| Budget Amount *help |
¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
The present research aimed to realize the induction heating cancer therapy, that involve delivers magnetic nano-particles to cancer nodules and eradicate cancer by heat using irradiation of alternating current magnetic field. For this purpose, iron nano particle with high heat productive power more than 500 W/g was indispensable, which was not available at the project start time, and we originally developed surface-modified iron nanoparticle (DINP). The successful production of this new iron nanoparticle were subjected to application of international patent. The surface modification of DINP by block-polymer PEG did not confer sufficient stealth effect which aimed to escape from capture by macrophage and Kupffer cells. The enhanced delivery of DINP by co-addministration of tumor specific penetrating peptide (iRGD) were also unsuccessful. Instead, we directly injected DINP into mouse xenograft and obtained complete eradication by induction heating.
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