| Project/Area Number |
23340180
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plasma science
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| Research Institution | Tokyo City University |
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Principal Investigator |
MORI Akira 東京都市大学, 工学部, 教授 (60219996)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Takamichi 東京都市大学, 工学部, 教授 (80260420)
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| Co-Investigator(Renkei-kenkyūsha) |
KUDO Yoshiki 広島大学, 医学部, 教授 (80241082)
IWASHITA Mitsutoshi 杏林大学, 医学部, 教授 (30124936)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | プラズマ吸入 / ﾌﾟﾗｽﾞﾏ医学 / 重症呼吸障害 / 低酸素性虚血性脳症 / 再生医療 / プラズマ医学 |
|---|
| Research Abstract |
We carried out the experiments about the direct inhalationto animal model (pulmonary hypertension of goat or mini-pig and neonatal hypoxia/ischemia rat). The use of inhalated plasma, generated by the atmospheric-pressure plasmas reactor, resulted in increased saturation pulse oxygen in the pulmonary hypertension of animals. Additionally, the blood pressure decreased during plasma inhalation. Nitric oxide (NO) concentrations in the arteries increased after 20 seconds of plasma inhalation, reaching a maximum value at about 160 s and gradually decreased. The NO generated by this device was highly concentrated, reaching a maximum of approximately 10nmol. Moreover, the infarct areas treated with plasma inhalation (15days, 90sec inhalation/ day) were evaluated in the neonatal hypoxic/ischemic rat model. Each plasma inhalation-treated group (n=6) demonstrated significant increae of new bood vessels compared with the no treated group (n=6).
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