| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Research Abstract |
Therapeutic antibody is workhorse for the development of pharmaceutical industries. In Japan, more than quarter of biopharmaceuticals was produced using CHO cell line. Recently, over 10 g/L antibody production was reported using CHO cell line. In this project, we focused on the cellular quality-control system for protein secretion process in CHO cell. On the basis of quality-control mechanism, we constructed the improved protein production system.
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