| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Research Abstract |
Cyclodepsipeptide natural products include optically active hydroxy acids as well as various unnatural amino acids and exhibit a variety of biological activity depending on the peptide sequence, chirality, and selection of the hydroxy acids. We have demonstrated (1) design and synthesis of peptide mimetics of apratoxin A and total synthesis of apratoxin C, (2) synthesis of water soluble telomestatin analogues that is as potent as telomestatin in telomerase inhibitory activity, (3) combinatorial synthesis of destruxin E analogues and their SAR study, (4) design and synthesis of peptide mimetics of beauveriolide III and synthesis of photoaffinity probes of beauveriolide III.
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