| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Highly diastereoselective photochromic diarylethene derivative was achieved based on the intramolecular hydrogen bonds. Its cyclization quantum yield was as high as 0.85 and the diasteremer ratio was >99.5:<0.5, namely nearly perfect stereocontrol was achieved. In this system intramolecular hydrogen bonds worked co-operatively so that both cyclization quantum yield and the cyclization diastereoselectivity became high.
In addition, we carried out photocyclization of a diarylethene possessing hydroxymethyl groups trapped in human serum albumin in phosphate buffer media. When the incubation temperature was kept as -4 degrees centigrade, the enantioselectivity was as high as 71% ee.
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