Mechanism of sex-related difference and its toxicological significance in the toxic manifestation of inorganic arsenic

• Project/Area Number: 23310045
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: The University of Tokyo
• Principal Investigator: WATANABE Chiho 東京大学, 医学(系)研究科(研究院), 教授 (70220902)
• Co-Investigator(Kenkyū-buntansha): SATOH Masahiko 愛知学院大学, 薬学部, 教授 (20256390) ; INAOKA Tsukasa 佐賀大学, 農学部, 教授 (60176386) ; FURUSAWA Hana 東京大学, 医学系研究科, 助教 (80401032)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 人体有害物質 / 無機砒素 / 毒性への感受性 / 遺伝子多型 / セレン / 性差 / フィールド調査 / 実験研究 / ヒ素曝露 / メチル化代謝 / ネパール / バングラデシュ / 国際研究者交流 / マウス / 酸化ストレス / 砒素汚染地域 / ヒ素汚染地域

Research Abstract

Population at health risk posed by exposure to inorganic arsenic in the groundwater is estimated to be more than 50 million in the world. One of the striking features of inorganic arsenic toxicity is its distinct inter-individual and inter-population variation, which is associated with sex, genetic characteristics, and nutrition. We hypothesized that the effects of all of these susceptibility-associated factors can be ascribable to the difference in arsenic metabolism, and tried to prove this using both field survey and experimental approach. In the field we have conducted survey in three arsenic-contamination sites in South Asia. Major findings included that sex-associated difference in toxic manifestation of arsenic depended on the outcome that we are observing, and that the proportion of the most toxic metabolites (MMA) showed negative correlation with the concentration of selenium.

Research Products

• [Journal Article] Arsenic exposure increases maternal but not cord serum immunoglobulin G level (2014)
  • Author(s): Ping Han Ser, Bilkis Banu, Fatema Jebunnesa, Kaneez Fatema, Nasrin Rosy, Rabeya Yasmin, Hana Furusawa, Liaquat Ali, Akhtar Ahmad, Chiho Watanabe, PhD
  • Journal Title: Bangladesh Pediatrics International Volume: (in press)
  • Peer Reviewed
• [Presentation] バングラデシュのヒ素汚染地域住民における血漿中・尿中のヒ素およびセレン濃度の関連 (2013)
  • Author(s): 松野佑真 古澤華 稲岡司 渡辺知保
  • Organizer: 第78回日本民族衛生学会総会
  • Place of Presentation: 佐賀
• [Presentation] Effects of Arsenic on Expressions of Ube2d Family and Accumulation of p53 in Renal Tubular Cells and Vascular Endothelial Cells (2013)
  • Author(s): Satoh M., Lee J.Y., Tokumoto M., Fujiwara Y., Watanabe C
  • Organizer: The 52nd Annual Meeting of the Society of Toxicology
  • Place of Presentation: San Antonio, Texas. USA
• [Presentation] Effects of Arsenic on Expressions of Ube2d Family and Accumulation of p53 in NRK-52E Cells and HK-2 Cells (2013)
  • Author(s): Satoh M., Lee J.Y., Tokumoto M., Fujiwara Y., Watanabe C
  • Organizer: The VIII International Congress of Toxicology
  • Place of Presentation: Seoul, Korea
• [Presentation] Inorganic Arsenic-induced Oxidative Stress among Bangladeshi Population Exposed to High Arsenic through drinking water (2012)
  • Author(s): Sultana N et al
  • Organizer: The 6th International Congress of Asian Society of Toxicology
  • Place of Presentation: Sendai
  • Year and Date: 2012-07-19
• [Presentation] Arsenic induces p53-dependent apoptosis through the down-regulation of Ube2d family genes in renal tubular cells (2012)
  • Author(s): Satoh M. et al
  • Organizer: The 51st Annual Meeting of the Society of Toxicology
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2012-03-13
• [Presentation] Inorganic Arsenic-induced Oxidative Stress among Bangladeshi Population Exposed to High Arsenic Through Drinking Water (2012)
  • Author(s): Sultana N
  • Organizer: The 6th International Congress of Asian Society of Toxicology
  • Place of Presentation: 仙台国際センター，仙台市
• [Presentation] The Role of Gender in Inorganic Arsenic Induced Oxidative Stress Among Bangladeshi Population Exposed to High Arsenic Through Drinking Water (2011)
  • Author(s): Sultana N et al
  • Organizer: ISEE 2011 Conference
  • Place of Presentation: Barcelona - Spain
• [Presentation] The Role of Gender in Inorganic Arsenic Induced Oxidative Stress Among Bangladeshi Population Exposed to High Arsenic Through Drinking Water (2011)
  • Author(s): Sultana N, et al.
  • Organizer: ISEE 2011 Conference
  • Place of Presentation: Barcelona-Spain