| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
This study aimed development of chemical protein cationization techniques for cancer antigens. Since most of cancer antigen proteins are flexible and unstable, solubilization with protein cationization techniques were useful methodology to prepare water-soluble and full-length cancer antigens. Using these cationized antigens, antigen antibodies for cancer antigens raised in cancer patients were successfully detected with a highly sensitive assay. Combining these developed techniques and enhanced cancer antigen production resource, we have successfully developed tools for cancer immunotherapy.
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