| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Research Abstract |
Based on acid-base combination chemistry, we conducted the rational design of high performance catalysts with functionalities such as weak secondary interaction and acid-base dual activation. Using these catalysts, we developed highly selective synthetic processes. For example, we achieved dehydrative ester condensation in water using organoammonium catalysts, enantioselective carbon-carbon bond forming reactions (Diels-Alder reaction, polyene cyclization and iodolactonization of unsaturated carboxylic acids) and acylation reaction based on acid-base combination catalysis (cyanoethoxycarbonylation of isatins and dehydrative amide condensation of alpha-hydroxy carboxylic acids).
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