| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
We have analyzed a total of 127 mother-father-child trios using high-density microarrays. We identified about 300 copy number variants (CNV) per individual genome. Eleven CNVs observed in 11 children were not identified among the parents and were thought to be de novo germline mutations. Seven of the mutations were deletions; one was 140kb deletion but the remaining 6 were small deletions (5kb-30kb). Our model experiments on F1 mice derived from irradiated spermatogonia revealed that one deletion, which size is larger than 100kb, was induced among approximately 100 genomes per 1 Gy of radiation. The results of the current study on the offspring of the A-bomb survivors suggest that the radio-sensitivity of humans are not different from that of mice and the genetic risk of radiation maybe much smaller than currently estimated.
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