| Project/Area Number |
23360374
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
NAKAYAMA Yasuhide 独立行政法人国立循環器病研究センター, 研究所, 室長 (50250262)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEWA Yoshiaki 独立行政法人国立循環器病研究センター, 研究所, 室長 (20332405)
UECHI Masami 日本大学, 生物資源科学部, 教授 (90296426)
KANDA Keiichi 京都府立医科大学, 医学研究科, 講師 (60295649)
WATANABE Taiji 京都府立医科大学, 医学研究科, 助教 (20448723)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 再生医療 / 生体内組織形成 / バイオリアクター / バイオプロセス / バイオバルブ / バイオチューブ / セルフリーデバイス / 体内組織工学 / 生体内組織工学 / 組織工学 / 体内バイオプロセス / 血管 / 心臓弁 |
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| Research Abstract |
Tissue-engineering techniques may play a prominent role in the future development of cardiovascular replacements. Research designed to create in vitro tissue-engineered tissues has focused on the scaffold materials, culturing of cells, and its condition. As a feasible, regenerative medicine approach, this study developed cell-free devices for the preparation of completely autologous in vivo tissue-engineered cardiovascular tissues without any artificial scaffolds by using of in-body tissue architecture technology. The tissue formation process was enhanced successfully by design or photo engineering approaches. The biocompatibility was obtained by material engineering approach. We used a 3D printer to produce cell-free devices. The clinical feasibility of the valve-shaped tissues obtained from the devices was evaluated by their implanting in goats after evaluating their function and durability in vitro.
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