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Analysis of suppressive mechanisms by regulatory T cells

Research Project

Project/Area Number 23300354
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor immunology
Research InstitutionOsaka University

Principal Investigator

NISHIKAWA Hiroyoshi  大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (10444431)

Co-Investigator(Renkei-kenkyūsha) DOKI Yuichiro  大阪大学, 大学院・医学系研究科, 教授 (20291445)
TANEMURA Atsushi  大阪大学, 大学院・医学系研究科, 助教 (50457016)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords癌 / 制御性T細胞 / 抗腫瘍免疫応答 / CD4+制御性T細胞 / エフェクターT細胞
Research Abstract

The phenotypes and characteristics of regulatory T (Treg) cells in tumors were investigated. Treg cells infiltrating into tumors exhibited effector Treg-cell phenotypes and highly expressed CC chemokine receptor 4 (CCR4). Selective depletion of effector-type Tregs by targeting CCR4 induced/augmented cancer antigen-specific CD4+ and CD8+ T-cell responses. In addition, analysis of CD8+ T cells suppressed by Treg cells an unveiled hitherto undefined T-cell phenotype, suggesting a novel mechanism of Treg-cell suppression.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (87 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 21 results) Presentation (61 results) (of which Invited: 11 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Regulatory T cells in cancer immunotherapy2014

    • Author(s)
      Nishikawa H, Sakaguchi S
    • Journal Title

      Curr Opin Immunol

      Volume: 27 Pages: 1-7

    • DOI

      10.1016/j.coi.2013.12.005

    • NAID

      130004696113

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vaccination With NY-ESO-1 Overlapping Peptides Mixed With Picibanil OK-432 and Montanide ISA-51 in Patients With Cancers Expressing the NY-ESO-1 Antigen2014

    • Author(s)
      Wada H, Isobe M, Kakimi K, Mizote Y, Eikawa S, Sato E, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Yamasaki M, Miyata H, Matsushita H, Udono H, Seto Y, Yamada K, Nishikawa H, Pan L, Venhaus R, Oka M, Doki Y, Nakayama E.
    • Journal Title

      J Immunother

      Volume: 37(2) Issue: 2 Pages: 84-92

    • DOI

      10.1097/cji.0000000000000017

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking anti-tumor immune responses in humans2013

    • Author(s)
      Sugiyama D, Nishikawa H, Maeda Y, Nishioka M, Tanemura A, Katayama I, Ezoe S, Kanakura Y, Sato E, Fukumori Y, Karbach J, Jager E and Shakaguchi S
    • Journal Title

      Proc. Natl. Acad Sci USA

      Volume: 110(44) Issue: 44 Pages: 17945-17950

    • DOI

      10.1073/pnas.1316796110

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota2013

    • Author(s)
      Koji Atarashi, Takeshi Tanoue, et al.
    • Journal Title

      Nature

      Volume: 500 Issue: 7461 Pages: 232-236

    • DOI

      10.1038/nature12331

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes2013

    • Author(s)
      Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old LJ, Gnjatic S, and Shiku H
    • Journal Title

      Eur J Immunol

      Volume: 43 (4) Issue: 4 Pages: 989-1000

    • DOI

      10.1002/eji.201242800

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural and Induced T regulatory cells in Cancer2013

    • Author(s)
      Dennis Adeegbe and Hiroyoshi Nishikawa
    • Journal Title

      Frontiers in Immunology

      Volume: 4 Pages: 41-640

    • DOI

      10.3389/fimmu.2013.00190

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antibody-based therapy in colorectal cancer2013

    • Author(s)
      Noguchi T, Ritter G, Nishikawa H
    • Journal Title

      Immunotherapy

      Volume: 5(5) Issue: 5 Pages: 533-545

    • DOI

      10.2217/imt.13.35

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8+ T cells2013

    • Author(s)
      Muraoka D, Nishikawa H, Noguchi T, Wang L, Harada N, Sato E, Luescher I, Nakayama E, Kato T, Shiku H
    • Journal Title

      Vaccine

      Volume: 31(17) Issue: 17 Pages: 2110-2118

    • DOI

      10.1016/j.vaccine.2013.02.056

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NY-ESO-1 antibody as a novel tumour marker of gastric cancer.2013

    • Author(s)
      Fujiwara S, Wada H, Kawada J, Kawabata R, Takahashi T, Fujita J, Hirao T, Shibata K, Makari Y, Iijima S, Nishikawa H, Jungbluth AA, Nakamura Y, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Nakayama E, Mori M, Doki Y.
    • Journal Title

      Br J Cancer

      Volume: 108(5) Issue: 5 Pages: 1119-1125

    • DOI

      10.1038/bjc.2013.51

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy2013

    • Author(s)
      Liu B, Ohishi K, Orito Y,N a k a mo r i Y, Nishikawa H, Ino K,Suzuki K, Matsumoto T,Masuya M,Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N.
    • Journal Title

      Exp Hematol

      Volume: - Issue: 4 Pages: 367-376

    • DOI

      10.1016/j.exphem.2012.12.001

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.2013

    • Author(s)
      Eikawa, S., Kakimi, K., Idobe, M., Kuzushima, K., Luescher, I., Ohue, Y., Ikeuchi, K., Uenaka, A., Nishikawa, H., Udono, H., Oka, M., and Nakayama, E.
    • Journal Title

      Int. J. Cancer

      Volume: 132(2) Issue: 2 Pages: 345-54

    • DOI

      10.1002/ijc.27682

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy.2013

    • Author(s)
      Gupta A
    • Journal Title

      Cancer Immunity

      Volume: 13

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibody-based therapy in colorectal cancer2013

    • Author(s)
      Noguchi T
    • Journal Title

      Immunotherapy

      Volume: In Press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T cell leukemia/lymphoma2012

    • Author(s)
      Nishikawa H.
    • Journal Title

      Blood

      Volume: 119(13) Issue: 13 Pages: 3097-104

    • DOI

      10.1182/blood-2011-09-379982

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy2012

    • Author(s)
      Noguchi, T., T.Kato, L.Wang, Y.Maeda, H.Ikeda, E.Sato, A.Knuth, S.Gnjatic, G.Ritter, S.Sakaguchi, L.J.Old, H.Shiku, H.Nishikawa
    • Journal Title

      Cancer Research

      Volume: 72 Issue: 7 Pages: 1672-1682

    • DOI

      10.1158/0008-5472.can-11-3072

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors : a principal role for flt3 ligand in lymphopoiesis2012

    • Author(s)
      Nakamori Y, Liu B, Ohishi K, Suzuki K, Ino K, Matsumoto T, Masuya M, Nishikawa H, Shiku H, Hamada H, Katayama N
    • Journal Title

      Br J Haematol

      Volume: 157(6) Issue: 6 Pages: 674-686

    • DOI

      10.1111/j.1365-2141.2012.09109.x

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical trial of the intratumoral administration of labeled DC combined with systemic chemotherapy for esophageal cancer.2012

    • Author(s)
      Fujiwara, S., Wada, H., Miyata, H., Kawada, J., Kawabata, R., Nishikawa, H., Gnjatic, S., Sedrak, C., Sato, E., Nakamura, Y., Sakakibara, M., Kanto, T., Shimosegawa, E., Hatazawa, J., Takahashi, T., Kurokawa, Y., Yamasaki, M., Nakajima, K., Takiguchi, S., Nakayama, E., Mori, M.,and Doki, Y.
    • Journal Title

      J. Immunotherapy

      Volume: 35(6) Issue: 6 Pages: 513-521

    • DOI

      10.1097/cji.0b013e3182619cb4

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma.2012

    • Author(s)
      Suzuki S
    • Journal Title

      Cancer Sci.

      Volume: 103 Issue: 10 Pages: 1764-73

    • DOI

      10.1111/j.1349-7006.2012.02371.x

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor α 2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele2012

    • Author(s)
      Iwami K, Shimato S, Ohno M, Okada H, Nakahara N, Sato Y, Yoshida J, Suzuki S, Nishikawa H, Shiku H, Natsume A, Wakabayashi T
    • Journal Title

      Cytotherapy

      Volume: 14 (6) Issue: 6 Pages: 733-742

    • DOI

      10.3109/14653249.2012.666633

    • Related Report
      2013 Final Research Report
  • [Journal Article] Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination2012

    • Author(s)
      Kawada J, Wada H, Isobe M, Gnjatic S, Nishikawa H, Jungbluth AA, Okazaki N, Uenaka A, Nakamura Y, Fujiwara S, Mizuno N, Saika T, Ritter E, Yamasaki M, Miyata M, Ritter G, Murphy R, Hoffman EW, Pan L, Old LJ, Doki Y, Nakayama E
    • Journal Title

      Int J Cancer

      Volume: 130 Issue: 3 Pages: 584-592

    • DOI

      10.1002/ijc.26074

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors : A principal role for flt3 ligand in lymphopoiesis2012

    • Author(s)
      Nakamori Y, et al共著者11名中8番目
    • Journal Title

      British Journal of Haematology

      Volume: (掲載確定)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor α chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele2012

    • Author(s)
      Iwami K, et al共著者12名中9番目
    • Journal Title

      Cytotherapy

      Volume: (掲載確定)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses2011

    • Author(s)
      Toda M, Wang L, Ogura S, Torii M, Kurachi M, Kakimi K, Nishikawa H, Matsushima K, Shiku H, Kuribayashi K, Kato T
    • Journal Title

      International journal of cancer

      Volume: 129(5) Issue: 5 Pages: 1126-36

    • DOI

      10.1002/ijc.25775

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Control of Regulatory T cells in anti-tumor immunity2014

    • Author(s)
      Nishikawa H
    • Organizer
      The 29 th Nagoya International Cancer Treatment Symposium シンポジウム
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2014-02-09
    • Related Report
      2013 Final Research Report
  • [Presentation] がん免疫における制御性T細胞の役割2013

    • Author(s)
      西川博嘉
    • Organizer
      第26回日本バイオセラピィ学会シンポジウム
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2013-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory T cells : Friends or foes for cancer2013

    • Author(s)
      Nishikawa H
    • Organizer
      18 th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy シンポジウム
    • Place of Presentation
      東京都
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Selective depletion of effector-type CD4+regulatory T cells efficiently induces anti-tumor immune responses2013

    • Author(s)
      杉山大介, 西川博嘉, 前田優香, 西岡めぐみ, 種村 篤, 片山一朗, 江副幸子, 金倉譲, 坂口志文
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-10-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] NY-ESO-1重複長鎖ペプチドを用いたがんワクチン第1相臨床試験2013

    • Author(s)
      西塔卓郎, 和田 尚, 磯部みどり, 垣見和宏, 榮川伸吾, 大植祥弘, 西川博嘉, 森 正樹, 土岐裕一郎, 岡三喜男, 中山睿一
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] NY-ESO-1f ペプチドワクチンによる抗体・ CD4 ・ CD8T細胞免疫応答の誘導2013

    • Author(s)
      榮川伸吾, 垣見和宏, 磯部みどり, 和田 尚, 上中明子, 葛島清隆, 西川博嘉, 鵜殿平一郎, 岡三喜男, 中山睿一
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Treg による免疫抑制の基礎2013

    • Author(s)
      西川博嘉
    • Organizer
      第22回日本組織適合性学会 シンポジウム
    • Place of Presentation
      福島県福島市
    • Year and Date
      2013-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 制御性T細胞を標的としたがん免疫療法2013

    • Author(s)
      西川博嘉
    • Organizer
      第29回日本皮膚悪性腫瘍学会シンポジウム
    • Place of Presentation
      山梨県甲府市
    • Year and Date
      2013-08-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Potential of combination immunotherapy targeting regulatory T cells2013

    • Author(s)
      Nishikawa H
    • Organizer
      Cancer Immunotherapy Consortium
    • Place of Presentation
      米国ワシントン DC
    • Year and Date
      2013-04-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells and augments anti-tumor immune responses in humans2013

    • Author(s)
      Sugiyama D, Nishikawa H, Maeda Y, Nishioka M, Tanemura A, Katayama I, Ezoe S, Kanakura Y, Sato E, Fukumori Y, Karbach J, Jager E and Shakaguchi S
    • Organizer
      21st Annual CRI International Cancer Immunotherapy Symposium
    • Place of Presentation
      米国ニューヨーク市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] エフェクター型制御性T細胞の選択的除去による抗原特異的免疫応答の増強2013

    • Author(s)
      杉山大介, 西川博嘉, 前田優香, 西岡めぐみ, 種村 篤, 片山一朗, 江副幸子, 金倉譲, 坂口志文
    • Organizer
      第17回日本がん免疫学会
    • Place of Presentation
      山口県宇部市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] TLR4アゴニストとしてOK-432を併用したNY-ESO-1長鎖重複ペプチドワクチン臨床試験2013

    • Author(s)
      長瀬博次、和田 尚、磯部みどり、垣見和宏、溝手 雄、榮川伸吾、黒瀬浩史、大植祥弘、西川博嘉、森 正樹、土岐裕一郎、岡 三喜男、中山睿一
    • Organizer
      第17回日本がん免疫学会
    • Place of Presentation
      山口県宇部市
    • Related Report
      2013 Annual Research Report
  • [Presentation] NY-ESO-1重複長鎖ペプチドを用いたがんワクチン第1相臨床試験2013

    • Author(s)
      西塔卓郎、和田 尚、磯部みどり、垣見和宏、榮川伸吾、大植祥弘、西川博嘉、森 正樹、土岐裕一郎、岡三喜男、中山睿一
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] NY-ESO-1fペプチドワクチンによる抗体・CD4・CD8T細胞免疫応答の誘導2013

    • Author(s)
      榮川伸吾、垣見和宏、磯部みどり、和田 尚、上中明子、葛島清隆、西川博嘉、鵜殿平一郎、岡三喜男、中山睿一
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Immunosuppression by regulatory T cells in malignant melanoma2012

    • Author(s)
      前田 優香, 西川 博嘉, 種村 篤, 西岡めぐみ, 杉山 大介, 片山 一朗, 坂口 志文
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 成人T細胞白血病患者における免疫応答ー免疫療法への応用の可能性ー2012

    • Author(s)
      西川博嘉
    • Organizer
      第60回日本ウィルス学会 教育講演
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2012-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of corticosteroids on tumor immunity induced by CTLA-4 blockade depends on dose and timing2012

    • Author(s)
      Sugiyama D, Maeda Y, Yuan J, Kato T, Sakaguchi S, Shiku H, Old LJ, Wolchok JD, Nishikawa H
    • Organizer
      Cancer Immunotherapy
    • Place of Presentation
      米国ニューヨーク市
    • Year and Date
      2012-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Immunosuppression by regulatory T cells in malignant melanoma2012

    • Author(s)
      Maeda Y, Nishikawa H, Tanemura A, Sugiyama D, Katayama I, Sakaguchi S
    • Organizer
      Cancer Immunotherapy
    • Place of Presentation
      米国ニューヨーク市
    • Year and Date
      2012-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory T cells in anti-tumor immunity2012

    • Author(s)
      西川博嘉
    • Organizer
      第71回日本癌学会Lloyd J Oldメモリアルシンポジウム
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 制御性T細胞を標的としたがん免疫療法の開発2012

    • Author(s)
      西川博嘉
    • Organizer
      第16回日本がん免疫学会 シンポジウム
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2012-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗CTLA-4抗体治療におけるステロイド剤投与量と投与時期の重要性2012

    • Author(s)
      前田 優香, 杉山 大介, Jianda Yuan ,加藤 琢磨, 坂口 志文, 珠玖 洋, Lloyd J Old , Jedd D Wolchok, 西川博嘉
    • Organizer
      第16回日本がん免疫学会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2012-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 制御性T細胞による疾患制御2012

    • Author(s)
      西川博嘉,坂口志文
    • Organizer
      第77回日本インターフェロン・サイトカイン学会 シンポジウム
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2012-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 成人T細胞白血病患者における免疫応答2012

    • Author(s)
      西川博嘉
    • Organizer
      第60回日本ウィルス学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Immunosuppression by regulatory T cells in malignant melanoma2012

    • Author(s)
      前田優香
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of corticosteroids on tumor immunity induced by CTLA-4 blockade depends on dose and timing2012

    • Author(s)
      Daisuke SUGIYAMA
    • Organizer
      Cancer Immunotherapy 2012
    • Place of Presentation
      米国 ニューヨーク市 Millennium Conference Center
    • Related Report
      2012 Annual Research Report
  • [Presentation] Immunosuppression by regulatory T cells in malignant melanoma2012

    • Author(s)
      Yuka MAEDA
    • Organizer
      Cancer Immunotherapy 2012
    • Place of Presentation
      米国 ニューヨーク市 Millennium Conference Center
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulatory T cells in anti-tumor immunity2012

    • Author(s)
      Hiroyoshi NISHIKAWA
    • Organizer
      第71回日本癌学会 Lloyd J Old Memorial Symposium
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 抗CTLA-4抗体治療におけるステロイド剤投与量と投与時期の重要性2012

    • Author(s)
      杉山大介
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 制御性T細胞を標的としたがん免疫療法の開発2012

    • Author(s)
      西川博嘉
    • Organizer
      第16回日本がん免疫学会
    • Place of Presentation
      北海道大学 学術交流会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 制御性T細胞による疾患制御2012

    • Author(s)
      西川博嘉
    • Organizer
      第77回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      神戸商工会議所
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Comprehensive analyses of humoral and cellular immune responses against cancer/testis antigens in adult T cell leukemia/lymphoma patients2011

    • Author(s)
      Nishikawa H , Maeda Y , Ishida T , Sugiyama D , Ito A , Mori F , Ueda R and Sakaguchi S
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉県千葉市
    • Year and Date
      2011-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Possible roles of regulatory T cells for the development of exhausted type CD8+ T cells in human melanoma tissue2011

    • Author(s)
      Maeda Y, Nishikawa H, Tanemura A, Sugiyama D, Katayama I, Sakaguchi S
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉県千葉市
    • Year and Date
      2011-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 成人T細胞性白血病患者における液性免疫応答の網羅的解析2011

    • Author(s)
      西川博嘉, 前田優香, 石田高司, 伊藤 旭,森, 芙美子, 上田龍三, 坂口志文
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-07-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮膚悪性黒色腫局所における制御性T細胞の免疫抑制機構の解析2011

    • Author(s)
      前田優香, 西川博嘉, 種村 篤, 杉山大介, 片山一朗, 坂口志文
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-07-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory T cells for tumor immunity Science in Japan2011

    • Author(s)
      Nishikawa H
    • Organizer
      Forum
    • Place of Presentation
      米国ワシントンDC
    • Year and Date
      2011-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory T cells for tumor immunity2011

    • Author(s)
      Nishikawa H
    • Organizer
      Science in Japan Forum
    • Place of Presentation
      Cosmos Club(米国ワシントンDC)(招待講演)
    • Year and Date
      2011-06-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Defining novel targets of immunotherapy for adult T-cell leukemia/lymphoma2011

    • Author(s)
      Maeda Y , Nishikawa H , Ishida T , Sacha G , Mori F , Sugiyama D , Ito A , Old LJ , Ueda R , Sakaguchi S
    • Organizer
      The 19th Meeting in the Cancer Research Institute, International Cancer Immunotherapy Symposium Series
    • Place of Presentation
      米国ニューヨーク市
    • Related Report
      2013 Final Research Report
  • [Presentation] NY-ESO-1癌ワクチン患者における血清学的「Antigen Spreading」現象2011

    • Author(s)
      和田尚, 磯辺みどり, Gnjatic Sacha, 西川博嘉, 上中明子, 中村ゆりか, 藤原進一, 秋武宏規, 山崎誠, 宮田博志, 土岐裕一郎, 中山睿一
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] 術前化学療法を併用した樹状細胞局所投与臨床試験2011

    • Author(s)
      藤原進一, 和田尚, 宮田博志, 西川博嘉, 高橋剛, 黒川幸典, 山崎誠, 中島清一, 瀧口修司, 土岐裕一郎, 森正樹
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] プロテインアレイを使用したCHP-MAGEA4ワクチンにより誘導される液性免疫応答の解析2011

    • Author(s)
      宮原慶祐, 堀早穂子, 前田優香, 西川博嘉, 上田修吾, 宮本正樹, 五島直樹, 川上和孝, 藤田知信, 河上裕, 池田裕明, 影山慎一, 珠玖洋
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory T cells in anti-tumor immunity2011

    • Author(s)
      Nishikawa H
    • Organizer
      The Second CSI/JSI/KSI Joint Symposium on Immunology
    • Place of Presentation
      大阪大学銀杏会館(大阪)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of corticosteroids on tumor immunity induced by CTLA-4 blockade depends on dose and timing2011

    • Author(s)
      Sugiyama D, Maeda Y, Yuan J, Kato T, Sakaguchi S, Shiku H, Old LJ, Wolchok JD, Nishikawa H
    • Organizer
      The 19^<th> Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Series
    • Place of Presentation
      The Millennium Conference Center(米国ニューヨーク市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Defining novel targets of immunotherapy against adult T-cell leukemia/lymphoma2011

    • Author(s)
      Maeda Y, Nishikawa H, Ishida T, Gnjatic S, Mori F, Sugiyama D, Ito A, Old LJ, Ueda R, Sakaguchi S
    • Organizer
      The 19^<th> Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Series
    • Place of Presentation
      The Millennium Conference Center(米国ニューヨーク市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成人T細胞白血病における細胞性免疫応答の解析2011

    • Author(s)
      西川博嘉、前田優香、石田高司、伊藤旭、森芙美子、上田龍三、坂口志文
    • Organizer
      第15回日本がん免疫学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 皮膚悪性黒色腫局所における制御性T細胞の免疫抑制機構の解析2011

    • Author(s)
      前田優香、西川博嘉、種村篤、杉山大介、片山一朗、坂口志文
    • Organizer
      第15回日本がん免疫学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性炎症微小環境のおけるIL-17産生γδT細胞制御機構とその発がんへの関与2011

    • Author(s)
      脇田大功、角田健一郎、佐藤崇之、寺田聖、西川博嘉、岩倉洋一郎、北村秀光、西村孝司
    • Organizer
      第15回日本がん免疫学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロテインアレイを使用したCHP-MAGEA4ワクチンにより誘導される液性免疫応答の解析2011

    • Author(s)
      宮原慶祐、堀早穂子、前田優香、西川博嘉、上田修吾、宮本正樹、五島直樹、川上和孝、藤田知信、河上裕、池田裕明、影山慎一、珠玖洋
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] NY-ESO-1癌ワクチン患者における血清学的「Antigen Spreading」現象2011

    • Author(s)
      和田尚、磯辺みどり Gnjatic Sacha、西川博嘉、上中明子、中村ゆりか、藤原進一、秋武宏規、山崎誠、宮田博志、土岐裕一郎、中山睿一
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 術前化学療法を併用した樹状細胞局所投与臨床試験2011

    • Author(s)
      藤原進一、和田尚、宮田博志、西川博嘉、高橋剛、黒川幸典、山崎誠、中島清一、瀧口修司、土岐裕一郎、森正樹
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17産生γδT細胞を介した炎症性発がん機構とその遺伝子支配2011

    • Author(s)
      脇田大功、角田健一郎、佐藤崇之、寺田聖、岩倉洋一郎、西川博嘉、北村秀光、西村孝司
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comprehensive analyses of humoral and cellular immune responses against cancer/testis antigens in adult T-cell leukemia/lymphoma patients2011

    • Author(s)
      Nishikawa H, Maeda Y, Ishida T, Sugiyama D, Ito A, Mori F, Ueda R, Sakaguchi S
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Possible roles of regulatory T cells for the development of exhausted type CD8+T cells in human melanoma tissue2011

    • Author(s)
      Maeda Y, Nishikawa H, Tanemura A, Sugiyama D, Katayama I, Sakaguchi S
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic control of chronic inflammation mediated by IL-17-producing γδT cells during carcinogenesis2011

    • Author(s)
      Wakita, D, Sumida K, Satoh T, Terada S, Iwakura Y, Nishikawa H, Kitamura H, Nishimura T
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Potential of combination immunotherapy targeting regulatory T cells

    • Author(s)
      Hiroyoshi Nishikawa
    • Organizer
      Cancer Immunotherapy Consortium
    • Place of Presentation
      米国ワシントンDC
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 制御性T細胞を標的としたがん免疫療法

    • Author(s)
      西川博嘉
    • Organizer
      第29回日本皮膚悪性腫瘍学会
    • Place of Presentation
      山梨県甲府市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Tregによる免疫抑制の基礎

    • Author(s)
      西川博嘉
    • Organizer
      第22回日本組織適合性学会
    • Place of Presentation
      福島県福島市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Regulatory T cells: Friends or foes for cancer

    • Author(s)
      Nishikawa H, Sakaguchi S
    • Organizer
      18th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] がん免疫における制御性T細胞の役割

    • Author(s)
      西川博嘉
    • Organizer
      第26回日本バイオセラピィ学会
    • Place of Presentation
      岩手県盛岡市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Harnessing regulatory T cells in anti-tumor immunity

    • Author(s)
      Hiroyoshi Nishikawa
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      千葉県千葉市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Accumulation of CD4+Foxp3+ Treg cells is positively correlated with appearance of exhaustion-like phenotype in tumor-infiltrating CD8+ T cells

    • Author(s)
      Addegbe D, Sugiyama D, Nishikawa H, Sakaguchi S
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      千葉県千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Control of Regulatory T cells in anti-tumor immunity

    • Author(s)
      Hiroyoshi Nishikawa
    • Organizer
      The 29th Nagoya International Cancer Treatment Symposium
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 免疫学コア講義2012

    • Author(s)
      西川博嘉
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.ifrec.osaka-u.ac.jp/index.php

    • Related Report
      2013 Final Research Report
  • [Remarks] 大阪大学免疫学フロンティア研究センター

    • URL

      http://www.ifrec.osaka-u.ac.jp/index.php

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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