Design of High Performance Catalysts Based on Biomimetic Approach
| Project/Area Number |
23350039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Okayama University (2012-2013)
Nagoya University (2011) |
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Principal Investigator |
SAKAKURA Akira 岡山大学, 自然科学研究科, 教授 (80334043)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 触媒設計・反応 / 合成化学 / 有機化学 / 触媒 / 不斉合成 / バイオミメティック / 酸・塩基 / ブレンステッド酸 |
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| Research Abstract |
Based on acid-base combination chemistry, we conducted the rational design of high performance catalysts with functionalities such as weak secondary interaction and acid-base dual activation. Using these catalysts, we developed highly selective synthetic processes. For example, we achieved dehydrative ester condensation in water using organoammonium catalysts, enantioselective carbon-carbon bond forming reactions (Diels-Alder reaction, polyene cyclization and iodolactonization of unsaturated carboxylic acids) and acylation reaction based on acid-base combination catalysis (cyanoethoxycarbonylation of isatins and dehydrative amide condensation of alpha-hydroxy carboxylic acids).
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Report
(4 results)
Research Products
(107 results)
