| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Research Abstract |
We studied an effect of radiation on selective chromosome segregation and the relationship between the number of cells showing selective chromosome segregation and p53 expression in mouse neurosphere cells. The result revealed that the number of cells showing selective chromosome segregation was reduced depending on irradiated X-ray doses. This reduction may be related to the dose-dependent decrease in number of CD133 positive cells. In addition, the cells showing selective chromosome segregation were not observed in p53 knock out (KO) mouse neurosphere cells and the number of those cells was significantly reduced in p53 knock down (KD) neurosphere cells, suggesting that the p53 function is involved in the regulation of selective chromosome segregation.
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