| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Research Abstract |
Dosage balanced gene (DBG) is a gene whose expression is balanced against more than two genes, and the perturbation of the balance causes cellular dysfunction. Using a genetic method designated "genetic tug-of-war", we have been trying to identify "dosage sensitive genes" whose minor overexpression cause cellular dysfunction. In this study, we proceeded this analysis, and identified 115 dosage sensitive genes in the budding yeast genome. We further identified 13 dosage-balanced interactions. This study is the first example for the systematic identification of dosage sensitive genes in a organism's genome, and for the identification of multiple dosage balanced genes at a time.
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