Analysis of the network constructed by dosage balanced genes in yeast
| Project/Area Number |
23310140
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
System genome science
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
MORIYA Hisao 岡山大学, その他部局等, 准教授 (60500808)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MAKINO Takashi 東北大学, 大学院・生命科学研究科, 准教授 (20443442)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | 遺伝子ネットワーク / タンパク質ネットワーク / 量感受性遺伝子 / 量的均衡遺伝子 / 酵母 / ゲノム / 過剰発現 / 遺伝子量不均衡 |
|---|
| Research Abstract |
Dosage balanced gene (DBG) is a gene whose expression is balanced against more than two genes, and the perturbation of the balance causes cellular dysfunction. Using a genetic method designated "genetic tug-of-war", we have been trying to identify "dosage sensitive genes" whose minor overexpression cause cellular dysfunction. In this study, we proceeded this analysis, and identified 115 dosage sensitive genes in the budding yeast genome. We further identified 13 dosage-balanced interactions. This study is the first example for the systematic identification of dosage sensitive genes in a organism's genome, and for the identification of multiple dosage balanced genes at a time.
|
Report
(4 results)
Research Products
(43 results)
