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Development of a tailor-made molecular targeted oncologic diagnostic imaging using a newly-developed amino acid PET tracer.

Research Project

Project/Area Number 23300360
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor diagnosis
Research InstitutionResearch Institute, Shiga Medical Center

Principal Investigator

HIGASHI Tatsuya  滋賀県立成人病センター(研究所), その他部局等, その他 (50324629)

Co-Investigator(Kenkyū-buntansha) NISHII Ryuichi  宮崎大学, 医学部, 講師 (60463212)
KAGAWA Shinya  滋賀県立成人病センター(研究所), 主任研究員 (10393191)
OOMOMO Yoshiro  大阪薬科大学, 薬学部, 准教授 (70183241)
Project Period (FY) 2011-11-18 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords癌 / 放射線画像診断 / 薬学 / テーラーメード治療 / 分子標的 / テーラーメイド医療 / 分子イメージング / PET / アミノ酸輸送システム / PET検査 / 酢酸イメージング / 肝臓腫瘍 / 前立腺腫瘍
Research Abstract

We developed and had a success of the radio-synthesis method of [18F]NMeFAMP and the results of the synthesis was quite excellent with yield evaluation about 20%, synthesis time about 90 min, radiochemical purity > 99.9%. However, we could not move ahead to quality control test, acute toxicity test, etc. On the other hand, we had successful results in the radio-synthesis methods of [18F]FACE using newly-introduced solid phase extraction techniques, two-pot distillation and one-pot distillation methods. With these techniques, we can provide [18F]FACE radio-synthesis methods with higher quality, cheaper, and more simple process, as compared to the traditional on-column hydrolysis method. After the approval of our ethical committee, we performed a human PET study with liver tumor patients using [18F]FACE and [18F]FDG, and the results were published by a well-known medical journal, Annals of Nuclear Medicine.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (39 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (35 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Assessment of [18F]-fluoroacetate PET/CT as a tumor-imaging modality : preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor2014

    • Author(s)
      Takemoto K, Hatano E, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Matsumura K, Zaima M, Toriguchi K, Tanabe K, Kitamura K, Seo S, Taura K, Endo K, Uemoto S, Higashi T
    • Journal Title

      Ann Nucl Med

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Assessment of [18F]-fluoroacetate PET/CT as a tumor-imaging modality: preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor.2014

    • Author(s)
      ① Takemoto K, Hatano E, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Matsumura K, Zaima M, Toriguchi K, Tanabe K, Kitamura K, Seo S, Taura K, Endo K, Uemoto S, Higashi T.
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 28 Issue: 4 Pages: 371-380

    • DOI

      10.1007/s12149-014-0823-z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic usefulness of an amino acid tracer, α-[N-methyl- ^11C]-methylaminoisobutyric acid ( ^<11>C-MeAIB), in the PET diagnosis of chest malignancies2013

    • Author(s)
      Nishii R, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Motoyama H, Kawakami K, Nakaoku T, Nohara J, Okamura M, Watanabe T, Nakatani K, Nagamachi S, Tamura S, Kawai K, Kobayashi M
    • Journal Title

      Ann Nucl Med

      Volume: 27(9) Issue: 9 Pages: 808-21

    • DOI

      10.1007/s12149-013-0750-4

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 新しい固相抽出技術を用いた[^<18>F]Fluoroacetate ([^<18>F]FACE) 合成法の検討2013

    • Author(s)
      加川信也, 西井龍一, 東達也, 山内 浩, 高橋和弘, 水間広, 尾上浩隆, 竹本研史, 波多野悦郎, 川井恵一
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場, 博多, 福岡
    • Year and Date
      2013-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Oncologic diagnosis of liver tumors using [^<18>F]-fluoroacetate PET/CT as compared to [^<18>F]-fluorodeoxyglucose PET/CT2013

    • Author(s)
      Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano
    • Organizer
      Initial experience. EANM2013. Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      Lyon, France
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] [^<18>F]Fluoroacetate ([18F]FACE) 臨床研究に向けて2013

    • Author(s)
      加川 信也, 矢倉 栄幸, 西井 龍一, 東 達也, 岸辺 喜彦, 高橋 昌章, 山内 浩, 水川 陽介, 竹本 研史, 波多野 悦郎, 高橋 和弘, 水間 広, 尾上 浩隆, 川井 恵一
    • Organizer
      PETサマーセミナー2013
    • Place of Presentation
      金沢日航ホテル, 金沢, 石川
    • Year and Date
      2013-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 腫瘍PET診断-post-FDGの将来展望-2013

    • Author(s)
      東 達也
    • Organizer
      横浜市立大学・群馬大学放射線診断核医学講座共催 第2回YG Conference( 特別講演 )
    • Place of Presentation
      ニューサンピア高崎, 高崎, 群馬
    • Year and Date
      2013-08-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Assessment of [^<18>F]-Fluoroacetate PET/CT as a tumor-imaging modality : Comparison with [^<18>F]-FDG in patients with liver tumor and in healthy volunteers2013

    • Author(s)
      Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano
    • Organizer
      60th Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2013-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 核医学診断・治療の臨床 現状と展望2013

    • Author(s)
      東 達也
    • Organizer
      神戸薬科大学特別研究セミナー(教育講演)
    • Place of Presentation
      神戸薬科大学, 神戸市, 兵庫
    • Year and Date
      2013-03-07
    • Related Report
      2013 Final Research Report
  • [Presentation] PET 薬剤合成の勘所 : [^<18>F] フルオロ酢酸2013

    • Author(s)
      加川信也
    • Organizer
      PET化学ワークショップ2013 (シンポジスト)
    • Place of Presentation
      由布院,大分県
    • Year and Date
      2013-02-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel approach for solid-phase radiosynthesis of ^<18>F-Fluoroacetate : Comparison between one-pot and two-pot distillation procedure2013

    • Author(s)
      Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Keiichi Kawai
    • Organizer
      The Society of Nuclear Medicine and Molecular Imaging (SNMMI) 60th Annual Meeting
    • Place of Presentation
      VANCOUVER, BC, CANADA
    • Related Report
      2013 Final Research Report
  • [Presentation] Radiosynthesis of [^<18>F]Fluoroacetate by a one-pot distillation procedure : a novel approach of the solid-phase synthesis2013

    • Author(s)
      Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Etsuro Hatano, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Shigeki Nagamachi, Keiichi Kawai, Shozo Tamura
    • Organizer
      The 20th International Symposium on Radiopharmaceutical Sciences (ISRS)
    • Place of Presentation
      ICC JEJU, Jeju, KOREA
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい固相抽出技術を用いた[18F]Fluoroacetate ([18F]FACE)合成法の検討。2013

    • Author(s)
      ① 加川信也、西井龍一、東達也、山内 浩、高橋和弘、水間広、尾上浩隆、竹本研史、波多野悦郎、川井恵一
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場、博多、福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Oncologic diagnosis of liver tumors using [18F]-fluoroacetate PET/CT as compared to [18F]-fluorodeoxyglucose PET/CT. Initial experience.2013

    • Author(s)
      ② Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano.
    • Organizer
      EANM2013. Annual Congress of the European Association of Nuclear Medicine.
    • Place of Presentation
      Lyon, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] [18F]Fluoroacetate ([18F]FACE)臨床研究に向けて。2013

    • Author(s)
      ③ 加川 信也、矢倉 栄幸、西井 龍一、東 達也、岸辺 喜彦、高橋 昌章、山内 浩、水川 陽介、竹本 研史、波多野 悦郎、高橋 和弘、水間 広、尾上 浩隆、川井 恵一。
    • Organizer
      PETサマーセミナー2013
    • Place of Presentation
      金沢日航ホテル、金沢、石川
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Assessment of [18F]-Fluoroacetate PET/CT as a tumor-imaging modality: Comparison with [18F]-FDG in patients with liver tumor and in healthy volunteers.2013

    • Author(s)
      ④ Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano.
    • Organizer
      60th Annual Meeting of Society of Nuclear Medicine.
    • Place of Presentation
      Vancouver, Canada.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel approach for solid-phase radiosynthesis of 18F-Fluoroacetate: Comparison between one-pot and two-pot distillation procedure.2013

    • Author(s)
      ⑤ Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Keiichi Kawai.
    • Organizer
      60th Annual Meeting of Society of Nuclear Medicine.
    • Place of Presentation
      Vancouver, Canada.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Radiosynthesis of [18F]Fluoroacetate by a one-pot distillation procedure: a novel approach of the solid-phase synthesis.2013

    • Author(s)
      ⑥ Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Etsuro Hatano, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Shigeki Nagamachi, Keiichi Kawai, Shozo Tamura.
    • Organizer
      The 20th International Symposium on Radiopharmaceutical Sciences (ISRS).
    • Place of Presentation
      Jeju, KOREA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腫瘍PET診断 -post-FDGの将来展望-2013

    • Author(s)
      東 達也
    • Organizer
      横浜市立大学・群馬大学放射線診断核医学講座共催 第2回YG Conference
    • Place of Presentation
      ニューサンピア高崎、高崎、群馬
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Radiosynthesis of [^<18>F]Fluoroacetate : Comparison between on-column hydrolysis method and two-pot distillation procedure using a cassette-type multipurpose automatic synthesizer module2012

    • Author(s)
      Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroyo Araki, Hiroyuki Okudaira, Tomoya Uehara, Masato Kobayashi, Mitsuyoshi Yoshimoto, Yasushi Arano, Keiichi Kawai
    • Organizer
      European Association of Nuclear Medicine ( EANM ) Congress 2012
    • Place of Presentation
      Milan, Italia
    • Year and Date
      2012-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] [^<18>F]Fluoroacetateの合成法の開発 : オンカラム加水分解法とtwo-pot蒸留法の比較2012

    • Author(s)
      加川信也, 西井龍一, 東達也, 岸辺喜彦, 高橋昌章, 高橋和弘, 水間広, 尾上浩隆, 竹本研史, 川井恵一, 山内浩
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌, 札幌市, 北海道
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] アミノ酸ポジトロン製剤MeAIBによる前立腺癌PET診断-FDG, MRI との比較検討-2012

    • Author(s)
      東達也, 西井龍一, 加川信也, 岸辺喜彦, 高橋昌章, 山内浩, 石戸谷哲, 植村祐一, 牛田博, 大西裕之
    • Organizer
      第52回日本核医学会 学術総会
    • Place of Presentation
      ロイトン札幌, 札幌市, 北海道
    • Year and Date
      2012-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] アミノ酸ポジトロン製剤 MeAIB を用いた胸部腫瘍 PET 診断2012

    • Author(s)
      東達也, 西井龍一, 加川信也, 岸辺喜彦, 高橋昌章, 山内浩
    • Organizer
      第52回日本核医学会 学術総会
    • Place of Presentation
      ロイトン札幌, 札幌市, 北海道
    • Year and Date
      2012-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] がん診療におけるPETの現状と将来展望2012

    • Author(s)
      東 達也
    • Organizer
      滋賀県立成人病センター第3回がん診療グランドセミナー(教育講演)
    • Place of Presentation
      滋賀県立成人病センター研究所講堂, 守山, 滋賀
    • Year and Date
      2012-09-29
    • Related Report
      2013 Final Research Report
  • [Presentation] アミノ酸ポジトロン製剤MeAIBを用いた胸部腫瘍PET診断の経験2012

    • Author(s)
      東達也, 西井龍一, 加川信也, 岸辺喜彦, 高橋昌章
    • Organizer
      第45回日本核医学会近畿地方会
    • Place of Presentation
      メルパルク京都, 京都
    • Year and Date
      2012-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 腫瘍 PET と核医学治療-overview-2012

    • Author(s)
      東 達也
    • Organizer
      群馬大学放射線診断核医学講座 第257回Open Film Conference( 特別講演 )
    • Place of Presentation
      群馬大学医学部臨床中講堂, 前橋, 群馬
    • Year and Date
      2012-07-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Assessment of efficacy of [^<11>C]-MeAIB PET/CT as a biomarker of the system A amino acid transport : Comparison with [^<18>F]-FDG and MRI in the patients with prostate cancer2012

    • Author(s)
      Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Satoshi Ishitoya, Hiroshi Ushida, Yuichi Uemura, Hiroyuki Oonishi, Keiichi Kawai, Masato Kobayashi
    • Organizer
      59th Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      Miami, Florida, USA
    • Year and Date
      2012-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる縦隔腫瘍PET診断2012

    • Author(s)
      東達也, 加川信也, 法幸由起子, 川上賢三, 中奥敬史, 野原淳, 渡辺寿規, 中谷光一
    • Organizer
      第4回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      プラザ淡海, 大津市, 滋賀
    • Year and Date
      2012-02-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 臨床使用に向けた[^<18>F]Fluoroacetate ([^<18>F]FACE )製造法の検討2012

    • Author(s)
      加川信也, 矢倉栄幸, 西井龍一, 東達也, 山内浩, 水川陽介, 竹本研史, 波多野悦郎, 高橋和弘, 水間広, 尾上浩隆, 長町茂樹, 川井恵一, 田村正三
    • Organizer
      第七回日本分子イメージング学会
    • Place of Presentation
      アクトシティ浜松, 浜松, 静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Assessment of efficacy of [11C]-MeAIB PET/CT as a biomarker of the system A amino acid transport: Comparison with [18F]-FDG and MRI in the patients with prostate cancer.2012

    • Author(s)
      東 達也、西井龍一、加川信也 他
    • Organizer
      第59回米国核医学会総会
    • Place of Presentation
      米国フロリダ州マイアミ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Usefulness of system A amino acid transport PET imaging with C-11-MeAIB in diagnosing brain tumors: A comparison study with C-11-Methionin PET imaging.2012

    • Author(s)
      西井龍一、東 達也、加川信也 他
    • Organizer
      第59回米国核医学会総会
    • Place of Presentation
      米国フロリダ州マイアミ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤 MeAIB による前立腺癌 PET 診断 -FDG, MRI との比較検討による中間報告 -2011

    • Author(s)
      東達也, 加川信也, 岸辺喜彦, 高橋昌章, 山内浩, 石戸谷哲, 植村祐一, 大西裕之, 南俊介, 西井龍一, 川井恵一
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場, つくば, 茨城
    • Year and Date
      2011-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] PET腫瘍診断薬 [^<18>F]Fluoroacetate の合成基礎検討2011

    • Author(s)
      加川信也, 西井龍一, 東達也, 岸辺喜彦, 高橋昌章, 山内浩, 竹本研史, 波多野悦郎, 長町茂樹, 川井恵一, 田村正三
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場, つくば, 茨城
    • Year and Date
      2011-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝胆膵疾患における腫瘍 PET 診断2011

    • Author(s)
      東 達也,波多野悦朗
    • Organizer
      第9回日本消化器外科学会大会 第82回日本消化器内視鏡学会総会 第19回日本消化器関連学会週間DDWJapan2011 ( 教育講演 )
    • Place of Presentation
      福岡国際センター, 博多, 福岡
    • Year and Date
      2011-10-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Usefulness of Double Tracer PET study using [^<18>F]FDG and Amino Acid Radiotracer, [^<11>C]MeAIB, in the Diagnosis of Mediastinal Diseases2011

    • Author(s)
      Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe,Keiichi Kawai, Masato Kobayashi
    • Organizer
      58th Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2011-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] F-18フルオロ酢酸のヒト肝細胞における集積検討2011

    • Author(s)
      加川信也, 西井龍一, 竹本研史, 東達也, 波多野悦郎, 水間広, 尾上浩隆, 長町茂樹, 川井恵一, 田村正三, Juri G Gerovani
    • Organizer
      第六回日本分子イメージング学会
    • Place of Presentation
      神戸国際会議場, 兵庫
    • Year and Date
      2011-05-26
    • Related Report
      2013 Final Research Report
  • [Presentation] アミノ酸ポジトロン製剤MeAIBを用いた胸部腫瘍PET診断

    • Author(s)
      東 達也、西井龍一、加川信也 他
    • Organizer
      第52回日本核医学会総会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] アミノ酸ポジトロン製剤MeAIBによる前立腺癌PET診断 ―FDG, MRIとの比較検討―

    • Author(s)
      東 達也、西井龍一、加川信也 他
    • Organizer
      第52回日本核医学会総会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.shigamed.jp/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-15   Modified: 2019-07-29  

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