Precise Characterization of Macromolecular Assemblies for Quality Control of Biomaterials
| Project/Area Number |
23350055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
SATO Takahiro 大阪大学, 理学(系)研究科(研究院), 教授 (10196248)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIDZUME Akihito 大阪大学, 大学院・理学研究科, 准教授 (70294147)
TERAO Ken 大阪大学, 大学院・理学研究科, 講師 (60334132)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 自己組織化高分子 / 感熱応答性高分子 / ポリイオンコンプレックス / ブロック共重合体 / ミセル / 相分離 / 光散乱 / 両親媒性高分子 / 高分子ミセル / 光分散 / 熱変性DNA |
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| Research Abstract |
Macromolecular assemblies are utilized as biomaterials like drug delivery system, nano-carrier, or bio-sensor. Precise characterization of macromolecular assemblies is essential to control the quality of those biomaterials. In this study, we have established the method for characterizing assemblies of thermoresponsive block copolymers and polyelectrolyte complexes in solution. Simultaneous micellization and phase separation took place in three thermoresponsive block copolymers investigated, all of which were weakly segregated and weakly amphiphilic block copolymers. Both micelles and concentrated-phase droplets in the solutions were characterized by small-angle X-ray scattering. The number of net charges and total charges (or the aggregation number) per the polyelectrolyte complex were determined by static and electrophoretic light scattering methods for four combinations of two polyanions and two polycations in aqueous solution to compare with proposed complex formation mechanism.
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Report
(4 results)
Research Products
(105 results)
