| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Research Abstract |
We characterized the membrane phase separation structures in oxidized cholesterol(Chol)-containing systems. 7-kotocholesterol(7-keto) and 7beta-hydoroxycholesterol(7beta).
Especially, the phase separation was strongly enhanced in Chol/7keto system. On the other hand, the phase separation was suppressed in 7beta-containing system. Our results showed that the hydrophilic interactions among lipids and cholesterols play important roles in formation and stability of domain structures.
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