Analysis of suppressive mechanisms by regulatory T cells

• Project/Area Number: 23300354
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor immunology
• Research Institution: Osaka University
• Principal Investigator: NISHIKAWA Hiroyoshi 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (10444431)
• Co-Investigator(Renkei-kenkyūsha): DOKI Yuichiro 大阪大学, 大学院・医学系研究科, 教授 (20291445) ; TANEMURA Atsushi 大阪大学, 大学院・医学系研究科, 助教 (50457016)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000); Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: 癌 / 制御性T細胞 / 抗腫瘍免疫応答 / CD4+制御性T細胞 / エフェクターT細胞

Research Abstract

The phenotypes and characteristics of regulatory T (Treg) cells in tumors were investigated. Treg cells infiltrating into tumors exhibited effector Treg-cell phenotypes and highly expressed CC chemokine receptor 4 (CCR4). Selective depletion of effector-type Tregs by targeting CCR4 induced/augmented cancer antigen-specific CD4+ and CD8+ T-cell responses. In addition, analysis of CD8+ T cells suppressed by Treg cells an unveiled hitherto undefined T-cell phenotype, suggesting a novel mechanism of Treg-cell suppression.

Research Products

• [Journal Article] Regulatory T cells in cancer immunotherapy. (2014)
  • Author(s): Nishikawa H, Sakaguchi S
  • Journal Title: Current Opinion Immunology Volume: 27 Pages: 1-7
  • DOI: 10.1016/j.coi.2013.12.005
  • NAID: 130004696113
  • Peer Reviewed
• [Journal Article] Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. (2014)
  • Author(s): Wada H, Isobe M, Kakimi K, Mizote Y, Eikawa S, Sato E, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Yamasaki M, Miyata H, Matsushita H, Udono H, Seto Y, Yamada K, Nishikawa H, Pan L, Venhaus R, Oka M, Doki Y, Nakayama E.
  • Journal Title: J. Immunother. Volume: 37(2) Pages: 84-92
  • DOI: 10.1097/cji.0000000000000017
  • Peer Reviewed
• [Journal Article] Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking anti-tumor immune responses in humans. (2013)
  • Author(s): Sugiyama D, Nishikawa H, Maeda Y, Nishioka M, Tanemura A, Katayama I, Ezoe S, Kanakura Y, Sato E, Fukumori Y, Karbach J, Jager E and Shakaguchi S
  • Journal Title: Proceedings of National Academy of Science USA Volume: 110(44) Pages: 17945-17950
  • DOI: 10.1073/pnas.1316796110
  • Peer Reviewed
• [Journal Article] Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.? ?? (2013)
  • Author(s): Koji Atarashi, Takeshi Tanoue, et al.
  • Journal Title: Nature Volume: 500 Pages: 232-236
  • DOI: 10.1038/nature12331
  • Peer Reviewed
• [Journal Article] Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes. (2013)
  • Author(s): Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old LJ, Gnjatic S, and Shiku H
  • Journal Title: Eur J Immunol. Volume: 43 (4) Pages: 989-1000
  • DOI: 10.1002/eji.201242800
  • Peer Reviewed
• [Journal Article] Natural and induced T regulatory cells in cancer. (2013)
  • Author(s): Dennis Adeegbe and Hiroyoshi Nishikawa
  • Journal Title: Frontiers in Immunology Volume: 4 Pages: 190-190
  • DOI: 10.3389/fimmu.2013.00190
  • Peer Reviewed
• [Journal Article] Antibody-based therapy in colorectal cancer. (2013)
  • Author(s): Noguchi T, Ritter G, Nishikawa H
  • Journal Title: Immunotherapy Volume: 5(5) Pages: 533-545
  • DOI: 10.2217/imt.13.35
  • Peer Reviewed
• [Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8(+) T cells (2013)
  • Author(s): Muraoka D, Nishikawa H, Noguchi T, Wang L, Harada N, Sato E, Luescher I, Nakayama E, Kato T, Shiku H
  • Journal Title: Vaccine Volume: 31(17) Pages: 2110-2118
  • DOI: 10.1016/j.vaccine.2013.02.056
  • Peer Reviewed
• [Journal Article] NY-ESO-1 antibody as a novel tumour marker of gastric cancer (2013)
  • Author(s): Fujiwara S, Wada H, Kawada J, Kawabata R, Takahashi T, Fujita J, Hirao T, Shibata K, Makari Y, Iijima S, Nishikawa H, Jungbluth AA, Nakamura Y, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Nakayama E, Mori M, Doki Y.
  • Journal Title: British Journal of Cancer Volume: 108(5) Pages: 1119-1125
  • DOI: 10.1038/bjc.2013.51
  • Peer Reviewed
• [Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: potential utility for adoptive immunotherapy. (2013)
  • Author(s): Liu B, Ohishi K, Orito Y,N a k a mo r i Y, Nishikawa H, Ino K,Suzuki K, Matsumoto T,Masuya M,Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N.
  • Journal Title: Exp Hematol. Volume: - Pages: 367-376
  • DOI: 10.1016/j.exphem.2012.12.001
  • Peer Reviewed
• [Journal Article] Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-191-110) peptide (2013)
  • Author(s): Eikawa, S., Kakimi, K., Idobe, M., Kuzushima, K., Luescher, I., Ohue, Y., Ikeuchi, K., Uenaka, A., Nishikawa, H., Udono, H., Oka, M., and Nakayama, E.
  • Journal Title: International Journal of Cancer Volume: 132(2) Pages: 345-354
  • DOI: 10.1002/ijc.27682
  • Peer Reviewed
• [Journal Article] "Clinical Trial of the Intratumoral Administration of Labeled DC Combined With Systemic Chemotherapy for Esophageal Cancer (2013)
  • Author(s): Fujiwara, S., Wada, H., Miyata, H., Kawada, J., Kawabata, R., Nishikawa, H., Gnjatic, S., Sedrak, C., Sato, E., Nakamura, Y., Sakakibara, M., Kanto, T., Shimosegawa, E., Hatazawa, J., Takahashi, T., Kurokawa, Y., Yamasaki, M., Nakajima, K., Takiguchi, S., Nakayama, E., Mori, M.,and Doki, Y.
  • Journal Title: J Immunother Volume: 35(6) Pages: 345-354
  • DOI: 10.1097/cji.0b013e3182619cb4
  • Peer Reviewed
• [Journal Article] A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy. (2013)
  • Author(s): Gupta A
  • Journal Title: Cancer Immunity Volume: 13
  • Peer Reviewed
• [Journal Article] Antibody-based therapy in colorectal cancer (2013)
  • Author(s): Noguchi T
  • Journal Title: Immunotherapy Volume: In Press
  • Peer Reviewed
• [Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma. (2012)
  • Author(s): Nishikawa H.
  • Journal Title: Blood. Volume: 119(13) Pages: 3097-104
  • DOI: 10.1182/blood-2011-09-379982
  • Peer Reviewed
• [Journal Article] Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy. (2012)
  • Author(s): Noguchi, T., T.Kato, L.Wang, Y.Maeda, H.Ikeda, E.Sato, A.Knuth, S.Gnjatic, G.Ritter, S.Sakaguchi, L.J.Old, H.Shiku, H.Nishikawa
  • Journal Title: Cancer Res. Volume: 72 Pages: 1672-1682
  • DOI: 10.1158/0008-5472.can-11-3072
  • Peer Reviewed
• [Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors : a principal role for flt3 ligand in lymphopoiesis (2012)
  • Author(s): Nakamori Y, Liu B, Ohishi K, Suzuki K, Ino K, Matsumoto T, Masuya M, Nishikawa H, Shiku H, Hamada H, Katayama N
  • Journal Title: Br J Haematol Volume: 157(6) Pages: 674-686
  • DOI: 10.1111/j.1365-2141.2012.09109.x
• [Journal Article] Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma (2012)
  • Author(s): Suzuki S
  • Journal Title: Cancer Sci Volume: 103 Pages: 1764-1773
  • DOI: 10.1111/j.1349-7006.2012.02371.x
  • Peer Reviewed
• [Journal Article] Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor α 2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele (2012)
  • Author(s): Iwami K, Shimato S, Ohno M, Okada H, Nakahara N, Sato Y, Yoshida J, Suzuki S, Nishikawa H, Shiku H, Natsume A, Wakabayashi T
  • Journal Title: Cytotherapy Volume: 14 (6) Pages: 733-742
  • DOI: 10.3109/14653249.2012.666633
• [Journal Article] Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination (2012)
  • Author(s): Kawada J, Wada H, Isobe M, Gnjatic S, Nishikawa H, Jungbluth AA, Okazaki N, Uenaka A, Nakamura Y, Fujiwara S, Mizuno N, Saika T, Ritter E, Yamasaki M, Miyata M, Ritter G, Murphy R, Hoffman EW, Pan L, Old LJ, Doki Y, Nakayama E
  • Journal Title: Int J Cancer Volume: 130 Pages: 584-592
  • DOI: 10.1002/ijc.26074
  • Peer Reviewed
• [Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors : A principal role for flt3 ligand in lymphopoiesis (2012)
  • Author(s): Nakamori Y, et al共著者11名中8番目
  • Journal Title: British Journal of Haematology Volume: (掲載確定)(未定)
  • Peer Reviewed
• [Journal Article] Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor α chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele (2012)
  • Author(s): Iwami K, et al共著者12名中9番目
  • Journal Title: Cytotherapy Volume: (掲載確定)(未定)
  • Peer Reviewed
• [Journal Article] UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific CTL responses (2011)
  • Author(s): Toda M, Wang L, Ogura S, Torii M, Kurachi M, Kakimi K, Nishikawa H, Matsushima K, Shiku H, Kuribayashi K, Kato T
  • Journal Title: Int J Cancer Volume: 129(5) Pages: 1126-1136
  • DOI: 10.1002/ijc.25775
  • Peer Reviewed
• [Presentation] Control of Regulatory T cells in anti-tumor immunity (2014)
  • Author(s): Nishikawa H
  • Organizer: The 29 th Nagoya International Cancer Treatment Symposium シンポジウム
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2014-02-09
• [Presentation] Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells and augments anti-tumor immune responses in humans (2013)
  • Author(s): Sugiyama D, Nishikawa H, Maeda Y, Nishioka M, Tanemura A, Katayama I, Ezoe S, Kanakura Y, Sato E, Fukumori Y, Karbach J, Jager E and Shakaguchi S
  • Organizer: 21st Annual CRI International Cancer Immunotherapy Symposium
  • Place of Presentation: 米国ニューヨーク市
• [Presentation] エフェクター型制御性T細胞の選択的除去による抗原特異的免疫応答の増強 (2013)
  • Author(s): 杉山大介, 西川博嘉, 前田優香, 西岡めぐみ, 種村 篤, 片山一朗, 江副幸子, 金倉譲, 坂口志文
  • Organizer: 第17回日本がん免疫学会
  • Place of Presentation: 山口県宇部市
• [Presentation] TLR4アゴニストとしてOK-432を併用したNY-ESO-1長鎖重複ペプチドワクチン臨床試験 (2013)
  • Author(s): 長瀬博次、和田 尚、磯部みどり、垣見和宏、溝手 雄、榮川伸吾、黒瀬浩史、大植祥弘、西川博嘉、森 正樹、土岐裕一郎、岡 三喜男、中山睿一
  • Organizer: 第17回日本がん免疫学会
  • Place of Presentation: 山口県宇部市
• [Presentation] NY-ESO-1重複長鎖ペプチドを用いたがんワクチン第１相臨床試験 (2013)
  • Author(s): 西塔卓郎、和田 尚、磯部みどり、垣見和宏、榮川伸吾、大植祥弘、西川博嘉、森 正樹、土岐裕一郎、岡三喜男、中山睿一
  • Organizer: 第72回日本癌学会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] NY-ESO-1fペプチドワクチンによる抗体・CD4・CD8T細胞免疫応答の誘導 (2013)
  • Author(s): 榮川伸吾、垣見和宏、磯部みどり、和田 尚、上中明子、葛島清隆、西川博嘉、鵜殿平一郎、岡三喜男、中山睿一
  • Organizer: 第72回日本癌学会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] がん免疫における制御性T細胞の役割 (2013)
  • Author(s): 西川博嘉
  • Organizer: 第26回日本バイオセラピィ学会シンポジウム
  • Place of Presentation: 岩手県盛岡市
  • Year and Date: 2013-12-06
• [Presentation] Regulatory T cells : Friends or foes for cancer (2013)
  • Author(s): Nishikawa H
  • Organizer: 18 th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2013-12-04
• [Presentation] Selective depletion of effector-type CD4+regulatory T cells efficiently induces anti-tumor immune responses (2013)
  • Author(s): 杉山大介, 西川博嘉, 前田優香, 西岡めぐみ, 種村 篤, 片山一朗, 江副幸子, 金倉譲, 坂口志文
  • Organizer: 第72回日本癌学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2013-10-04
• [Presentation] NY-ESO-1重複長鎖ペプチドを用いたがんワクチン第1相臨床試験 (2013)
  • Author(s): 西塔卓郎, 和田 尚, 磯部みどり, 垣見和宏, 榮川伸吾, 大植祥弘, 西川博嘉, 森 正樹, 土岐裕一郎, 岡三喜男, 中山睿一
  • Organizer: 第72回日本癌学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2013-10-04
• [Presentation] NY-ESO-1f ペプチドワクチンによる抗体・ CD4 ・ CD8T細胞免疫応答の誘導 (2013)
  • Author(s): 榮川伸吾, 垣見和宏, 磯部みどり, 和田 尚, 上中明子, 葛島清隆, 西川博嘉, 鵜殿平一郎, 岡三喜男, 中山睿一
  • Organizer: 第72回日本癌学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2013-10-04
• [Presentation] Treg による免疫抑制の基礎 (2013)
  • Author(s): 西川博嘉
  • Organizer: 第22回日本組織適合性学会 シンポジウム
  • Place of Presentation: 福島県福島市
  • Year and Date: 2013-09-15
• [Presentation] 制御性T細胞を標的としたがん免疫療法 (2013)
  • Author(s): 西川博嘉
  • Organizer: 第29回日本皮膚悪性腫瘍学会シンポジウム
  • Place of Presentation: 山梨県甲府市
  • Year and Date: 2013-08-09
• [Presentation] Potential of combination immunotherapy targeting regulatory T cells (2013)
  • Author(s): Nishikawa H
  • Organizer: Cancer Immunotherapy Consortium
  • Place of Presentation: 米国ワシントン DC
  • Year and Date: 2013-04-25
• [Presentation] 成人T細胞白血病患者における免疫応答 (2012)
  • Author(s): 西川博嘉
  • Organizer: 第60回日本ウィルス学会
  • Place of Presentation: 大阪国際会議場
  • Invited
• [Presentation] Immunosuppression by regulatory T cells in malignant melanoma (2012)
  • Author(s): 前田優香
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Effects of corticosteroids on tumor immunity induced by CTLA-4 blockade depends on dose and timing (2012)
  • Author(s): Daisuke SUGIYAMA
  • Organizer: Cancer Immunotherapy 2012
  • Place of Presentation: 米国 ニューヨーク市 Millennium Conference Center
• [Presentation] Immunosuppression by regulatory T cells in malignant melanoma (2012)
  • Author(s): Yuka MAEDA
  • Organizer: Cancer Immunotherapy 2012
  • Place of Presentation: 米国 ニューヨーク市 Millennium Conference Center
• [Presentation] Regulatory T cells in anti-tumor immunity (2012)
  • Author(s): Hiroyoshi NISHIKAWA
  • Organizer: 第71回日本癌学会 Lloyd J Old Memorial Symposium
  • Place of Presentation: ロイトン札幌
  • Invited
• [Presentation] 抗CTLA-4抗体治療におけるステロイド剤投与量と投与時期の重要性 (2012)
  • Author(s): 杉山大介
  • Organizer: 第71回日本癌学会
  • Place of Presentation: ロイトン札幌
• [Presentation] 制御性T細胞を標的としたがん免疫療法の開発 (2012)
  • Author(s): 西川博嘉
  • Organizer: 第16回日本がん免疫学会
  • Place of Presentation: 北海道大学 学術交流会館
  • Invited
• [Presentation] 制御性T細胞による疾患制御 (2012)
  • Author(s): 西川博嘉
  • Organizer: 第77回日本インターフェロン・サイトカイン学会
  • Place of Presentation: 神戸商工会議所
  • Invited
• [Presentation] Immunosuppression by regulatory T cells in malignant melanoma (2012)
  • Author(s): 前田 優香, 西川 博嘉, 種村 篤, 西岡めぐみ, 杉山 大介, 片山 一朗, 坂口 志文
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2012-12-06
• [Presentation] 成人T細胞白血病患者における免疫応答ー免疫療法への応用の可能性ー (2012)
  • Author(s): 西川博嘉
  • Organizer: 第60回日本ウィルス学会 教育講演
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2012-11-14
• [Presentation] Effects of corticosteroids on tumor immunity induced by CTLA-4 blockade depends on dose and timing (2012)
  • Author(s): Sugiyama D, Maeda Y, Yuan J, Kato T, Sakaguchi S, Shiku H, Old LJ, Wolchok JD, Nishikawa H
  • Organizer: Cancer Immunotherapy
  • Place of Presentation: 米国ニューヨーク市
  • Year and Date: 2012-10-02
• [Presentation] Immunosuppression by regulatory T cells in malignant melanoma (2012)
  • Author(s): Maeda Y, Nishikawa H, Tanemura A, Sugiyama D, Katayama I, Sakaguchi S
  • Organizer: Cancer Immunotherapy
  • Place of Presentation: 米国ニューヨーク市
  • Year and Date: 2012-10-02
• [Presentation] Regulatory T cells in anti-tumor immunity (2012)
  • Author(s): 西川博嘉
  • Organizer: 第71回日本癌学会Lloyd J Oldメモリアルシンポジウム
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2012-09-20
• [Presentation] 制御性T細胞を標的としたがん免疫療法の開発 (2012)
  • Author(s): 西川博嘉
  • Organizer: 第16回日本がん免疫学会 シンポジウム
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2012-07-28
• [Presentation] 抗CTLA-4抗体治療におけるステロイド剤投与量と投与時期の重要性 (2012)
  • Author(s): 前田 優香, 杉山 大介, Jianda Yuan ,加藤 琢磨, 坂口 志文, 珠玖 洋, Lloyd J Old , Jedd D Wolchok, 西川博嘉
  • Organizer: 第16回日本がん免疫学会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2012-07-28
• [Presentation] 制御性T細胞による疾患制御 (2012)
  • Author(s): 西川博嘉,坂口志文
  • Organizer: 第77回日本インターフェロン・サイトカイン学会 シンポジウム
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2012-06-22
• [Presentation] Defining novel targets of immunotherapy for adult T-cell leukemia/lymphoma (2011)
  • Author(s): Maeda Y , Nishikawa H , Ishida T , Sacha G , Mori F , Sugiyama D , Ito A , Old LJ , Ueda R , Sakaguchi S
  • Organizer: The 19th Meeting in the Cancer Research Institute, International Cancer Immunotherapy Symposium Series
  • Place of Presentation: 米国ニューヨーク市
• [Presentation] NY-ESO-1癌ワクチン患者における血清学的「Antigen Spreading」現象 (2011)
  • Author(s): 和田尚, 磯辺みどり, Gnjatic Sacha, 西川博嘉, 上中明子, 中村ゆりか, 藤原進一, 秋武宏規, 山崎誠, 宮田博志, 土岐裕一郎, 中山睿一
  • Organizer: 日本癌学会
  • Place of Presentation: 愛知県名古屋市
• [Presentation] 術前化学療法を併用した樹状細胞局所投与臨床試験 (2011)
  • Author(s): 藤原進一, 和田尚, 宮田博志, 西川博嘉, 高橋剛, 黒川幸典, 山崎誠, 中島清一, 瀧口修司, 土岐裕一郎, 森正樹
  • Organizer: 日本癌学会
  • Place of Presentation: 愛知県名古屋市
• [Presentation] プロテインアレイを使用したCHP-MAGEA4ワクチンにより誘導される液性免疫応答の解析 (2011)
  • Author(s): 宮原慶祐, 堀早穂子, 前田優香, 西川博嘉, 上田修吾, 宮本正樹, 五島直樹, 川上和孝, 藤田知信, 河上裕, 池田裕明, 影山慎一, 珠玖洋
  • Organizer: 日本癌学会
  • Place of Presentation: 愛知県名古屋市
• [Presentation] Regulatory T cells in anti-tumor immunity (2011)
  • Author(s): Nishikawa H
  • Organizer: The Second CSI/JSI/KSI Joint Symposium on Immunology
  • Place of Presentation: 大阪大学銀杏会館(大阪)(招待講演)
• [Presentation] Effects of corticosteroids on tumor immunity induced by CTLA-4 blockade depends on dose and timing (2011)
  • Author(s): Sugiyama D, Maeda Y, Yuan J, Kato T, Sakaguchi S, Shiku H, Old LJ, Wolchok JD, Nishikawa H
  • Organizer: The 19^<th> Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Series
  • Place of Presentation: The Millennium Conference Center(米国ニューヨーク市)
• [Presentation] Defining novel targets of immunotherapy against adult T-cell leukemia/lymphoma (2011)
  • Author(s): Maeda Y, Nishikawa H, Ishida T, Gnjatic S, Mori F, Sugiyama D, Ito A, Old LJ, Ueda R, Sakaguchi S
  • Organizer: The 19^<th> Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Series
  • Place of Presentation: The Millennium Conference Center(米国ニューヨーク市)
• [Presentation] 成人T細胞白血病における細胞性免疫応答の解析 (2011)
  • Author(s): 西川博嘉、前田優香、石田高司、伊藤旭、森芙美子、上田龍三、坂口志文
  • Organizer: 第15回日本がん免疫学会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] 皮膚悪性黒色腫局所における制御性T細胞の免疫抑制機構の解析 (2011)
  • Author(s): 前田優香、西川博嘉、種村篤、杉山大介、片山一朗、坂口志文
  • Organizer: 第15回日本がん免疫学会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] 慢性炎症微小環境のおけるIL-17産生γδT細胞制御機構とその発がんへの関与 (2011)
  • Author(s): 脇田大功、角田健一郎、佐藤崇之、寺田聖、西川博嘉、岩倉洋一郎、北村秀光、西村孝司
  • Organizer: 第15回日本がん免疫学会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] プロテインアレイを使用したCHP-MAGEA4ワクチンにより誘導される液性免疫応答の解析 (2011)
  • Author(s): 宮原慶祐、堀早穂子、前田優香、西川博嘉、上田修吾、宮本正樹、五島直樹、川上和孝、藤田知信、河上裕、池田裕明、影山慎一、珠玖洋
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場(愛知)
• [Presentation] NY-ESO-1癌ワクチン患者における血清学的「Antigen Spreading」現象 (2011)
  • Author(s): 和田尚、磯辺みどり Gnjatic Sacha、西川博嘉、上中明子、中村ゆりか、藤原進一、秋武宏規、山崎誠、宮田博志、土岐裕一郎、中山睿一
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場(愛知)
• [Presentation] 術前化学療法を併用した樹状細胞局所投与臨床試験 (2011)
  • Author(s): 藤原進一、和田尚、宮田博志、西川博嘉、高橋剛、黒川幸典、山崎誠、中島清一、瀧口修司、土岐裕一郎、森正樹
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場(愛知)
• [Presentation] IL-17産生γδT細胞を介した炎症性発がん機構とその遺伝子支配 (2011)
  • Author(s): 脇田大功、角田健一郎、佐藤崇之、寺田聖、岩倉洋一郎、西川博嘉、北村秀光、西村孝司
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場(愛知)
• [Presentation] Comprehensive analyses of humoral and cellular immune responses against cancer/testis antigens in adult T-cell leukemia/lymphoma patients (2011)
  • Author(s): Nishikawa H, Maeda Y, Ishida T, Sugiyama D, Ito A, Mori F, Ueda R, Sakaguchi S
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉)
• [Presentation] Possible roles of regulatory T cells for the development of exhausted type CD8+T cells in human melanoma tissue (2011)
  • Author(s): Maeda Y, Nishikawa H, Tanemura A, Sugiyama D, Katayama I, Sakaguchi S
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉)
• [Presentation] Genetic control of chronic inflammation mediated by IL-17-producing γδT cells during carcinogenesis (2011)
  • Author(s): Wakita, D, Sumida K, Satoh T, Terada S, Iwakura Y, Nishikawa H, Kitamura H, Nishimura T
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉)
• [Presentation] Comprehensive analyses of humoral and cellular immune responses against cancer/testis antigens in adult T cell leukemia/lymphoma patients (2011)
  • Author(s): Nishikawa H , Maeda Y , Ishida T , Sugiyama D , Ito A , Mori F , Ueda R and Sakaguchi S
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉県千葉市
  • Year and Date: 2011-11-27
• [Presentation] Possible roles of regulatory T cells for the development of exhausted type CD8+ T cells in human melanoma tissue (2011)
  • Author(s): Maeda Y, Nishikawa H, Tanemura A, Sugiyama D, Katayama I, Sakaguchi S
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉県千葉市
  • Year and Date: 2011-11-27
• [Presentation] 成人T細胞性白血病患者における液性免疫応答の網羅的解析 (2011)
  • Author(s): 西川博嘉, 前田優香, 石田高司, 伊藤 旭,森, 芙美子, 上田龍三, 坂口志文
  • Organizer: 日本がん免疫学会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2011-07-01
• [Presentation] 皮膚悪性黒色腫局所における制御性T細胞の免疫抑制機構の解析 (2011)
  • Author(s): 前田優香, 西川博嘉, 種村 篤, 杉山大介, 片山一朗, 坂口志文
  • Organizer: 日本がん免疫学会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2011-07-01
• [Presentation] Regulatory T cells for tumor immunity Science in Japan (2011)
  • Author(s): Nishikawa H
  • Organizer: Forum
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2011-06-21
• [Presentation] Regulatory T cells for tumor immunity (2011)
  • Author(s): Nishikawa H
  • Organizer: Science in Japan Forum
  • Place of Presentation: Cosmos Club(米国ワシントンDC)(招待講演)
  • Year and Date: 2011-06-21
• [Presentation] Potential of combination immunotherapy targeting regulatory T cells
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: Cancer Immunotherapy Consortium
  • Place of Presentation: 米国ワシントンDC
  • Invited
• [Presentation] 制御性T細胞を標的としたがん免疫療法
  • Author(s): 西川博嘉
  • Organizer: 第29回日本皮膚悪性腫瘍学会
  • Place of Presentation: 山梨県甲府市
  • Invited
• [Presentation] Tregによる免疫抑制の基礎
  • Author(s): 西川博嘉
  • Organizer: 第22回日本組織適合性学会
  • Place of Presentation: 福島県福島市
  • Invited
• [Presentation] Regulatory T cells: Friends or foes for cancer
  • Author(s): Nishikawa H, Sakaguchi S
  • Organizer: 18th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
  • Place of Presentation: 東京都
  • Invited
• [Presentation] がん免疫における制御性T細胞の役割
  • Author(s): 西川博嘉
  • Organizer: 第26回日本バイオセラピィ学会
  • Place of Presentation: 岩手県盛岡市
  • Invited
• [Presentation] Harnessing regulatory T cells in anti-tumor immunity
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 千葉県千葉市
  • Invited
• [Presentation] Accumulation of CD4+Foxp3+ Treg cells is positively correlated with appearance of exhaustion-like phenotype in tumor-infiltrating CD8+ T cells
  • Author(s): Addegbe D, Sugiyama D, Nishikawa H, Sakaguchi S
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 千葉県千葉市
• [Presentation] Control of Regulatory T cells in anti-tumor immunity
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: The 29th Nagoya International Cancer Treatment Symposium
  • Place of Presentation: 愛知県名古屋市
  • Invited
• [Book] 免疫学コア講義 (2012)
  • Author(s): 西川博嘉
  • Publisher: 南山堂
• [Remarks]
  • URL: http://www.ifrec.osaka-u.ac.jp/index.php
• [Remarks] 大阪大学免疫学フロンティア研究センター
  • URL: http://www.ifrec.osaka-u.ac.jp/index.php