| Project/Area Number |
23370054
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Hiromi 香川大学, 総合生命科学研究センター, 准教授 (10313305)
NISHI Nozumu 香川大学, 総合生命科学研究センター, 准教授 (10145047)
NAKAKITA Shinichi 香川大学, 総合生命科学研究センター, 准教授 (40314356)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYATA Shigeru 中部大学, 応用生物学部, 准教授 (90314913)
HOJO Hironobu 大阪大学, 蛋白質研究所, 教授 (00209214)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | X線結晶解析 / 糖鎖 / 糖鎖結合タンパク質 / ガレクチン / ヘマグルチニン / エンドライシン / ウェルシュ菌 / ボツリヌス菌 / ペプチドグリカン / Ｘ線結晶解析 / 糖鎖プロセッシング酵素 / グリコシド結合 |
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| Research Abstract |
Cell surface oligosaccharides are involved in immune responses and bacterial/viral infections, and they are specifically recognized by carbohydrate-binding proteins. X-ray structures of the complexes of carbohydrate-binding proteins with the target oligosaccharides have been determined to elucidate the carbohydrate recognition mechanisms. The results of this research project give new insights into the carbohydrate recognition mechanisms of galectin-8, a hemagglutinin subcomponent of the botulinum neurotoxin, and an endolysin encoded by episomal phage of Clostridium perfringens.
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