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Study of genetic effects of atomic bomb radiation using high-density microarray

Research Project

Project/Area Number 23310042
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionRadiation Effects Research Foundation

Principal Investigator

KODAIRA Mieko  公益財団法人放射線影響研究所, 遺伝学部, 研究員 (60344412)

Co-Investigator(Kenkyū-buntansha) ASAKAWA Jun-ichi  (公財)放射線影響研究所, 遺伝学部, 主任研究員 (10359458)
FURUKAWA Kyoji  (公財)放射線影響研究所, 統計部, 副主任研究員 (00416421)
NAKAMURA Nori  (公財)放射線影響研究所, 遺伝学部, 顧問 (00010116)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords原爆放射線の遺伝的影響 / 生殖細胞突然変異 / アレイCGH法による突然変異検索 / 突然変異の分子レベルの特徴 / 原爆被爆者の家族解析 / 全ゲノムスクリーニング / アレイCGH解析 / コピー数変異突然変異 / 生殖細胞突然変異率 / アレイCGH / 突然変異 / HD アレイ-CGH法 / 家族解析による突然変異検出 / アレイ-CGH法 / CNV検索
Outline of Final Research Achievements

We have analyzed a total of 127 mother-father-child trios using high-density microarrays. We identified about 300 copy number variants (CNV) per individual genome. Eleven CNVs observed in 11 children were not identified among the parents and were thought to be de novo germline mutations. Seven of the mutations were deletions; one was 140kb deletion but the remaining 6 were small deletions (5kb-30kb). Our model experiments on F1 mice derived from irradiated spermatogonia revealed that one deletion, which size is larger than 100kb, was induced among approximately 100 genomes per 1 Gy of radiation. The results of the current study on the offspring of the A-bomb survivors suggest that the radio-sensitivity of humans are not different from that of mice and the genetic risk of radiation maybe much smaller than currently estimated.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (18 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (10 results) (of which Invited: 1 results) Remarks (6 results)

  • [Journal Article] Mutagenic effects of ionizing radiation on immature rat oocytes2014

    • Author(s)
      Asakawa J, Kamiguchi Y, Kamiya K, Nakamura N.
    • Journal Title

      Radiation Research

      Volume: 182 Issue: 4 Pages: 430-434

    • DOI

      10.1667/rr13776.1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The genetic risk in mice from radiation: An estimate of the mutation induction rate per genome2013

    • Author(s)
      Asakawa J, Kodaira M, Cullings HM, Katayama H, Nakamura N.
    • Journal Title

      Radiation Research

      Volume: 179 Issue: 3 Pages: 293-303

    • DOI

      10.1667/rr3095.1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット未熟卵子における放射線誘発突然変異:高密度マイクロアレイで検出された突然変異2014

    • Author(s)
      小平美江子、三浦昭子、今中正明、辻隆弘、北村淳、中本芳子、上口勇次郎、中村典、浅川順一
    • Organizer
      第57回 日本放射線影響学会
    • Place of Presentation
      かごしま県民交流センター (鹿児島市)
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高密度マイクロアレイCGH法を用いた原爆放射線の遺伝的影響調査2014

    • Author(s)
      三浦昭子、辻隆弘、今中正明、北村淳、金子順子、中本芳子、錦織栄子、佐藤康成、古川恭治、小平美江子、中村典、浅川順一
    • Organizer
      第57回 日本放射線影響学会
    • Place of Presentation
      かごしま県民交流センター (鹿児島市)
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] X線照射ヒト培養細胞クローンDNAの全ゲノム塩基配列解読で検出された突然変異2014

    • Author(s)
      浅川順一、藤本明洋、佐藤康成、三浦昭子、中本芳子、錦織栄子、今中正明、小平美江子
    • Organizer
      第57回 日本放射線影響学会
    • Place of Presentation
      かごしま県民交流センター (鹿児島市)
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 全ゲノムシーケンス法による放射線がマウス成熟卵母細胞に及ぼす遺伝的影響の評価2014

    • Author(s)
      佐藤康成、瀬々潤、西村まゆみ、島田義也、中村典、浅川順一
    • Organizer
      第57回 日本放射線影響学会
    • Place of Presentation
      かごしま県民交流センター (鹿児島市)
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mutations identified in cell clones derived from X-irradiated human cultured cells by whole genome sequencing2014

    • Author(s)
      SatohY, Fujimoto A, Asakawa J.
    • Organizer
      60th Annual Meeting of the Radiation Research Society
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2014-09-21 – 2014-09-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット未熟卵子への放射線の影響2014

    • Author(s)
      浅川順一、上口勇次郎、神谷研二、中村典
    • Organizer
      第39回中国地区放射線影響研究会
    • Place of Presentation
      広島大学医学部保健学科研究棟 (広島市)
    • Year and Date
      2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Whole exome sequencing based genetic study of radiation.2013

    • Author(s)
      浅川順一
    • Organizer
      NGS現場の会第三回研究会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウスを用いた放射線の遺伝的影響調査結果についての考察2012

    • Author(s)
      浅川順一、中村典
    • Organizer
      第55回日本放射線影響学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] 自然突然変異と放射線誘発突然変異は識別できるか?

    • Author(s)
      小平美江子、三浦昭子、今中正明、辻隆弘、中本芳子、西村まゆみ、島田義也、浅川順一
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] 原爆被爆者の子供における放射線の遺伝的影響 (放射線の遺伝的影響に関するDNA 調査)

    • Author(s)
      浅川順一
    • Organizer
      第35回日本がん疫学・分子疫学研究会総会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 蛋白質レベルの遺伝的影響調査とその後のDNA 調査

    • URL

      http://www.rerf.jp/shared/briefdescript/briefdescript_j.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 高密度マイクロアレイCGH法を用いた原爆放射線の遺伝的影響調査

    • URL

      http://www.rerf.jp/programs/rparchiv/rp04-11.htm

    • Related Report
      2014 Annual Research Report
  • [Remarks] 放射線誘発欠失突然変異頻度の推定

    • URL

      http://www.rerf.jp/library/AnnualReport/2013/pdf/2_FY2013%20Highlights%20in%20Research%20Progress.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 高密度マイクロアレイCGH法を用いた原爆放射線の遺伝的影響調査

    • URL

      http://www.rerf.or.jp/programs/rparchiv/rp04-11.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks] 高密度マイクロアレイCGH法を用いた原爆放射線の遺伝的影響調査

    • URL

      http://www.rerf.jp/programs/rparchiv/rp04-11.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks] 遺伝学部の研究活動 (RERF Update, p. 15)

    • URL

      http://www.rerf.jp/library/update/pdf/2012vol23J.pdf

    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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