| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
Caged compounds which control various functions of living cells by light irradiation have been synthesized and their photochemical cleavage reactions have been studied. Various kinds of pigments and aromatic systems were used for the light absorption part, and these parts and the electron accepting part were connected with the methylene chain. Furthermore, bioactive glutamic acid or acetic acid group was introduced at the electron accepting pyridinium moiety. As a result, release of acetic acid took place via electron transfer reaction from the aromatic dyes to the pyridinium part followed by cleavage reaction with light irradiation. In this case the quantum yield for this reaction attained very high value in the presence of sacrificial donors.
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