Search for Natural Product based Active Compounds for Neural Stem Cells Modulators
| Project/Area Number |
23310149
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Chiba University |
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Principal Investigator |
ARAI Midori 千葉大学, 薬学研究科(研究院), 准教授 (40373261)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Masami 千葉大学, 大学院・薬学研究院, 教授 (90212927)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 天然物化学 / 神経幹細胞 / 転写因子 / Hes1 / Ngn2 / Wnt / 天然物 / ケミカルバイオロジー / コンビナトリアルケミストリー / 有機合成化学 / bHLH転写因子 |
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| Research Abstract |
Search for neural stem cells modulators has been done by using original cell- and protein-based assays. Transcriptional factors which act in neural stem cells were focused. Several active natural products and synthetic natural product-like compounds were found to accelerate the differentiation of neural stem cells.
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Report
(4 results)
Research Products
(161 results)
