| Budget Amount *help |
¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Research Abstract |
Expression profile analysis using colon cancer cells treated with SMYD3-specific siRNA identified a total of 1543 genes (entities) that were significantly upregulated by SMYD3. Subsequent in silico analysis using MetaGP revealed that these genes are potentially controlled by 126 transcription factors. Combined with the data of ChIP on chip analysis using anti-SMYD3 antibody, we identified 110 candidates of target genes of SMYD3. In addition, gene ontology and gene set enrichment analyses elucidated that elevated SMYD3 expression is associated with cell cycle control. These data suggest that SMYD3 plays a crucial role in proliferation of cancer cells and that inhibition of its function should be a rational strategy to treat human cancers.
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