A living body action and the application to medical treatment by inhalation of atmospheric pressure plasma flow
| Project/Area Number |
23340180
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plasma science
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| Research Institution | Tokyo City University |
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Principal Investigator |
MORI Akira 東京都市大学, 工学部, 教授 (60219996)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Takamichi 東京都市大学, 工学部, 教授 (80260420)
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| Co-Investigator(Renkei-kenkyūsha) |
KUDO Yoshiki 広島大学, 医学部, 教授 (80241082)
IWASHITA Mitsutoshi 杏林大学, 医学部, 教授 (30124936)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | プラズマ吸入 / ﾌﾟﾗｽﾞﾏ医学 / 重症呼吸障害 / 低酸素性虚血性脳症 / 再生医療 / プラズマ医学 |
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| Research Abstract |
We carried out the experiments about the direct inhalationto animal model (pulmonary hypertension of goat or mini-pig and neonatal hypoxia/ischemia rat). The use of inhalated plasma, generated by the atmospheric-pressure plasmas reactor, resulted in increased saturation pulse oxygen in the pulmonary hypertension of animals. Additionally, the blood pressure decreased during plasma inhalation. Nitric oxide (NO) concentrations in the arteries increased after 20 seconds of plasma inhalation, reaching a maximum value at about 160 s and gradually decreased. The NO generated by this device was highly concentrated, reaching a maximum of approximately 10nmol. Moreover, the infarct areas treated with plasma inhalation (15days, 90sec inhalation/ day) were evaluated in the neonatal hypoxic/ischemic rat model. Each plasma inhalation-treated group (n=6) demonstrated significant increae of new bood vessels compared with the no treated group (n=6).
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] The effect of plasma inhalation for the cardiovascular system by rat2013
Author(s)
S. Murata, A. Mori, M. Watada, T Hirata, C. Tsutsui, T. A. Kondo, G Takahashi
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Journal Title
S. Murata, A. Mori, M. Watada, T Hirata, C. Tsutsui, T. A. Kondo, G Takahashi
Volume: Vol. 21
Pages: 260-265
NAID
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[Presentation] マイクロスポットプラズマ源による血管新生促進メカニズム2011
Author(s)
筒井千尋, 平田孝道, 秋谷昌宏, 田口亮, 平田孝道, 横井由貴子, 小町俊文, 岸本拓巳, 村田茂, 森晃, 秋谷昌宏, 田口亮, 山本俊昭
Organizer
静電気学会
Place of Presentation
東京理科大学
Year and Date
2011-09-13
Related Report
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[Presentation] 大気圧放電プラズマ(Atmospheric Pressure Discharge Plasmas)による虚血後血管新生-低酸素脳症ラットモデルを用いた吸入治療の試み-2011
Author(s)
近藤朱音, 蘇原映碩, 菅野秀俊, 石井博樹, 佐藤茂, 高橋千果, 松本直, 石本人士, 和泉俊一郎, 三上幹男, 森晃
Organizer
日本産科婦人科学会
Place of Presentation
大阪国際会議場
Year and Date
2011-08-29
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