ2鎖N末端領域に存在するヘパリン結合部位の血管透過性亢進活性2013

    • Author(s)
      佐藤拓輝, 宮崎香
    • Organizer
      第22回日本がん転移学会学術集会・総会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞外マトリックスタンパク質ラミニン-332 による単球の分化とマトリックスメタロプロテイナーゼ-9 産生調節2013

    • Author(s)
      鴨志田 剛, 佐藤 拓輝, 宮崎 香, 辻 勉
    • Organizer
      第22回日本がん転移学会学術集会・総会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] 基底膜分子ラドシン/ラミニン5/ラミニン332の構造と機能。2013

    • Author(s)
      宮崎香
    • Organizer
      水疱症研究会特別講演
    • Place of Presentation
      大分
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Laminin gannma2 Chain Induces Vascular Hyperpermeability through Its Heparin-Binding Site of N-terminal EGF-like Repeat.2013

    • Author(s)
      Hiroki Sato, Shouichi Higashi and Kaoru Miyazaki
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] A synthetic inhibitor of TGF- stimulates tumor cell invasion by enhancing secretion of HGF from fibroblasts in vitro.2013

    • Author(s)
      Jun Oyanagi1, Shouichi Higashi, Keiji Kikuchi, Katsuya Sakai, Kunio Matsumoto, and Kaoru Miyazaki
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Angiomodulin, a cancer blood vessel marker induced by VEGF, enhances vascular permeability through integrin alpha-v/beta-3.2013

    • Author(s)
      Eriko Komiya, Hiroki Sato, Shouich Higashi, Yohei Miyagi, Kaoru Miyazaki
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラミニンγ2鎖N末端領域に存在するヘパリン結合部位の血管透過性亢進活性。2013

    • Author(s)
      佐藤拓輝、宮崎香
    • Organizer
      第22回日本がん転移学会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞外マトリックスタンパク質ラミニン-332 による単球の分化とマトリックスメタロプロテイナーゼ-9 産生調節。2013

    • Author(s)
      鴨志田剛 ,佐藤拓輝,宮崎香, 辻勉
    • Organizer
      第22回日本がん転移学会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Angiomodulin (AGM/IGFBP-rP1) is overexpressed in tumor vasculature and regulates adhesion of vascular endothelial cells via integrinαvβ3: Possible roles in tumor angiogenesis.2013

    • Author(s)
      Kaoru Miyazaki
    • Organizer
      AACR Conference
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Overxpression of Angiomodulin (AGM/IGFBPrP1) in Tumor Stroma and Vasculature : Differential Regulation and Functions2012

    • Author(s)
      Eriko komiya, Hiroki Sato, Yohei Miyagi, Shouichi Higashi, Kaoru Miyazaki
    • Organizer
      The 14th International Biennial Congress of the Metastasis Research Association
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] Laminin γ2 chain Promotes Invasion of Tumor Cells into Vascular Endothelial Cell Layer In Vitro2012

    • Author(s)
      Hiroki Sato, Takashi Ogawa, Eriko Komiya, Jun Oyanagi, Shouichi Higashi, Kaoru Miyazaki
    • Organizer
      The 14th International Biennial Congress of the Metastasis Research Association
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] Overxpression of Angiomodulin (AGM/IGFBPrP1) in Tumor Stroma and Vasculature : Differential Regulation and Functions2012

    • Author(s)
      Eriko Komiya, Hiroki Sato, Shouich Higashi, Yohei Miyagi, Kaoru Miyazaki
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] EMT of tumor cells promotes microtubule-based protrusions in 3D collagen matrix, suppressing cell growth2012

    • Author(s)
      Jun Oyanagi, Hiroki Sato, Shouichi Higashi, Kaoru Miyazaki
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Laminin γ2 Chain Induces Transendothelial Migration of Cancer Cells by Modulating Cytoskeleton of Endothelial Cells2012

    • Author(s)
      Hiroki Sato, Jun Oyanagi, Eriko Komiya, Shouichi Higashi, Kaoru Miyazaki
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Overexpression of Angiomodulin (AGM/IGFBP-rP1) in Tumor Stroma and Vasculature:Differential Regulation and Functions.2012

    • Author(s)
      Eriko Komiya
    • Organizer
      The 14th International Biennial Congress of the Metastasis Research Association
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Laminin γ2 chain Promotes Invasion of Tumor Cells into Vascular Endothelial Cell Layer In Vitro.2012

    • Author(s)
      Hiroki Sato
    • Organizer
      The 14th International Biennial Congress of the Metastasis Research Association.
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Overexpression of Angiomodulin (AGM/IGFBP-rP1) in Tumor Stroma and Vasculature: Differential Regulation and Functions.2012

    • Author(s)
      Eriko Komiya
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] EMT of tumor cells promotes microtubule-based protrusions in 3D collagen matrix, suppressing cell growth.2012

    • Author(s)
      Jun Oyanagi
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Laminin γ2 Chain Induces Transendothelial Migration of Cancer Cells by Modulating Cytoskeleton of Endothelial Cells.2012

    • Author(s)
      Hiroki Sato
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Epithelial-mesenchymal transition (EMT) stimulates tumor cells to produce invadopodia-like protrusions in collagen matrix, suppressing cell growth2011

    • Author(s)
      Jun Oyanagi, Shouichi Higashi, Kaoru Miyazaki
    • Organizer
      American Association for Cancer Research 102nd Annual Meeting Innovation and Collaboration to Progress
    • Place of Presentation
      Florida in U.S.A
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトがん細胞における細胞接着能消失メカニズムの解析2011

    • Author(s)
      関根玲子, 佐藤拓輝, 宮崎香
    • Organizer
      第84回生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] ヒト間葉系幹細胞の増殖と分化に及ぼす各種ラミニン分子の作用2011

    • Author(s)
      藤田幸, 柳川聡秀, 今林司, 高橋瑛美, 小柳潤, 宮崎香
    • Organizer
      第84回生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] APP 由来インヒビターペプチドによる MMP-2 選択的阻害機構の解明2011

    • Author(s)
      竹内友香, 橋本博, 宮崎香, 佐藤衛, 東昌市
    • Organizer
      第84回生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Epithelial-mesenchymal transition promotes invadopodia-like protrusions in collagen gel., suppressing cell growth2011

    • Author(s)
      Jun oyanagi, Hiroki Sato, Shouichi Higashi, Kaoru Miyazaki
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] TRPM5 is a transducer of extrscellular acidic pH in melanoma cells and contributes lung metastasis2011

    • Author(s)
      Yasumasa Kato, Ryuichiro Hata, Mamoru Tsukuda, Kaoru Miyazaki, Yoji Nagashima
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Tumor-derived adhesion factor IGFBP-rP1/TAF promotes growth of human fibroblasta and their fibronectin expression2011

    • Author(s)
      Eriko Komiya, Kaoru Miyazaki, Shouichi Higashi
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Laminin γ2 chain Promotes Invasion of Tumor Cells into Vascular Endothelial Cell Layer In Vitro2011

    • Author(s)
      Hiroki Sato, Jun Oyanagi, Shouichi Higashi, Kaoru Miyazaki
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管基底膜に存在する新規ラミニン分子ラミニン 3B11 の発現と性質2011

    • Author(s)
      宮崎香
    • Organizer
      第43回日本結合組織学会
    • Place of Presentation
      別府
    • Related Report
      2013 Final Research Report
  • [Presentation] がん浸潤マーカー・ラミニンγ2 鎖の血管内皮浸潤促進活性とその機構2011

    • Author(s)
      佐藤拓輝, 宮崎香
    • Organizer
      第20回日本がん転移学会学術集会・総会
    • Place of Presentation
      浜松
    • Related Report
      2013 Final Research Report
  • [Presentation] Biomarkers in keratinocyte senescence and skin elasticity2011

    • Author(s)
      Chie Yasuda, Nakaba Kayanuma, Minako Takahashi, Shioji Ishiwatari, Kaoru Miyazaki, Shoko Matsukuma
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Epithelial-mesenchymal transition (EMT) stimulates tumor cells to produce invadopodia-like protrusions in collagen matrix, suppressing cell growth.2011

    • Author(s)
      Jun Oyanagi
    • Organizer
      American Association for Cancer Research 102nd Annual Meeting Innovation and Collaboration to Progress
    • Place of Presentation
      Florida in U.S.A.
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト間葉景観細胞の増殖と文化に及ぼす各種ラミニン分子の作用2011

    • Author(s)
      藤田幸
    • Organizer
      第84回生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] APP由来インヒビターペプチドによるMMP-2選択的阻害機構の解明2011

    • Author(s)
      竹内友香
    • Organizer
      第84回生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epithelial-mesenchymal transition promotes invadopodia-like protrusions in collagen gel, suppressing cell growth.2011

    • Author(s)
      Jun Oyanagi
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRPM5 is a transducer of extrscellular acidic pH in melanoma cells and contributes lung metastasis.2011

    • Author(s)
      Yasumasa Kato
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tumor-derived adhesion factor IGFBP-rP1/TAF promotes growth of human fibroblasta and their fibronectin expression.2011

    • Author(s)
      Eriko Komiya
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Laminin γ2 chain Promotes Invasion of Tumor Cells into Vascular Endothelial Cell Layer In Vitro.2011

    • Author(s)
      Hiroki Sato
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管基底膜に存在する新規ラミニン分子ラミニン3B11の発現と性質2011

    • Author(s)
      宮崎香
    • Organizer
      日本結合組織学会会
    • Place of Presentation
      大分県別府
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん浸潤マーカー・ラミニンγ2鎖の血管内皮浸潤促進活性とその機構2011

    • Author(s)
      佐藤拓輝
    • Organizer
      第20回日本がん転移学会学術集会・総会
    • Place of Presentation
      静岡県浜松
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biomarkers in keratinocyte senescence and skin elasticity.2011

    • Author(s)
      Chie Yasuda
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Annual Research Report
  • [Book] 「タンパク質実験ノート改訂第 4 版」(上巻)2011

    • Author(s)
      岡田雅人, 宮崎香 編著
    • Total Pages
      215
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] 「タンパク質実験ノート改訂第 4 版」(下巻)2011

    • Author(s)
      岡田雅人, 三木裕明, 宮崎香 編著
    • Total Pages
      222
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] 「タンパク質実験ノート改訂第4版」(上巻)2011

    • Author(s)
      岡田雅人
    • Total Pages
      215
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] 「タンパク質実験ノート改訂第4版」(下巻)2011

    • Author(s)
      岡田雅人
    • Total Pages
      222
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] ラミニン 5 を利用した間葉系幹細胞の培養技術2012

    • Inventor(s)
      宮崎香, 橋本じゅん子, 苅谷慶喜
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-05-25
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] ラミニン 6B(ラミニン 3B11)蛋白質2012

    • Inventor(s)
      宮崎香
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-11-30
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] ラミニン 5B2011

    • Inventor(s)
      宮崎香, 苅谷慶喜
    • Industrial Property Rights Holder
      横浜 TLO
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2011-08-12
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] Skin aging marker and technique for use thereof. US 特許認定2011

    • Inventor(s)
      Satoshi Miyata, Kaoru Miyazaki, Chie Yasuda, Akihiro Iwamatsu
    • Industrial Property Rights Holder
      株式会社ファンケル
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2011-07-05
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-04-06   Modified: 2019-07-29  

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