The molecular mechanisms of heterochromatin establishment and maintenance
| Project/Area Number |
23370004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Nagoya City University (2012-2013)
The Institute of Physical and Chemical Research (2011) |
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Principal Investigator |
NAKAYAMA Jun-ichi 名古屋市立大学, システム自然科学研究科, 准教授 (60373338)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Aki 独立行政法人理化学研究所, クロマチン動態研究チーム, 研究員 (80399534)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 遺伝子 / 発現制御 / ヘテロクロマチン / RNA干渉 / 分裂酵母 / RNAi / ユビキチン化 |
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| Research Abstract |
In this research program, we tried to gain a better understanding of the molecular mechanisms underlying the establishment and maintenance of higher-order chromatin structure, heterochromatin. Using fission yeast as a model organism, we employed a genetic screening and successfully identified two novel RNAi factors, Ers1 and Dsh1, involved in heterochromatin assembly. Further analyses uncovered that these factors play roles in recruiting RNAi-effector complexes, such as RDRC, and promote siRNA production to form higher-order chromatin structure.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly2012
Author(s)
Hayashi, A., Ishida, M., Kawaguchi, R., Urano, T., Murakami, Y., Nakayama, J-I.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: (印刷中)
Issue: 16
Pages: 6159-64
DOI
Related Report
Peer Reviewed
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[Journal Article] Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex2011
Author(s)
Hatanaka A, Chen B, Sun JQ, Mano Y, Funakoshi M, Kobayashi H, Ju Y, Mizutani T, Shinmyozu K, Nakayama J, Miyamoto K, Uchida H, & Oki M
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Journal Title
Genes Genet Syst
Volume: 86
Pages: 305-314
NAID
URL
Related Report
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[Journal Article] Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex2011
Author(s)
Hatanaka A, Chen B, Sun J-Q, Mano Y, Funakoshi M, Kobayashi H, Ju Y, Mizutani T, Shimyozu K, Nakayama J, Miyamoto K, Uchida H, Oki M
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Journal Title
Genes & Genetic Systems
Volume: 86
Issue: 5
Pages: 305-314
DOI
NAID
ISSN
1341-7568, 1880-5779
Related Report
Peer Reviewed
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