| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
Environmental concentration of organotins such as tributyltin is close to toxic concentration. In the present study, we examined in vitro mechanism of decrease of GluR2 (an AMPA type glutamate receptor subunit) and its in vivo effects. We clarified that tributyltin suppresses GluR2 expression by decreasing nuclear respiratory factor-1 (NRF-1) activity. Whereas, in in vivo study, GluR2 and brain-derived neurotrophic factor (BDNF) decreased in the cerebral cortex and the hippocampus in tributyltin-treated rats. BDNF is a regulating factor of GluR2 expression. Taken together, GluR2 decrease-induced neurotoxicity might be one of unresolved toxicities.
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