The integrative research for regulation by protein tyrosine phosphatases of biological functions and its molecular mechanism

• Project/Area Number: 23370061
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Kobe University
• Principal Investigator: MATOZAKI Takashi 神戸大学, 医学(系)研究科(研究院), 教授 (80252782)
• Co-Investigator(Kenkyū-buntansha): OHNISHI Hiroshi 群馬大学, 保健学研究科, 教授 (70334125)
• Co-Investigator(Renkei-kenkyūsha): MURATA Yoji 神戸大学, 医学研究科, 准教授 (60400735)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000); Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2011: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: シグナル伝達 / 生体分子 / 蛋白質 / 脳・神経 / 免疫学

Research Abstract

We have here performed the integrative research for the biological functions and molecular mechanisms for the protein tyrosine phosphatases SHP-2 as well as the related signaling pathway CD47-SIRPalpha, and R3-receptor type PTPs. We have shown that SHP-2 in the post-mitotic neurons is important for regulation of the neuronal activity. The CD47-SIRPalpha is important for regulation of dendritic cells as well as organization of lymphoid tissues. In addition, VE-PTP is implicated in regulation of endothelial cell functions by shear stress.

Research Products

• [Journal Article] Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium (2014)
  • Author(s): Yamashita H, Kotani T, Park JH, Murata Y, Okazawa H, Ohnishi H, Ku Y, Matozaki T
  • Journal Title: PLoSOne Volume: 9 Issue: 3 Pages: e92904-e92904
  • DOI: 10.1371/journal.pone.0092904
  • Peer Reviewed
• [Journal Article] The CD47-SIRPα signalling system : its physiological roles and therapeutic application (2014)
  • Author(s): Murata Y, Kotani T, Ohnishi H, Matozaki T
  • Journal Title: J Biochem Volume: 155 Issue: 6 Pages: 335-344
  • DOI: 10.1093/jb/mvu017
  • NAID: 40020088978
  • Peer Reviewed
• [Journal Article] Comprehensive behavioral analysis of cluster of differentiation 47 knockout mice (2014)
  • Author(s): Koshimizu H, Takao K, Matozaki T, Ohnishi H, Miyakawa T
  • Journal Title: PLoSOne Volume: 9 Issue: 2 Pages: e89584-e89584
  • DOI: 10.1371/journal.pone.0089584
  • Peer Reviewed / Open Access
• [Journal Article] Signal Regulatory Protein Alpha Is Present in Several Neutrophil Granule Populations and Is Rapidly Mobilized to the Cell Surface to Negatively Fine-Tune Neutrophil Accumulation in Inflammation (2014)
  • Author(s): Stenberg A, Karlsson A, Feuk-Lagerstedt E, Christenson K, Bylund J, Oldenborg A, Vesterlund L, Matozaki T, Sehlin J, Oldenborg PA
  • Journal Title: J Innate Immun Volume: 6 Issue: 4 Pages: 553-560
  • DOI: 10.1159/000357820
  • Peer Reviewed
• [Journal Article] Shear Stress-induced Redistribution of Vascular Endothelial-Protein-tyrosine Phosphatase (VE-PTP) in Endothelial Cells and Its Role in Cell Elongation (2014)
  • Author(s): Mantilidewi KI, Murata Y, Mori M, Otsubo C, Kotani T, Kusakari S, Ohnishi H, Matozaki T
  • Journal Title: J Biol Chem Volume: 289 Issue: 10 Pages: 6451-61
  • DOI: 10.1074/jbc.m113.529503
  • Peer Reviewed
• [Journal Article] The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment. (2014)
  • Author(s): Iwamoto C
  • Journal Title: Exp Hematol Volume: 42 Issue: 3 Pages: 163-171
  • DOI: 10.1016/j.exphem.2013.11.005
  • Peer Reviewed
• [Journal Article] Autoimmune animal models in the analysis of the CD47-SIRPα signaling pathway (2014)
  • Author(s): Murata Y, Saito Y, Kaneko T, Kotani T, Kaneko Y, Ohnishi H, Matozaki T
  • Journal Title: Methods Volume: 65 Issue: 2 Pages: 254-9
  • DOI: 10.1016/j.ymeth.2013.09.016
  • Peer Reviewed
• [Journal Article] Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state (2013)
  • Author(s): Zen K, Guo Y, Bian Z, Lv Z, Zhu D, Ohnishi H, Matozaki T, Liu Y
  • Journal Title: Nat Commun Volume: 4 Issue: 1 Pages: 2436-2436
  • DOI: 10.1038/ncomms3436
  • Peer Reviewed
• [Journal Article] Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling (2013)
  • Author(s): Koskinen C, Persson E, Baldock P, Stenberg Å, Boström I, Matozaki T, Oldenborg PA, Lundberg P
  • Journal Title: J Biol Chem Volume: 288 Issue: 41 Pages: 29333-44
  • DOI: 10.1074/jbc.m113.494591
  • Peer Reviewed
• [Journal Article] SIRPα signaling regulates podocyte structure and function (2013)
  • Author(s): Takahashi S, Tomioka M, Hiromura K, Sakairi T, Hamatani H, Watanabe M, Ikeuchi H, Kaneko Y, Maeshima A, Aoki T, Ohnishi H, Matozaki T, Nojima Y
  • Journal Title: Am J Physiol Renal Physiol Volume: 305 Issue: 6 Pages: 861-70
  • DOI: 10.1152/ajprenal.00597.2012
  • Peer Reviewed
• [Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. (2013)
  • Author(s): Yamauchi T
  • Journal Title: Blood Volume: 121 Issue: 8 Pages: 1316-1325
  • DOI: 10.1182/blood-2012-06-440354
  • Peer Reviewed
• [Journal Article] Tyrosine phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and its functional roles (2013)
  • Author(s): Daniwijaya EW
  • Journal Title: Kobe Journal of Medical Sciences Volume: 59
  • Peer Reviewed
• [Journal Article] Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus. (2012)
  • Author(s): Hayashi Y
  • Journal Title: Biochemical and biophysical research communications. Volume: 428 Issue: 4 Pages: 475-481
  • DOI: 10.1016/j.bbrc.2012.10.083
  • Peer Reviewed
• [Journal Article] The absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons (2012)
  • Author(s): Marschinke F, Hashemian S, Matozaki T, Oldenborg PA, Strömberg I
  • Journal Title: PLoSOne Volume: 7 Issue: 9 Pages: e45218-e45218
  • DOI: 10.1371/journal.pone.0045218
  • Peer Reviewed
• [Journal Article] SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox) (2012)
  • Author(s): van Beek EM, Zarate JA, van Bruggen R, Schornagel K, Tool AT, Matozaki T, Kraal G, Roos D, van den Berg TK
  • Journal Title: Cell Rep Volume: 2 Issue: 4 Pages: 748-55
  • DOI: 10.1016/j.celrep.2012.08.027
  • Peer Reviewed
• [Journal Article] Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement (2012)
  • Author(s): Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD
  • Journal Title: J Cell Sci Volume: 125 Pages: 5535-45
  • DOI: 10.1242/jcs.111260
  • Peer Reviewed
• [Journal Article] SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress (2012)
  • Author(s): Wang L, Lu Y, Deng S, Zhang Y, Yang L, Guan Y, Matozaki T, Ohnishi H, Jiang H, Li H
  • Journal Title: J Neurochem Volume: 122 Issue: 4 Pages: 834-43
  • DOI: 10.1111/j.1471-4159.2012.07818.x
  • Peer Reviewed
• [Journal Article] Dendritic cell-specific ablation of the protein tyrosine phosphatase shp1 promotes Th1 cell differentiation and induces autoimmunity. (2012)
  • Author(s): Kaneko T., Saito Y., Kotani T., Okazawa H., Iwamura H., Sato-Hashimoto M., Kanazawa Y., Takahashi S., Hiromura K., Kusakari S.Kaneko Y., Murata Y., Ohnishi H., Nojima Y., Takagishi K., and Matozaki T.
  • Journal Title: J. Immunol Volume: 188 Issue: 11 Pages: 5397-5407
  • DOI: 10.4049/jimmunol.1103210
  • Peer Reviewed
• [Journal Article] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain (2012)
  • Author(s): Maruyama T., Kusakari S., Sato-Hashimoto M., Hayashi Y., Kotani T., Murata Y., Okazawa H., Oldenborg P.-A., Kishi S., Matozaki T., and Ohnishi H.
  • Journal Title: J. Neurochem Volume: 121 Issue: 6 Pages: 891-902
  • DOI: 10.1111/j.1471-4159.2012.07748.x
  • Peer Reviewed
• [Journal Article] The Rho kinase pathway regulates the migration of dendritic cells through SIRP-α (2012)
  • Author(s): Ogura K, Fukunaga A, Taguchi K, Nagai H, Yu X, Oniki S, Okazawa H, Matozaki T, Horikawa T, Nishigori C
  • Journal Title: J Dermatol Sci Volume: 66 Issue: 1 Pages: 74-6
  • DOI: 10.1016/j.jdermsci.2012.02.003
  • Peer Reviewed
• [Journal Article] Src family kinases: modulators of neurotransmitter receptor function and behavior. (2011)
  • Author(s): Ohnishi H., Murata Y., Okazawa H., and Matozaki T.
  • Journal Title: Trends Neurosci Volume: 34 Issue: 12 Pages: 629-637
  • DOI: 10.1016/j.tins.2011.09.005
  • Peer Reviewed
• [Journal Article] CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction (2011)
  • Author(s): Zhao XW, van Beek EM, Schornagel K, Van der Maaden H, Van Houdt M, Otten MA, Finetti P, Van Egmond M, Matozaki T, Kraal G, Birnbaum D, van Elsas A, Kuijpers TW, Bertucci F, van den Berg TK
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Issue: 45 Pages: 18342-7
  • DOI: 10.1073/pnas.1106550108
  • Peer Reviewed
• [Journal Article] SIRPα /CD172a regulates eosinophil homeostasis (2011)
  • Author(s): Verjan Garcia N, Umemoto E, Saito Y, Yamasaki M, Hata E, Matozaki T, Murakami M, Jung YJ, Woo SY, Seoh JY, Jang MH, Aozasa K, Miyasaka M
  • Journal Title: J Immunol Volume: 187 Issue: 5 Pages: 2268-77
  • DOI: 10.4049/jimmunol.1101008
  • Peer Reviewed
• [Journal Article] Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen. (2011)
  • Author(s): Sato-Hashimoto M., Saito Y., Ohnishi H., Iwamura H., Kanazawa Y., Kusakari S., Kotani T., Mori M., Murata Y., Okazawa H., Ware CF., Olodenbrg PA., Nojima Y., and Matozaki T.
  • Journal Title: J. Immunol Volume: 187 Issue: 1 Pages: 291-297
  • DOI: 10.4049/jimmunol.1100528
  • Peer Reviewed
• [Journal Article] Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen (2011)
  • Author(s): Sato-Hashimoto M., Matozaki T., et al
  • Journal Title: J.Immunol. Volume: 187 Pages: 291-297
  • Peer Reviewed
• [Journal Article] SIRPα/CD172a regulates eosinophil homeostasis (2011)
  • Author(s): Verjan Garcia N., Matozaki T., Miyasaka M., et al
  • Journal Title: J.Immunol. Volume: 187 Pages: 2268-2277
  • Peer Reviewed
• [Journal Article] CD47-signal regulatory protein-(SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction (2011)
  • Author(s): Zhao X., Matozaki T., van den Berg T.K., et al
  • Journal Title: Proc.Natl.Acad.Sci.USA. Volume: 108 Pages: 18342-18347
  • Peer Reviewed
• [Journal Article] Src family kinases : modulators of neurotransmitter receptor function and behavior (2011)
  • Author(s): Ohnishi, H., Matozaki T., et al
  • Journal Title: Trends Neurosci. Volume: 34(Review) Pages: 629-637
  • Peer Reviewed
• [Presentation] 樹状細胞及び二次リンパ組織の恒常性維持におけるSIRPαの役割 (2014)
  • Author(s): 鷲尾健, 小谷武徳, レスパティカダトゥ, 村田陽二, 岡澤秀樹, 大西浩史, 福永淳, 錦織千佳子, 的崎尚
  • Organizer: 第6回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 三重大学(三重)
  • Year and Date: 2014-02-21
• [Presentation] SIRPα -CD47 system regulates the homeostasis of dendritic cells in lymphoid tissues (2013)
  • Author(s): Washio K, Kotani T, Datu Respatika, Murata Y, Okazawa H, Ohnishi H, Fukunaga A, Nishigori C, Matozaki T
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2013-12-12
• [Presentation] R3受容体型チロシンホスファターゼの発現, 局在と生理機能 (2013)
  • Author(s): 的崎尚, 村田陽二, 小谷武徳, Yana Supriatna, 森宗昌, 岡澤秀樹, 大西浩史
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場ほか(兵庫)
  • Year and Date: 2013-12-05
• [Presentation] Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases (2013)
  • Author(s): Matozaki T
  • Organizer: The 2nd Taiwan-Japan Bilateral Conference on Protein Phosphatases
  • Place of Presentation: 国家衛生研究院(新竹市Hsinchu/TAIWAN)
  • Year and Date: 2013-11-29
• [Presentation] 受容体型チロ シンホス フ ァ タ ーゼ SAP-1によ る 腸管免疫制御/Regulation of intestinal immunity by the protein tyrosine phosphatase SAP-1 (2013)
  • Author(s): 村田陽二, 小谷武徳, Supriatna Yana , 森宗昌, 草苅伸也, 岡澤秀樹, 大西浩史, 的崎尚
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2013-10-03
• [Presentation] Role of VE-PTP in shear stress responses of endothelial cells (2013)
  • Author(s): Mantilidewi KI, Murata Y, Mori M, Kotani T, Kusakari S, Okazawa H, Ohnishi H, Matozaki T
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2013-09-11
• [Presentation] Functional Analysis of A non-receptor type protein tyrosine phosphatase Shp2 in the adult brain Neuro2013 (2013)
  • Author(s): Kusakari S, Saitow F, Sato-Hashimoto M, Shibasaki K, Ago Y, Matsuda T, Benjamin G. Neel, Kotani T, Murata Y, Matozaki T, Ohnishi H
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2013-06-20
• [Presentation] Regulation of intestinal immunity by the protein tyrosine phosphatase SAP-1 (2013)
  • Author(s): Murata Y, Kotani T, Yana Supriatna, Daniwijaya EW, Ohnishi H, Matozaki T
  • Organizer: 第10回プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 国立がん研究センター(東京)
  • Year and Date: 2013-02-08
• [Presentation] The protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM in the intestinal epithelium FASEB (2013)
  • Author(s): Matozaki T, Murata Y, Kotani T, Yana Supriatna, Okazawa H, Ohnishi H
  • Place of Presentation: The Steamboat Grand(SteamboatSprings/USA)
• [Presentation] The protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM in the intestinal epithelium (2013)
  • Author(s): Takashi Matozaki, Yoji Murata, Takenori Kotani, Yana Supriatna, Hideki Okazawa, Hiroshi Ohnishi
  • Organizer: FASEB
  • Place of Presentation: USA・The Steamboat Grand （SteamboatSprings）
• [Presentation] Roles of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium (2013)
  • Author(s): Takenori Kotani, Hironori Yamashita, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Takashi Matozak
  • Organizer: FASEB
  • Place of Presentation: USA・The Steamboat Grand （SteamboatSprings）
• [Presentation] Microbiota modulates the turnover of intestinal epithelial cells (2013)
  • Author(s): Jung-ha Park, Takenori Kotani, Yoji Murata, Takashi Matozaki
  • Organizer: FASEB
  • Place of Presentation: USA・The Steamboat Grand （SteamboatSprings）
• [Presentation] 脾臓T細胞の恒常性調節への SIRPα の関与/Signal regulatory protein alpha regulates the homeostasis of T lymphocytes in the spleen (2012)
  • Author(s): 橋本(佐藤)美穂, 齊藤泰之, 金子哲也, 大西浩史, 草苅伸也, 小谷武徳, 村田陽二, 岡澤秀樹, 的崎尚
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場ほか(福岡)
  • Year and Date: 2012-12-16
• [Presentation] 細胞質型チロシンホスファターゼShp2の成熟脳における機能解析/Functional analysis of tyrosine phosphatase Shp2 in the adult brain (2012)
  • Author(s): 草苅伸也, 橋本美穂, 柴崎貢志, 吾郷由希夫, 松田敏夫, Benjamin G. Neel, 小谷武徳, 村田陽二, 的崎尚, 大西浩史
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場ほか(福岡)
  • Year and Date: 2012-12-16
• [Presentation] Protein tyrosine phosphatases and the CD47-SIRPα System that mediates cell-to-cell communication (2012)
  • Author(s): Matozaki T
  • Organizer: The First Taiwan Phosphatase Conference
  • Place of Presentation: 国立成功大学(Tainan/TAIWAN)
  • Year and Date: 2012-11-10
• [Presentation] R egulation of brain functions by a protein tyrosine phosphatase Shp2 (2012)
  • Author(s): Kusakari S, Hashimoto M, Hayashi Y, Kusakari Y, Ago Y, Matsuda T, Shibasaki K, Kotani T, Murata Y, Benjamin G. Neel, Matozaki T, Ohnishi H
  • Organizer: 平成24年度国際シナプス研究会
  • Place of Presentation: 岡崎コンファレンスセンター(愛知)
  • Year and Date: 2012-11-08
• [Presentation] チロシンホスファターゼの機能と病態 (2012)
  • Author(s): 的崎尚
  • Organizer: 群馬大学・秋田大学連携グローバルCOEプログラム「生体調節シグナルの統合的研究」最終シンポジウム
  • Place of Presentation: 群馬大学アメニティーモール
  • Year and Date: 2012-02-09
• [Presentation] 成熟脳におけるShp2の生理機能解析 (2012)
  • Author(s): 草苅伸也, 小谷武徳, 橋本美穂, 村田陽二, 岡澤秀樹, 吾郷由 紀夫, 松田 敏夫, Benjamin G. Neel, 的崎尚, 大西浩史
  • Organizer: 第5回プロテインホスファターゼ研究会学術集会大阪
  • Place of Presentation: 大阪大学銀杏会館(大阪)
  • Year and Date: 2012-01-19
• [Presentation] 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP-1による腸管免疫制御 (2012)
  • Author(s): 小谷武徳, 村田陽二, Yana Supriatna, 岡澤秀樹, 大西浩史, Edwin Daniwijaya, 草苅伸也, 定方久延, 大川克也, 的崎尚
  • Organizer: 第5回プロテインホスファターゼ研究会学術集会大阪
  • Place of Presentation: 大阪大学銀杏会館(大阪)
  • Year and Date: 2012-01-19
• [Presentation] 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP-1による腸管免疫制御 (2012)
  • Author(s): 小谷武徳、的崎尚, 他
  • Organizer: 第5回プロテインホスファターゼ研究会学術集会大阪
  • Place of Presentation: 大阪大学銀杏会館
  • Year and Date: 2012-01-19
• [Presentation] 成熟脳におけるShp2の生理機能解析 (2012)
  • Author(s): 草苅伸也、的崎尚, 他
  • Organizer: 第5回プロテインホスファターゼ研究会学術集会大阪
  • Place of Presentation: 大阪大学銀杏会館
  • Year and Date: 2012-01-19
• [Presentation] 低温ストレスによる受容体型分子SIRPαのチロシンリン酸化誘導 (2012)
  • Author(s): 草苅伸也
  • Organizer: 第３０回内分泌代謝学サマーセミナー
  • Place of Presentation: 群馬県・伊香保 福一
• [Presentation] 蛋白質チロシンホスファターゼShp2の成熟脳における機能解析 (2011)
  • Author(s): 草苅伸也、的崎尚, 他
  • Organizer: 第2回国際放射線神経生物学会大会
  • Place of Presentation: 群馬大学刀城会館
  • Year and Date: 2011-12-03
• [Presentation] The R3 subtype of receptor-type protein tyrosine phosphatases : Expression, localization, and biological function (2011)
  • Author(s): Matozaki T
  • Organizer: The First Japan-Taiwan Bilateral Conference on Protein Phosphatases
  • Place of Presentation: 基礎生物学研究所(愛知)
  • Year and Date: 2011-12-02
• [Presentation] The R3 subtype of receptor-type protein tyrosine phosphatases : Expression, localization, and biological function (2011)
  • Author(s): Matozaki, T.
  • Organizer: The First Japan-Taiwan Bilateral Conference on Protein Phosphatases
  • Place of Presentation: 基礎生物学研究所
  • Year and Date: 2011-12-02
• [Presentation] Dendritic cell-specific depletion of protein tyrosine phosphatase Shp1 promotes Th1 differentiation causes autoimmunity (2011)
  • Author(s): Kaneko T., Matozaki, T., et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] A new phosphotyrosine signaling pathway related to autoimmune diseases and cancers (2011)
  • Author(s): Matozaki, T.
  • Organizer: 2nd International Joint Symposium Frontier In Biomedical Sciences : From Genes to Applications
  • Place of Presentation: Universitas Gadjah Mada
  • Year and Date: 2011-11-18
• [Presentation] 樹状細胞のチロシンホスファターゼSHP-1は自己免疫疾患発症に関与する (2011)
  • Author(s): 金子哲也、的崎尚, 他
  • Organizer: 第26回日本整形外科学会基礎技術集会
  • Place of Presentation: ベイシア文化ホール
  • Year and Date: 2011-10-21
• [Presentation] チロシンリン酸化シグナルによるうつ様行動の制御/Regulation by protein tyrosine phosphorylation of depression-like behavior (2011)
  • Author(s): 大西浩史, 的崎尚
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-17
• [Presentation] Regulation by protein tyrosine phosphorylation of depression-like behavior (2011)
  • Author(s): 大西浩史、的崎尚, 他
  • Organizer: Neuroscience 2011
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-17
• [Presentation] 血管内皮細胞のシェアストレス刺激応答におけるVE-PTPの機能解析 (2011)
  • Author(s): 村田陽二、的崎尚, 他
  • Organizer: 群馬大学・秋田大学連携グローバルCOEプログラム「生体調節シグナルの統合的研究」第5回グローバルCOE若手研究者シンポジウム
  • Place of Presentation: 秋田キャッスルホテル
  • Year and Date: 2011-08-31
• [Presentation] チロシンホスファターゼSAP-1の機能と病態 (2011)
  • Author(s): 岡澤秀樹、的崎尚, 他
  • Organizer: 第10回生体機能研究会
  • Place of Presentation: 清流の郷ブルーヴィラあなぶき
  • Year and Date: 2011-07-30
• [Presentation] チロシンホスファターゼの機能と病態 (2011)
  • Author(s): 的崎尚
  • Organizer: 日本生化学会東北支部第77回例会・シンポジウム
  • Place of Presentation: 東北大学さくらホール
  • Year and Date: 2011-07-21
• [Presentation] Functional Analysis of A non-receptor type protein tyrosine phosphatase Shp2 in the adult brain
  • Author(s): Shinya Kusakari, Fumihito Saitow, Miho Sato-Hashimoto, Koji Shibasaki, Yukio Agou, Toshio Matsuda, Benjamin G. Neel, Takenori Kotani, Yoji Murata, Takashi Matozaki, Hiroshi Ohnishi
  • Organizer: Neuro 2013
  • Place of Presentation: 京都府・国立京都国際会館
• [Presentation] Hypothermia - dependent and - independent effects of forced swim on the phosphorylation satates of signaling molecules in mouse hippocampus
  • Author(s): Miho Sato-Hashimoto, Yuriko Hayashi, Shinya Kusakari, Eriko Urano, Masahiro Shigeno, Tsuneo Sekijima, Takenori Kotani, Yoji Murata, Hirokazu Murakami, Takashi Matozaki, Hiroshi Ohnishi
  • Organizer: Neuro 2013
  • Place of Presentation: 京都府・国立京都国際会館
• [Presentation] 成熟腸上皮細胞の寿命決定の分子基盤
  • Author(s): 的崎尚、朴貞河、小谷武徳
  • Organizer: 第12回生体機能研究会
  • Place of Presentation: 群馬県・ホテル木暮 (伊香保温泉)
• [Presentation] 腸上皮の恒常性維持におけるチロシンホスファターゼShp2の役割
  • Author(s): 小谷武徳、山下博成、村田陽二、岡澤秀樹、大西浩史、具英成、的崎尚
  • Organizer: 第12回生体機能研究会
  • Place of Presentation: 群馬県・ホテル木暮 (伊香保温泉)
• [Presentation] Role of VE-PTP in shear stress responses of endothelial cells
  • Author(s): Isnainiasih Mantilidewi Kemala, Yoji Murata, Munemasa Mori, Takenori Kotani, Shinya Kusakari, Hideki Okazawa, Hiroshi Ohnishi, Takashi Matozaki
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 神奈川県・パシフィコ横浜
• [Presentation] 腸上皮の恒常性維持におけるチロシンホスファターゼShp2の役割/Roles of the protein tyrosine phosphatase Shp2 in maintaining homeostasis of the intestinal epithelium
  • Author(s): 小谷武徳、山下博成、村田陽二、岡澤秀樹、大西浩史、具英成、的崎尚
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 神奈川県・パシフィコ横浜
• [Presentation] 成熟腸上皮細胞の寿命決定の分子基盤/Molecular basis for regulation of the life span of intestinal epithelial cells
  • Author(s): 的崎尚、小谷武徳、村田陽二
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 神奈川県・パシフィコ横浜
• [Presentation] 細胞質型チロシンホスファターゼShp2の成熟脳における機能解析
  • Author(s): 草苅伸也、橋本美穂、柴崎貢志、吾郷由希夫、松田敏夫、Benjamin G. Neel、小谷武徳、村田陽二、的崎尚、大西浩史
  • Organizer: 第60回北関東医学会総会
  • Place of Presentation: 群馬県・群馬大学医学部 刀城会館
• [Presentation] SIRPαによる脾臓T細胞の恒常性の調節
  • Author(s): 橋本美穂、齊藤泰之、金子哲也、大西浩史、草苅伸也、小谷武徳、村田陽二、岡澤秀樹、的崎尚
  • Organizer: 第60回北関東医学会総会
  • Place of Presentation: 群馬県・群馬大学医学部 刀城会館
• [Presentation] 腸上皮の恒常性維持におけるチロシンホスファターゼShp2 の役割/Roles of the protein tyrosine phosphatase Shp2 in maintaining homeostasis of the intestinal epithelium
  • Author(s): 山下博成、小谷武徳、村田陽二、岡澤秀樹、大西浩史、具英成、的崎尚
  • Organizer: 第72回日本癌学会 学術総会
  • Place of Presentation: 神奈川県・パシフィコ横浜
• [Presentation] 受容体型チロシンホスファターゼSAP-1 による腸管免疫制御/Regulation of intestinal immunity by the protein tyrosine phosphatase SAP-1
  • Author(s): 村田陽二、小谷武徳、Supriatna Yana 、森宗昌、草苅伸也、岡澤秀樹、大西浩史、的崎尚
  • Organizer: 第72回日本癌学会 学術総会
  • Place of Presentation: 神奈川県・パシフィコ横浜
• [Presentation] Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases
  • Author(s): Takashi Matozaki
  • Organizer: The 2nd Taiwan-Japan Bilateral Conference on Protein Phosphatases
  • Place of Presentation: 台湾・国家衛生研究院（新竹市）
  • Invited
• [Presentation] R3 受容体型チロシンホスファターゼの発現、局在と生理機能
  • Author(s): 的崎尚、村田陽二、小谷武徳、Yana Supriatna、森宗昌、岡澤秀樹、大西浩史
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫県・神戸国際会議場 他
• [Presentation] SIRPα-CD47 system regulates the homeostasis of dendritic cells in lymphoid tissues
  • Author(s): Ken Washio, Takenori Kotani, Datu Respatika, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Atsushi Fukunaga, Chikako Nishigori, Takashi Matozaki
  • Organizer: 第42回日本免疫学会 学術集会
  • Place of Presentation: 千葉県・幕張メッセ
• [Presentation] 細胞質型チロシンホスファターゼShp2による脳機能制御
  • Author(s): 草苅伸也、齋藤文仁、橋本美穂、柴崎貢志、吾郷由紀夫、小谷武徳、村田陽二、松田敏夫、Benjamin G. Neel、的崎尚、大西浩史
  • Organizer: 第6回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 三重県・三重大学
• [Presentation] 腸上皮の恒常性維持におけるチロシンホスファターゼShp2の役割
  • Author(s): 小谷武徳、山下博成、朴貞河、村田陽二、岡澤秀樹、大西浩史、具英成、的崎尚
  • Organizer: 第6回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 三重県・三重大学
• [Presentation] 樹状細胞及び二次リンパ組織の恒常性維持におけるＳＩＲＰαの役割
  • Author(s): 鷲尾健、小谷武徳、レスパティカ ダトゥ、村田陽二、岡澤秀樹、大西浩史、福永淳、錦織千佳子、的崎尚
  • Organizer: 第6回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 三重県・三重大学
• [Presentation] SIRPα-CD47 system regulates the homeostasis of dendritic cells in lymphoid tissues
  • Author(s): Ken Washio, Takenori Kotani, Datu Respatika, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Atsushi Fukunaga, Chikako Nishigori, Takashi Matozaki
  • Organizer: ワシントン大学・神戸大学国際合同シンポジウム
  • Place of Presentation: USA・ワシントン大学（シアトル）
• [Presentation] Role of VE-PTP in shear stress responses of endothelial cells
  • Author(s): Isnainiasih Mantilidewi Kemala, Yoji Murata, Munemasa Mori, Takenori Kotani, Shinya Kusakari, Hideki Okazawa, Hiroshi Ohnishi, Takashi Matozaki
  • Organizer: ワシントン大学・神戸大学国際合同シンポジウム
  • Place of Presentation: USA・ワシントン大学（シアトル）
• [Presentation] Roles of protein tyrosine phosphatases in homeostasis of intestinal epithelium
  • Author(s): Takashi Matozaki
  • Organizer: ワシントン大学・神戸大学国際合同シンポジウム
  • Place of Presentation: USA・ワシントン大学（シアトル）
• [Presentation] 樹状細胞におけるチロシンホスファターゼＳｈｐ１の欠損は自己免疫疾患を誘導する
  • Author(s): Kaneko T
  • Organizer: 第５６回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル 新高輪
• [Presentation] Importance of The Protein Tyrosine Phosphatase Shp1 In Dendritic Cells for Prevention of Th1 Cell Differentiation And Autoimmunity: A Potential Target for the Therapy
  • Author(s): Kaneko T
  • Organizer: EULAR2012（European League Against Rheumatism 2012）（欧州リウマチ学会議）
  • Place of Presentation: ドイツ・ベルリン
• [Presentation] 細胞質型チロシンホスファターゼShp2の成熟脳における機能解析
  • Author(s): 草苅伸也
  • Organizer: 第11回生体機能研究会
  • Place of Presentation: 神奈川県・箱根プリンスホテル・レイクサイドアネックスコテージ
• [Presentation] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain
  • Author(s): Kusakari S
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry/ The 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: 兵庫県・神戸国際会議場
• [Presentation] The phosphotyrosine Signaling and its Deregulation in Inflammation and Cancers
  • Author(s): Matozaki T
  • Organizer: 2nd Bandung Biomolecular Medicine Conference
  • Place of Presentation: インドネシア・パジャジャラン大学
  • Invited
• [Presentation] Roles of vascular endothelial protein tyrosine phosphatase (VE-PTP) in endothelial cells
  • Author(s): Mantilidewi KI
  • Organizer: 2nd Bandung Biomolecular Medicine Conference
  • Place of Presentation: インドネシア・パジャジャラン大学
• [Presentation] Regulation of brain functions by a protein tyrosine phosphatase Shp2
  • Author(s): Kusakari S
  • Organizer: International Synapse Research Workshop 2012
  • Place of Presentation: 愛知県・岡崎コンファレンスセンター
• [Presentation] Protein tyrosine phosphatases and the CD47-SIRPα System that mediates cell-to-cell communication
  • Author(s): Matozaki T
  • Organizer: The First Taiwan Phosphatase Conference
  • Place of Presentation: 台湾・国立成功大学（National Cheng Kung University）
  • Invited
• [Presentation] 細胞質型チロシンホスファターゼShp2の成熟脳における機能解析
  • Author(s): 草苅伸也
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡県・福岡国際会議場 他
• [Presentation] 脾臓T細胞の恒常性調節へのSIRPαの関与
  • Author(s): 橋本（佐藤）美穂
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡県・福岡国際会議場 他
• [Presentation] Regulation of intestinal immunity by the protein tyrosine phosphatase SAP-1
  • Author(s): Murata Y
  • Organizer: 第10回プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 東京都・国立がん研究センター
• [Presentation] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain
  • Author(s): Kusakari S
  • Organizer: 第10回プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 東京都・国立がん研究センター
• [Presentation] Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell diffierentiation and induces autoimmunity
  • Author(s): Kotani T
  • Organizer: 第10回プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 東京都・国立がん研究センター
• [Presentation] Tyrosine phosphorylation of CEACAM20 and its functional roles
  • Author(s): Daniwijaya EW
  • Organizer: 第10回プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 東京都・国立がん研究センター
• [Remarks] 神戸大学大学院医学研究科生化学・分子生物学講座シグナル統合学分野
  • URL: http://www.med.kobe-u.ac.jp/tougou/signal/Home.html
• [Remarks] 神戸大学大学院医学研究科 生化学・分子生物学講座 シグナル統合学分野
  • URL: http://www.med.kobe-u.ac.jp/tougou/signal/Home.html
• [Remarks] 神戸大学大学院医学研究科 生化学・分子生物学講座 シグナル統合学分野
  • URL: http://www.med.kobe-u.ac.jp/tougou/signal/Home.html
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/tougou/signal/index.html