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Mechanism of sex-related difference and its toxicological significance in the toxic manifestation of inorganic arsenic

Research Project

Project/Area Number 23310045
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionThe University of Tokyo

Principal Investigator

WATANABE Chiho  東京大学, 医学(系)研究科(研究院), 教授 (70220902)

Co-Investigator(Kenkyū-buntansha) SATOH Masahiko  愛知学院大学, 薬学部, 教授 (20256390)
INAOKA Tsukasa  佐賀大学, 農学部, 教授 (60176386)
FURUSAWA Hana  東京大学, 医学系研究科, 助教 (80401032)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords人体有害物質 / 無機砒素 / 毒性への感受性 / 遺伝子多型 / セレン / 性差 / フィールド調査 / 実験研究 / ヒ素曝露 / メチル化代謝 / ネパール / バングラデシュ / 国際研究者交流 / マウス / 酸化ストレス / 砒素汚染地域 / ヒ素汚染地域
Research Abstract

Population at health risk posed by exposure to inorganic arsenic in the groundwater is estimated to be more than 50 million in the world. One of the striking features of inorganic arsenic toxicity is its distinct inter-individual and inter-population variation, which is associated with sex, genetic characteristics, and nutrition. We hypothesized that the effects of all of these susceptibility-associated factors can be ascribable to the difference in arsenic metabolism, and tried to prove this using both field survey and experimental approach. In the field we have conducted survey in three arsenic-contamination sites in South Asia. Major findings included that sex-associated difference in toxic manifestation of arsenic depended on the outcome that we are observing, and that the proportion of the most toxic metabolites (MMA) showed negative correlation with the concentration of selenium.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (9 results)

All 2014 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results)

  • [Journal Article] Arsenic exposure increases maternal but not cord serum immunoglobulin G level2014

    • Author(s)
      Ping Han Ser, Bilkis Banu, Fatema Jebunnesa, Kaneez Fatema, Nasrin Rosy, Rabeya Yasmin, Hana Furusawa, Liaquat Ali, Akhtar Ahmad, Chiho Watanabe, PhD
    • Journal Title

      Bangladesh Pediatrics International

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] バングラデシュのヒ素汚染地域住民における血漿中・尿中のヒ素およびセレン濃度の関連2013

    • Author(s)
      松野佑真 古澤華 稲岡司 渡辺知保
    • Organizer
      第78回日本民族衛生学会総会
    • Place of Presentation
      佐賀
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of Arsenic on Expressions of Ube2d Family and Accumulation of p53 in Renal Tubular Cells and Vascular Endothelial Cells2013

    • Author(s)
      Satoh M., Lee J.Y., Tokumoto M., Fujiwara Y., Watanabe C
    • Organizer
      The 52nd Annual Meeting of the Society of Toxicology
    • Place of Presentation
      San Antonio, Texas. USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of Arsenic on Expressions of Ube2d Family and Accumulation of p53 in NRK-52E Cells and HK-2 Cells2013

    • Author(s)
      Satoh M., Lee J.Y., Tokumoto M., Fujiwara Y., Watanabe C
    • Organizer
      The VIII International Congress of Toxicology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Inorganic Arsenic-induced Oxidative Stress among Bangladeshi Population Exposed to High Arsenic through drinking water2012

    • Author(s)
      Sultana N et al
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Sendai
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Arsenic induces p53-dependent apoptosis through the down-regulation of Ube2d family genes in renal tubular cells2012

    • Author(s)
      Satoh M. et al
    • Organizer
      The 51st Annual Meeting of the Society of Toxicology
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2012-03-13
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Inorganic Arsenic-induced Oxidative Stress among Bangladeshi Population Exposed to High Arsenic Through Drinking Water2012

    • Author(s)
      Sultana N
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台国際センター,仙台市
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Role of Gender in Inorganic Arsenic Induced Oxidative Stress Among Bangladeshi Population Exposed to High Arsenic Through Drinking Water2011

    • Author(s)
      Sultana N et al
    • Organizer
      ISEE 2011 Conference
    • Place of Presentation
      Barcelona - Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] The Role of Gender in Inorganic Arsenic Induced Oxidative Stress Among Bangladeshi Population Exposed to High Arsenic Through Drinking Water2011

    • Author(s)
      Sultana N, et al.
    • Organizer
      ISEE 2011 Conference
    • Place of Presentation
      Barcelona-Spain
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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