• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Measurement and Analysis of Bound Water Dynamics in Lyoprotective agents for Preserving Desiccated Biomaterials at Room Temperature

Research Project

Project/Area Number 23360094
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thermal engineering
Research InstitutionThe University of Tokyo

Principal Investigator

SHIRAKASHI Ryo  東京大学, 生産技術研究所, 教授 (80292754)

Co-Investigator(Renkei-kenkyūsha) KIYOSHI Takano  東京大学, 生産技術研究所, 助教 (60302626)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords結合水 / 誘電分光 / 耐乾燥保護物質 / ガラス化 / 水分活性 / 不凍水 / 常温乾燥 / 保護物質
Research Abstract

Biomolecules, cells and other biomaterials, such as scaffold, are widely used in clinical biopsy and tissue engineering. The quality of these biomaterials is of importance because they degrade very rapidly. Recent report suggests that some protective agents have a large potential of adding desiccation tolerance to these biospecies even at the room temperature. In this study, the characteristics of several protective agents that are associated with lyoprotective ability have been measured. These characteristics include the relaxation time of bound water, water activity and glass transition temperature. In addition, the desiccation tolerance of protein and phospholipid with the several protective agents has been evaluated to find out the essential characteristics for better lyoprotective ability.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (20 results)

All 2014 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 3 results) Presentation (7 results) (of which Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 細胞・生体分子の保存操作における物理・化学的環境変化とその影響について2013

    • Author(s)
      白樫 了
    • Journal Title

      臨床病理

      Volume: vol.61補冊 Pages: 108-108

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Dielectric spectroscopy of thin surface layer by Differential Time Domain Reflectometry using a Coplaner Waveguide Circuit line probe2013

    • Author(s)
      Ryo Shirakashi, Tsuyoshi Ogawa, Jun Yamada
    • Journal Title

      Measurement Science and Technology

      Volume: vol.24,No.2 Issue: 2 Pages: 25501-10

    • DOI

      10.1088/0957-0233/24/2/025501

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高周波帯域の誘電分光による角質層内の自由水量の測定2012

    • Author(s)
      白樫 了,細沼賢太,山田 純
    • Journal Title

      第33回熱物性シンポジウム講演論文集

      Pages: 242-244

    • Related Report
      2013 Final Research Report
  • [Journal Article] LEA ペプチドによる巨大リポソームの乾燥保存の試みと分子メカニズムの考察2012

    • Author(s)
      渡辺貴大, 古 隆生, 櫻井 実, 白樫 了
    • Journal Title

      低温生物工学会誌

      Volume: vol.58No.2 Pages: 165-168

    • NAID

      110009612931

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高分子添加が生体の耐凍結・乾燥保護を目的としたトレハロース水溶液の特性に与える影響2012

    • Author(s)
      岡 理一郎,白樫 了
    • Journal Title

      第24 回バイオエンジニアリング講演会講演論文集

      Volume: (CD-ROM)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 高周波帯域の誘電分光による角質層内の自由水量の測定2012

    • Author(s)
      白樫 了,細沼賢太,山田 純
    • Journal Title

      第33回熱物性シンポジウム講演論文集

      Volume: 1 Pages: 242-244

    • Related Report
      2012 Annual Research Report
  • [Journal Article] LEAペプチドによる巨大リポソームの乾燥保存の試みと分子メカニズムの考察2012

    • Author(s)
      渡辺貴大,古木隆生,櫻井 実,白樫 了
    • Journal Title

      低温生物工学会誌

      Volume: Vol.58 No.2 Pages: 165-168

    • NAID

      110009612931

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高分子添加が生体の耐凍結・乾燥保護を目的としたトレハロース水溶液の特性に与える影響2012

    • Author(s)
      岡 理一郎,白樫 了
    • Journal Title

      第24回バイオエンジニアリング講演会(CD-ROM)

      Volume: 1

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 生体内結合水の緩和時間分布の測定2011

    • Author(s)
      白樫 了, 鈴木順也, 山田 純
    • Journal Title

      第32回熱物性シンポジウム講演論文集

      Pages: 533-535

    • Related Report
      2013 Final Research Report
  • [Journal Article] 生体内結合水の緩和時間分布の測定2011

    • Author(s)
      白樫 了,鈴木順也,山田 純
    • Journal Title

      第32回熱物性シンポジウム講演論文集

      Volume: 1 Pages: 533-535

    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞・生体分子の保存操作における物理・化学的環境変化とその影響について2013

    • Author(s)
      白樫 了
    • Organizer
      日本臨床検査医学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2013-11-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 高周波帯域の誘電分光による角質層内の自由水量の測定2012

    • Author(s)
      白樫 了
    • Organizer
      第33回熱物性シンポジウム
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2012-10-04
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] LEAペプチドによる巨大リポソームの乾燥保存の試みと分子メカニズムの考察2012

    • Author(s)
      渡辺貴大
    • Organizer
      第57回低温生物工学会年会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高分子添加が生体の耐凍結・乾燥保護を目的としたトレハロース水溶液の特性に与える影響2012

    • Author(s)
      岡理一郎
    • Organizer
      日本機械学会第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体内の結合水と凍結・乾燥特性2011

    • Author(s)
      白樫 了
    • Organizer
      低温生物工学会セミナー
    • Place of Presentation
      いわて県民情報交流センター
    • Year and Date
      2011-07-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体内の結合水の測定と凍結・乾燥特性2011

    • Author(s)
      白樫 了
    • Organizer
      低温生物工学会セミナー
    • Place of Presentation
      いわて県民情報交流センター
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 生体内結合水の緩和時間分布の測定2011

    • Author(s)
      白樫 了,鈴木順也,山田 純
    • Organizer
      第32回熱物性シンポジウム講演論文集, (2011)
    • Place of Presentation
      慶應義塾大学 日吉キャンパス「来往舎」・「協生館」
    • Related Report
      2011 Annual Research Report
  • [Book] ナノ・マイクロスケール熱物性ハンドブック__分担 4.122014

    • Author(s)
      白樫 了
    • Publisher
      養賢堂
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞の乾燥保護剤2012

    • Inventor(s)
      櫻井 実, 古木隆生, 渡辺貴大, 白樫 了
    • Industrial Property Rights Holder
      東京工業大学, 東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-05-23
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞の乾燥保護剤2012

    • Inventor(s)
      櫻井 実,古木隆生,渡部貴大,白樫 了
    • Industrial Property Rights Holder
      東京工業大学,東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-05-23
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi