| Project/Area Number |
23310150
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
TANAKA Hiroshi 東京工業大学, 理工学研究科, 准教授 (40334544)
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| Co-Investigator(Renkei-kenkyūsha) |
JINMO Mitsuru 北里大学, 海洋生命学部, 准教授 (10291650)
YAMAGUCHI Yoshiki 理化学研究所, システム糖鎖生物学研究グループ, チームリーダー (90323451)
KAWAUCHI Susumu 東京工業大学, 大学院・理工学研究科, 准教授 (80204676)
ADACHI Yoshiyuki 東京薬科大学, 薬学部, 准教授 (60222634)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 自然免疫 / 真菌 / グリコシル化 / サンゴ / ケミカルバイオロジー / 複合糖質 / 立体選択的 / 構造活性相関 / 糖鎖 / 糖脂質 / リン酸ジエステル / イミダート糖 / 共生 / ジオール / 免疫 / STD-NMR / βグルカン / ケミカルプローブ / グリコシル化反応 / 固相合成 / ワンポット合成 / SLL2 / さんご / 脱保護 |
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| Research Abstract |
The synthesis of biologically active oligosaccharides in symbiosis and immunity and their applications to chemical biological research are described. Forssmann pentasaccharide identified as a ligand of the lectin SLL-2 isolated from an octocoral Sinularia lochmodes, be-ta glucan oligosaccharide stimulating innate immunity and lipomannan glycoconjugates isolated from BCG were selected as target natural glycoconjudates. We prepared by these complex oligosaccharides and related derivatives and elucidation of the structure activity relationships using the synthetic glucans.
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