| Project/Area Number |
23310045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | The University of Tokyo |
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Principal Investigator |
WATANABE Chiho 東京大学, 医学(系)研究科(研究院), 教授 (70220902)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Masahiko 愛知学院大学, 薬学部, 教授 (20256390)
INAOKA Tsukasa 佐賀大学, 農学部, 教授 (60176386)
FURUSAWA Hana 東京大学, 医学系研究科, 助教 (80401032)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 人体有害物質 / 無機砒素 / 毒性への感受性 / 遺伝子多型 / セレン / 性差 / フィールド調査 / 実験研究 / ヒ素曝露 / メチル化代謝 / ネパール / バングラデシュ / 国際研究者交流 / マウス / 酸化ストレス / 砒素汚染地域 / ヒ素汚染地域 |
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| Research Abstract |
Population at health risk posed by exposure to inorganic arsenic in the groundwater is estimated to be more than 50 million in the world. One of the striking features of inorganic arsenic toxicity is its distinct inter-individual and inter-population variation, which is associated with sex, genetic characteristics, and nutrition. We hypothesized that the effects of all of these susceptibility-associated factors can be ascribable to the difference in arsenic metabolism, and tried to prove this using both field survey and experimental approach. In the field we have conducted survey in three arsenic-contamination sites in South Asia. Major findings included that sex-associated difference in toxic manifestation of arsenic depended on the outcome that we are observing, and that the proportion of the most toxic metabolites (MMA) showed negative correlation with the concentration of selenium.
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