Intracellular glycoside signal participating in the regulation of biological phenomena

• Project/Area Number: 23310147
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Tohoku University
• Principal Investigator: UEDA Minoru 東北大学, 理学(系)研究科(研究院), 教授 (60265931)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 就眠運動 / ジャスモン酸グルコシド / 配糖体 / シグナル伝達 / ケミカルバイオロジー / ジャスモン酸 / ジャスモン酸配糖体 / 活性酸素 / グリコシド / 標的タンパク質 / Glycosylation Switching / 標的タンパク / cDNAライブラリー

Research Abstract

JAG induced motor cell shrinking and concomittant ROS production. External addition of ROS also induced motor-cell shrinking, thne JAG-induced shrinking of motor cell is independent to COI1-JAZ signaling pathway and dependent ROS-mediated path. The molecular target of JAG was also revealed by using our compact molecular probe approach.

Research Products

• [Journal Article] Syntnesis of methyl epi-anhydroquinate utilizing [2,3]-sigmatropic rearrangment of iodosoalkene (2013)
  • Author(s): SInomata.M.Ueda T.Sugai,M.Shoji
  • Journal Title: ChemLett Volume: 42 Pages: 1273-1275
  • Peer Reviewed
• [Journal Article] Fabricaion of Pure nanodrugs of podophyllotoxin Dimer and their Anticancer Activity (2013)
  • Author(s): Y.Ikuta,Y.Koseki,T.Murakami,M.Ueda, H.Oikawa,H.Kasai
  • Journal Title: ChemLett Volume: 42 Pages: 900-901
  • Peer Reviewed
• [Journal Article] 〓probe and its efficiency in affinity labeling of a target protein for jasmonate (2013)
  • Author(s): Tamura S, Inomata S, Ebine M, Genji T, Iwakura I, Mukai M, Shoji M, Sugai T, Ueda M
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 23 Issue: 1 Pages: 188-193
  • DOI: 10.1016/j.bmcl.2012.10.124
  • Peer Reviewed
• [Journal Article] Stereoselective Construction of cis-Decalin Framework via Radical Domino Cyclization (2013)
  • Author(s): E. Suzuki, M. Ueda, S. Ohba, T. Sugai, M. Shoji
  • Journal Title: Tetrahedron Lett Volume: 54 Pages: 1589-1592
  • Peer Reviewed
• [Journal Article] Stereoselective construction of cis-decalin framework via radical domino cyclization (2013)
  • Author(s): Eriko Suzuki, Minoru Ueda, Sigeru Ohba, Takeshi Sugai, Mitsuru Shoji
  • Journal Title: Tetrahedron Letters Volume: 54 Issue: 12 Pages: 1589-1592
  • DOI: 10.1016/j.tetlet.2013.01.050
  • Peer Reviewed
• [Journal Article] Synthesis of methyl epi-anhydroquinate utilizing [2,3]-sigmatropic rearrangment of iodosoalkene (2013)
  • Author(s): S. Inomata, M. Ueda, T. Sugai, M. Shoji
  • Journal Title: Chem. Lett. Volume: 42 Issue: 10 Pages: 1273-1275
  • DOI: 10.1246/cl.130612
  • NAID: 10031201336
  • Peer Reviewed
• [Journal Article] Fabrication of Pure Nanodrugs of Podophyllotoxin Dimer and Their Anticancer Activity (2013)
  • Author(s): Y. Ikuta, Y. Koseki, T. Murakami, M. Ueda, H. Oikawa, H. Kasai
  • Journal Title: Chem. Lett. Volume: 48 Issue: 8 Pages: 900-901
  • DOI: 10.1246/cl.130224
  • NAID: 10031189289
  • Peer Reviewed
• [Journal Article] Stereoselective Construction of cis-Decalin Framework via Radical Domino Cyclization, (2013)
  • Author(s): E. Suzuki, M. Ueda, S. Ohba, T. Sugai, M. Shoji
  • Journal Title: Tetrahedron Lett. Volume: 54 Pages: 1589-1592
  • Peer Reviewed
• [Journal Article] Creation of Pure Nanodrugs and Their Anticancer PropertiesAngew (2012)
  • Author(s): H. Kasai, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, M. Hashida
  • Journal Title: Chem. Int. Ed Volume: 51 Pages: 10315-10318
  • Peer Reviewed
• [Journal Article] Hybrid Stereoisomers of Compact Molecular Probes Based on Jasmonic Acid Glucoside: Syntheses and Biological Evaluations, (2012)
  • Author(s): M. Ueda, G. Yang, Y. Ishimaru, S. Tamura, T. Itabashi, K. Kiyota, S. Kuwahara, S. Inomata, M. Shoji, T. Sugai
  • Journal Title: Bioorg. Med. Chem., Volume: 20 Pages: 5832-5843
  • Peer Reviewed
• [Journal Article] Creation of Pure Nanodrugs and Their Anticancer Properties (2012)
  • Author(s): H. Kasai, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, M. Hashida
  • Journal Title: Angew. Chem. Int. Ed. Volume: 51 Pages: 10315-10318
  • Peer Reviewed
• [Journal Article] Cassia obtusifolia MetE as a Cytosolic Target for Potassium Isolespedezate, a Leaf-Opening Factor of Cassia plants : Target Exploration by a Compact Molecular-Probe Strategy (2011)
  • Author(s): Ueda, M.Manabe, Y.Otsuka, Y.Kanzawa, N.
  • Journal Title: Chem Asian J Volume: 6 Issue: 12 Pages: 3286-97
  • DOI: 10.1002/asia.201100392
  • Peer Reviewed
• [Journal Article] The high-performance of 3XFLAG for target purification of bioactive metabolite : a tag combined with highly effective linker structure (2011)
  • Author(s): M.Ueda, Y.Manabe, M.Mukai
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 21 Issue: 5 Pages: 1359-1362
  • DOI: 10.1016/j.bmcl.2011.01.038
  • Peer Reviewed
• [Journal Article] 12-Hydroxyjasmonic Acid Glucoside is a COI1-JAZs Independent Activator of Leaf Closing Movement in Samanea saman (2011)
  • Author(s): Y.Nakamura, A.Mithofer, E.Kombrink, W.Boland, S.Hamamoto, N.Uozumi, K.Tohma, M.Ueda
  • Journal Title: Plant Physiology Volume: 155 Issue: 3 Pages: 1226-1236
  • DOI: 10.1104/pp.110.168617
  • NAID: 130006997012
  • Peer Reviewed
• [Presentation] Chemistry and Biology of Plant Leaf-movement ナカニシシンポジウム (2014)
  • Author(s): 上田実
  • Organizer: 日本化学会第94 春季年会(2014)
  • Place of Presentation: 名古屋
  • Year and Date: 2014-03-27
• [Presentation] Chemistry and Biology of Nyctinastic Plant Movement (2014)
  • Author(s): Minoru Ueda
  • Organizer: Nakanishi Symposium
  • Place of Presentation: 名古屋大学
  • Invited
• [Presentation] 植物の就眠ならびに捕虫運動の制御機構の化学的解明(受賞講演/学会賞受賞) (2013)
  • Author(s): 上田実
  • Organizer: 植物化学調節学会第48回大会
  • Place of Presentation: 新潟
  • Year and Date: 2013-11-01
• [Presentation] 就眠運動に関わるアメリカネムノキのK+ チャネルの解析(ポスター) (2013)
  • Author(s): 及川貴也, 石丸泰寛, 浜本普, 魚住信之, 上田 実
  • Organizer: 植物化学調節学会第48回大会
  • Place of Presentation: 新潟
  • Year and Date: 2013-11-01
• [Presentation] アルキン型コロナチンの合成と in vivo ラマンイメージング(ポスター) (2013)
  • Author(s): 江越脩祐, 田下諒, 山越博幸, どど孝介, 石丸泰寛, 源治尚久, 袖岡幹子, 上田実
  • Organizer: 植物化学調節学会第48回大会
  • Place of Presentation: 新潟
  • Year and Date: 2013-10-31
• [Presentation] "Glycosylation Switching" : 生物に学ぶ新しい化学的活性制御 (2013)
  • Author(s): 上田実
  • Organizer: 第24回万有仙台シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2013-06-15
• [Presentation] "Glycosylation Switching"による天然物リガンドの活性制御 (2013)
  • Author(s): 上田実
  • Organizer: 日本化学会第93春期年会特別企画
  • Place of Presentation: 滋賀
  • Year and Date: 2013-03-22
  • Invited
• [Presentation] アルキン型コロナチンの合成と in vivo ラマンイメージング (2013)
  • Author(s): 江越脩祐、田下 諒、山越博幸、どど孝介、石丸泰寛、源治尚久、袖岡幹子、上田 実
  • Organizer: 植物化学調節学会第48回大会
  • Place of Presentation: 新潟大学
  • Invited
• [Presentation] 就眠運動に関わるアメリカネムノキのK+ チャネルの解析 (2013)
  • Author(s): 及川貴也、石丸泰寛、浜本 普、魚住信之、上田 実
  • Organizer: 植物化学調節学会第48回大会
  • Place of Presentation: 新潟大学
  • Invited
• [Presentation] 植物の就眠ならびに捕虫運動の制御機構の化学的解明 (2013)
  • Author(s): 上田 実
  • Organizer: 第48回植物化学調節学会大会
  • Place of Presentation: 新潟大学
  • Invited
• [Presentation] "Glycosylation Switching":生物に学ぶ新しい化学的活性制御 (2013)
  • Author(s): 上田 実
  • Organizer: 第24回万有仙台シンポジウム
  • Place of Presentation: 仙台国際センター
  • Invited
• [Presentation] "Glycosylation Switching" : Glycosylation regulates mode-of-action of bioactive natural products (2012)
  • Author(s): 上田実
  • Organizer: 3rd International Symposium on Creation of Functional Materials-Life Science and Materials-
  • Place of Presentation: 筑波
  • Year and Date: 2012-12-11
  • Invited
• [Presentation] 配糖体型天然物リガンドのケミカルバイオロジーに見る活性制御の新戦略 (2012)
  • Author(s): 上田実
  • Organizer: 後期(秋期)有機合成化学講習会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-20
  • Invited
• [Presentation] Chemical Biology of Naturally Occurring Glycosides : "Glycosylation Switching" (2012)
  • Author(s): 上田実
  • Organizer: The International Symposium on Chemical Biology of Natural Products
  • Place of Presentation: 京都
  • Year and Date: 2012-10-31
  • Invited
• [Presentation] 配糖体型天然物リガンドのケミカルバイオロジーに見る活性制御の新戦略 (2012)
  • Author(s): 上田実
  • Organizer: 生命医薬情報学連合大会
  • Place of Presentation: 千葉
  • Year and Date: 2012-10-14
  • Invited
• [Presentation] 天然物ケミカルバイオロジー : 配糖体リガンドの新しい機能 (2012)
  • Author(s): 上田実
  • Organizer: 早稲田大学FBT生物学・化学・情報科学融合のための戦略的先進理工学研究基盤の形成
  • Place of Presentation: 東京
  • Year and Date: 2012-09-19
  • Invited
• [Presentation] Chemical Biology of Glycoside Natural ProductsChemical Biology of Glycoside Natural Products (2012)
  • Author(s): 上田実
  • Organizer: The Second Asian Chemical Biology Conference (ACBC2)
  • Place of Presentation: 沖縄
  • Year and Date: 2012-07-08
  • Invited
• [Presentation] 天然物ケミカルバイオロジー : 生物現象と天然物リガンド (2012)
  • Author(s): 上田実
  • Organizer: 名古屋大学IGER グリーン自然科学レクチャー
  • Place of Presentation: 名古屋
  • Year and Date: 2012-06-12
• [Presentation] 配糖体型天然物リガンドのケミカルバイオロジー 日本化学会第92 春季年会 (2012)
  • Author(s): 上田実
  • Organizer: 特別企画「天然物ケミカルバイオロジー」
  • Place of Presentation: 慶応義塾大学 横浜
  • Year and Date: 2012-03-25
• [Presentation] 眠る植物と食虫植物の科学‐不思議な生物現象の化学 (2012)
  • Author(s): 上田実
  • Organizer: 日本化学会市民公開講座
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-25
• [Presentation] 配糖体型天然物リガンドのケミカルバイオロジー (2012)
  • Author(s): 上田実
  • Organizer: 日本化学会第92春季年会特別企画「天然物ケミカルバイオロジー」
  • Place of Presentation: 慶応義塾大学日吉キャンパス第4独立館
  • Year and Date: 2012-03-25
• [Presentation] 眠る植物と食虫植物の科学-不思議な生物現象の化学 (2012)
  • Author(s): 上田実
  • Organizer: 日本化学会市民公開講座
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-25
• [Presentation] 配糖体型天然物リガンドのケミカルバイオロジーに見る活性制御の新戦略 (2012)
  • Author(s): 上田 実
  • Organizer: 後期（秋期）有機合成化学講習会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 天然物ケミカルバイオロジー：配糖体リガンドの新しい機能 (2012)
  • Author(s): 上田 実
  • Organizer: 早稲田大学FBT生物学・化学・情報科学融合のための戦略的先進理工学研究基盤の形成
  • Place of Presentation: 東京
  • Invited
• [Presentation] 天然物ケミカルバイオロジー：生物現象と天然物リガンド (2012)
  • Author(s): 上田 実
  • Organizer: 名古屋大学IGERグリーン自然科学レクチャー
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] “Glycosylation Switching”: Glycosylation regulates mode-of-action of bioactive natural products (2012)
  • Author(s): 上田 実
  • Organizer: 3rd International Symposium on Creation of Functional Materials-Life Science and Materials-
  • Place of Presentation: 筑波
  • Invited
• [Presentation] Chemical Biology of Naturally Occurring Glycosides: "Glycosylation Switching" (2012)
  • Author(s): 上田 実
  • Organizer: The International Symposium on Chemical Biology of Natural Products
  • Place of Presentation: 京都
  • Invited
• [Presentation] Chemical Biology of Glycoside Natural Products (2012)
  • Author(s): 上田 実
  • Organizer: Chemical Biology of Glycoside Natural Products, The Second Asian Chemical Biology Conference (ACBC2)
  • Place of Presentation: 沖縄
  • Invited
• [Book] Plant Electrophysiology Signaling and Responses (2012)
  • Author(s): Y. Ishimaru, S. Hamamoto, N. Uozumi, and M.Ueda A. Volkov eds
  • Publisher: Springer-Verlag
• [Book] A. Volkov eds. “Plant Electrophysiology Signaling and Responses” (2012)
  • Author(s): Y. Ishimaru, S. Hamamoto, N. Uozumi, and M. Ueda
  • Publisher: Springer-Verlag