An acquired immune system involved in the tissue remodeling through self antigens
| Project/Area Number |
23370059
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Niigata University |
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Principal Investigator |
IZUTSU YUMI 新潟大学, 自然科学系, 准教授 (20301921)
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| Co-Investigator(Kenkyū-buntansha) |
IWABUCHI Kazuya 北里大学, 医学部, 教授 (20184898)
ITO Michihiko 北里大学, 理学部, 准教授 (90240994)
OKA Atsuko 日本医科大学, 医学部, 教授 (50175254)
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| Co-Investigator(Renkei-kenkyūsha) |
MAENO Mitsugu 新潟大学, 自然科学系, 教授 (10190315)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | タンパク質 / 発現制御 / 発生・分化 / 細胞・組織 / 免疫学 / 両生類 / アポトーシス / T細胞 / アフリカツメガエル / 両生類の変態 / 幼生抗原 / 免疫 / 細胞死 / 皮膚 / 抗原 |
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| Outline of Final Research Achievements |
Vertebrate ontogenesis, including Xenopus frogs, shows morphological changes from embryonic- (larval-) organs into the adult counterparts. This process is called tissue remodeling. The most drastic remodeling is seen in the tadpole tail regression during amphibian metamorphosis. We have previously proposed a new model that the adult-type immune cells, which are newly differentiated during metamorphosis, recognize and remove own tail tissues as non-self. We have isolated two genes encoding the antigen proteins, Ouro1 and Ouro2, as targets for adult immune T cells. In this study, to clarify function of T cells vs these Ouro1 and Ouro2 antigens, we analyzed gain- and loss-of function of T cells. Results suggest that T cells are nessesorry and sufficient for the regression of tadpole tails expressing both Ouro1 and Ouro2 antigen proteins.
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Report
(5 results)
Research Products
(21 results)
