Genetic analyses of the molecular and neuronal mechanisms for the regulation of forgetting
| Project/Area Number |
23370002
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Kyushu University |
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Principal Investigator |
ISHIHARA Takeshi 九州大学, 理学(系)研究科(研究院), 教授 (10249948)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Manabi 九州大学, 理学研究院, 助教 (70359933)
SAWATARI Etsuko 九州大学, 基幹教育院, 助教 (60456605)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 行動遺伝 / 線虫 / 記憶 / カルシウムイメージング / 神経科学 / 学習 / 遺伝学 |
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| Research Abstract |
Animals show a variety of behavioral plasticity, in which animals change their behavior dependent on their environments. Those behavioral plasticity must be sustained for an appropriate time to survive. However, the neuronal and molecular mechanisms of forgetting of memories are poorly understood. Therefore, we studied on the forgetting of olfactory adaptation in C. elegans as a model for the behavioral plasticity. We found that the forgetting of the olfactory adaptation is actively regulated by the environmental conditions before and after conditioning. In addition, we identified a pair of neurons that secrete signals for the forgetting of the olfactory adaption in other sensory neurons. These results suggested that the forgetting is actively regulated by the neuronal communications.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] An expanded palette of genetically encoded Ca2+ indicators2011
Author(s)
Zhao YG, Araki S, Wu JH, Teramoto T, Chang YF, Nakano M, Abdelfattah AS, Fujiwara M, Ishihara T, Nagai T, Campbell R
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Journal Title
Science
Volume: 333
Issue: 6051
Pages: 1888-1891
DOI
Related Report
Peer Reviewed
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