Study of genetic effects of atomic bomb radiation using high-density microarray
| Project/Area Number |
23310042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
KODAIRA Mieko 公益財団法人放射線影響研究所, 遺伝学部, 研究員 (60344412)
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| Co-Investigator(Kenkyū-buntansha) |
ASAKAWA Jun-ichi (公財)放射線影響研究所, 遺伝学部, 主任研究員 (10359458)
FURUKAWA Kyoji (公財)放射線影響研究所, 統計部, 副主任研究員 (00416421)
NAKAMURA Nori (公財)放射線影響研究所, 遺伝学部, 顧問 (00010116)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 原爆放射線の遺伝的影響 / 生殖細胞突然変異 / アレイCGH法による突然変異検索 / 突然変異の分子レベルの特徴 / 原爆被爆者の家族解析 / 全ゲノムスクリーニング / アレイCGH解析 / コピー数変異突然変異 / 生殖細胞突然変異率 / アレイCGH / 突然変異 / HD アレイ-CGH法 / 家族解析による突然変異検出 / アレイ-CGH法 / CNV検索 |
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| Outline of Final Research Achievements |
We have analyzed a total of 127 mother-father-child trios using high-density microarrays. We identified about 300 copy number variants (CNV) per individual genome. Eleven CNVs observed in 11 children were not identified among the parents and were thought to be de novo germline mutations. Seven of the mutations were deletions; one was 140kb deletion but the remaining 6 were small deletions (5kb-30kb). Our model experiments on F1 mice derived from irradiated spermatogonia revealed that one deletion, which size is larger than 100kb, was induced among approximately 100 genomes per 1 Gy of radiation. The results of the current study on the offspring of the A-bomb survivors suggest that the radio-sensitivity of humans are not different from that of mice and the genetic risk of radiation maybe much smaller than currently estimated.
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Report
(5 results)
Research Products
(18 results)
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[Presentation] ラット未熟卵子への放射線の影響2014
Author(s)
浅川順一、上口勇次郎、神谷研二、中村典
Organizer
第39回中国地区放射線影響研究会
Place of Presentation
広島大学医学部保健学科研究棟 （広島市）
Year and Date
2014-07-18
Related Report
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