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Experimental analysis of conformational evolution process of a prion by developing the kinetic NMR

Research Project

Project/Area Number 23370068
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics
Research InstitutionGifu University

Principal Investigator

KUWATA Kazuo  岐阜大学, 連合創薬医療情報研究科, 教授 (00170142)

Co-Investigator(Kenkyū-buntansha) KAMATARI Yuji  岐阜大学, 生命科学総合研究支援センター, 助教 (70342772)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
KeywordsNMR / キネティクス / プリオン / 立体構造進化 / 活性化
Research Abstract

In order to elucidate the conformational conversion process of a prion protein from its cellular form to the pathogenic one and the prion's evolution mechanism, we created a series of novel apparatuses, i.e. kinetic fluorescence, kinetic CD, kinetic DLS, and kinetic NMR (800 MHz). Using these novel analytical systems, we could detect the early conformational changes in a prion protein prior to the aggregation formation. Using the kinetic DLS, we detected the transient formation of disordered assembly before the stable amyloid-like aggregate formation. Using the kinetic NMR, we could detect the region specific degradation of the peptide bonds by imposing the ultrasonication. Those phenomena would give us important clues for understanding the mechanism of conformational conversion as well as that of evolution.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (76 results)

All 2014 2013 2012 2011

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (52 results) (of which Invited: 9 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] FK506reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice.2013

    • Author(s)
      Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R.
    • Journal Title

      Autophagy.

      Volume: 9 Issue: 9 Pages: 1386-1394

    • DOI

      10.4161/auto.25381

    • NAID

      120006986076

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography2013

    • Author(s)
      Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
    • Journal Title

      ChemMedChem

      Volume: 8(7) Issue: 7 Pages: 1035-1039

    • DOI

      10.1002/cmdc.201300167

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for AKR1B102013

    • Author(s)
      Satoshi Endo, Dawei HU, Miho Suyama, Toshiyuki Matsunaga, Kenji Sugimoto, Yuji Matsuya, Ossama El-Kabbani, Kazuo Kuwata, Akira Hara, Yukio Kitade, Naoki Toyooka
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 21(21) Issue: 21 Pages: 6378-6384

    • DOI

      10.1016/j.bmc.2013.08.059

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nearly Reversible Conformational Change of Amyloid Fibrils as Revealed by pH-Jump Experiments2013

    • Author(s)
      Kei-ichi Yamaguchi, Yuji O. Kamatari, Mayuko Fukuoka, Reiji Miyaji, Kazuo Kuwata
    • Journal Title

      Biochemistry

      Volume: 52(39) Issue: 39 Pages: 6797-6806

    • DOI

      10.1021/bi400698u

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Logical Design of Medical Chaperone for Prion Diseases2013

    • Author(s)
      Kuwata Kazuo
    • Journal Title

      Current topics in medicinal chemistry

      Volume: 13(19) Issue: 19 Pages: 2432-2440

    • DOI

      10.2174/15680266113136660171

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein-Specific Force Field Derived from the Fragment Molecular Orbital Method can Improve Protein-Ligand Binding Interactions2013

    • Author(s)
      L. Chang, T. Ishikawa, K. Kuwata, and S. Takada
    • Journal Title

      J. Comp. Chem

      Volume: vol. 34 Issue: 14 Pages: 1251-1257

    • DOI

      10.1002/jcc.23250

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A theoretical study of the two binding modes between lysozyme and tri-NAG with an explicit solvent model based on the fragment molecular orbital method2013

    • Author(s)
      T. Ishikawa, R. R. Burri, Y. O. Kamatari, S. Sakuraba, N. Matubayasi, A. Kitao, and K. Kuwata
    • Journal Title

      Phys. Chem. Chem. Phys

      Volume: 15 Issue: 10 Pages: 3646-3654

    • DOI

      10.1039/c3cp42761g

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free-energy analysis of lysozyme-triNAG binding modes with all-atom molecular dynamics simulation combined with the solution theory in the energy representation2013

    • Author(s)
      K. Takemura, R. R. Burri, T. Ishikawa, T. Ishikura, S. Sakuraba, N. Matubayasi, K. Kuwata, and A. Kitao
    • Journal Title

      Chem. Phys. Lett

      Volume: 559 Pages: 94-98

    • DOI

      10.1016/j.cplett.2012.12.063

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-prion activity of an RNA aptamer and its structural basis2013

    • Author(s)
      Mashima, T., Nishikawa, F., Kamatari Y. O., Fujiwara, H., Saimura, M., Nagata, T., Kodaki, T., Nishikawa, S., Kuwata, K., Katahira, M.
    • Journal Title

      Nucleic Acids Research

      Volume: 41 Issue: 2 Pages: 1355-1362

    • DOI

      10.1093/nar/gks1132

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A minimal implementation of the AMBER-PAICS interface for Ab initio FMO-QM/MM-MD simulation2013

    • Author(s)
      Takuya Okamoto, Takeshi Ishikawa, Yoshiyuki Koyano, Norifumi Yamamoto, Kazuo Kuwata, Masataka Nagaoka
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 86(2) Issue: 2 Pages: 210-222

    • DOI

      10.1246/bcsj.20120216

    • NAID

      10031155742

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization antiprion compounds based on their binding properties to prion proteins : Implications as medical chaperons2013

    • Author(s)
      Yuji O. Kamatari
    • Journal Title

      Protein Science

      Volume: 22 Issue: 1 Pages: 22-34

    • DOI

      10.1002/pro.2180

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A minimal implementation of the AMBER-PAICS interface for Ab initio FMO-QM/MM-MD simulation.2013

    • Author(s)
      Takuya Okamoto
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 86(2) Issue: 5 Pages: 210-222

    • DOI

      10.1002/jcc.21678

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase2012

    • Author(s)
      Yamada K, Koyama H, Hagiwara K, Ueda A, Sasaki Y, Kanesashi SN, Ueno R, Nakamura HK, Kuwata K, Shimizu K, Suzuki M, Aida Y
    • Journal Title

      Microbes and infection/Institut Pasteur

      Volume: 14(9) Issue: 9 Pages: 740-747

    • DOI

      10.1016/j.micinf.2012.02.012

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-commutative Geometrical Drug Discovery<br/>&mdash;The Principle of Geometrical Regulation&mdash;2012

    • Author(s)
      桑田一夫
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 132 Issue: 8 Pages: 873-879

    • DOI

      10.1248/yakushi.132.873

    • NAID

      130001888704

    • ISSN
      0031-6903, 1347-5231
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus2012

    • Author(s)
      Takemura T, Urushisaki T, Fukuoka M, Hosokawa-Muto J, Hata T, Okuda Y, Hori S, Tazawa S, Araki Y, Kuwata K
    • Journal Title

      Evid.Based Complement.Alternat.Med.

      Volume: (in press) Pages: 1-7

    • DOI

      10.1155/2012/946867

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process2012

    • Author(s)
      Kei-chi Yamaguchi
    • Journal Title

      Protein Science

      Volume: VOL 21 Issue: 1 Pages: 38-49

    • DOI

      10.1002/pro.755

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-based discovery of anti-influenza virus A compounds among medicines2012

    • Author(s)
      Fukuoka M., et al
    • Journal Title

      Biochim.Biophys.Acta.

      Volume: 1820 Issue: 2 Pages: 90-95

    • DOI

      10.1016/j.bbagen.2011.11.003

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RI-MP2 Gradient Calculation of Large Molecules Using the Fragment Molecular Orbital Method2011

    • Author(s)
      Takeshi Ishikawa, Kazuo Kuwata
    • Journal Title

      The journal of physical chemistry letters

      Volume: 3(3) Issue: 3 Pages: 375-379

    • DOI

      10.1021/jz201697x

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Respiratory and cardiovascular toxicity studies of a novel antiprion compound, GN8, in rats and dogs2011

    • Author(s)
      Hosokawa-Muto J, Kimura T, Kuwata K
    • Journal Title

      Drug.Chem.Toxicol.

      Volume: (in press) Issue: 3 Pages: 264-271

    • DOI

      10.3109/01480545.2011.598533

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells2011

    • Author(s)
      Kimura T, Hosokawa-Muto J, Asami K, Murai T, Kuwata K
    • Journal Title

      Eur.J.Med.Chem.

      Volume: 46 Issue: 11 Pages: 5675-5679

    • DOI

      10.1016/j.ejmech.2011.08.039

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deciphering the Molecular Details for the Binding of the Prion Protein to Main Ganglioside GM1 of Neuronal Membranes2011

    • Author(s)
      Sanghera N, Correia BE, Correia JR, Ludwig C, Agarwal S, Nakamura HK, Kuwata K, Samain E, Gill AC, Bonev BB, Pinheiro TJ
    • Journal Title

      Chemistry & biology

      Volume: 18(11) Issue: 11 Pages: 1422-31

    • DOI

      10.1016/j.chembiol.2011.08.016

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] フラグメント分子軌道法プログラム「PAICS」と統合創薬プログラム「NAGARA」2011

    • Author(s)
      石川岳志, 石倉孝一, 桑田一夫
    • Journal Title

      Molecular Science

      Volume: 5

    • URL

      http://j-molsci.jp/article/2011_1.html

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] メディカルシャペロンによるプリオン病の治療2014

    • Author(s)
      桑田一夫
    • Organizer
      プリオンに関する講演会
    • Place of Presentation
      臨床研究情報センター
    • Year and Date
      2014-03-18
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] X線自由電子レーザーによるアミロイド線維の一分子構造解析を目指して2014

    • Author(s)
      山口圭一, 桑田一夫
    • Organizer
      第三回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
    • Place of Presentation
      岐阜大学医学部
    • Year and Date
      2014-03-18
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] プリオン蛋白質が形成するアミロイド線維の構造とダイナミクス.「プリオン病及び遅発性ウイルス感染症に関する調査研究班プリオン班」「プリオン病のサーベイランスと感染予防に関する調査研究班」2014

    • Author(s)
      桑田一夫
    • Organizer
      平成25年度合同研究報告会
    • Place of Presentation
      アルカディア市ヶ谷
    • Related Report
      2013 Final Research Report
  • [Presentation] Logical design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2014

    • Author(s)
      ワリード・ オスマン, 桑田一夫
    • Organizer
      第7回武田科学振興財団薬科学シンポジウム
    • Place of Presentation
      武田薬品研修所
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] リオン蛋白質が形成するアミロイド線維の構造とダイナミクス2014

    • Author(s)
      桑田一夫
    • Organizer
      「プリオン病及び遅発性ウイルス感染症に関する調査研究班プリオン班」「プリオン病のサーベイランスと感染予防に関する調査研究班」平成25年度合同研究報告会
    • Place of Presentation
      アルカディア市ヶ谷
    • Related Report
      2013 Annual Research Report
  • [Presentation] 論理的創薬から治験薬GMPへ2013

    • Author(s)
      桑田一夫
    • Organizer
      岐阜構造生物学・医学・論理的創薬研究会&岐阜超高磁場NMR利用研究会
    • Place of Presentation
      岐阜大学医学部
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] プリオン病新規治療薬P092の開発について2013

    • Author(s)
      桑田一夫
    • Organizer
      プリオン病研修会
    • Place of Presentation
      ノーベルファーマ株式会社
    • Year and Date
      2013-02-27
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Structure-based drug design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2013

    • Author(s)
      ワリード・ オスマン, 桑田一夫
    • Organizer
      Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting
    • Place of Presentation
      東京大学本郷キャンパス
    • Related Report
      2013 Final Research Report
  • [Presentation] Application アミロイド22013

    • Author(s)
      桑田一夫
    • Organizer
      X-FEL第2回会合
    • Place of Presentation
      独立行政法人理化学研究所池之端研究棟セミナー室
    • Related Report
      2013 Final Research Report
  • [Presentation] Nearly reversible conformational change of H2 amyloid fibrils as revealed by pH-jump experiments2013

    • Author(s)
      山口圭一, 鎌足雄司, 福岡万佑子, 宮地礼司 , 桑田一夫
    • Organizer
      Asian Pacific Prion Symposium 2013
    • Place of Presentation
      ハウステンボス
    • Related Report
      2013 Final Research Report
  • [Presentation] Medical chaperone- a novel strategy for the logical drug design for prion diseases2013

    • Author(s)
      桑田一夫
    • Organizer
      Asian Pacific Prion Symposium 2013
    • Place of Presentation
      ハウステンボス
    • Related Report
      2013 Final Research Report
  • [Presentation] Logical design of a medical chaperone for prion diseases2013

    • Author(s)
      桑田一夫
    • Organizer
      韓国蛋白質学会
    • Place of Presentation
      大田広域市, 韓国
    • Related Report
      2013 Final Research Report
  • [Presentation] ダブルpHジャンプによるH2アミロイド線維のほぼ可逆的な構造変化2013

    • Author(s)
      山口圭一, 鎌足雄司, 福岡万佑子, 宮地礼司, 桑田一夫
    • Organizer
      第13回蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] MEDICAL CHAPERONE - A NOVEL STRATEGY FOR THE LOGICAL DRUG DESIGN2013

    • Author(s)
      桑田一夫
    • Organizer
      DRUG DISCOVERY & THERAPY WORLD CONGRESS 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] メディカルシャペロンと抗プリオン物質の分類.プリオン病及び遅発性ウイルス感染症に関する調査研究班」2013

    • Author(s)
      桑田一夫
    • Organizer
      「プリオン病のサーベイランスと感染予防に関する調査研究班」合同研究報告会
    • Place of Presentation
      アルカディア市ヶ谷
    • Related Report
      2013 Final Research Report
  • [Presentation] MEDICAL CHAPERONE - A NOVEL STRATEGY FOR THE LOGICAL DRUG DESIGN.2013

    • Author(s)
      桑田一夫
    • Organizer
      DRUG DISCOVERY & THERAPY WORLD CONGRESS 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Logical design of a medical chaperone for prion diseases.2013

    • Author(s)
      桑田一夫
    • Organizer
      韓国蛋白質学会
    • Place of Presentation
      大田広域市,韓国
    • Related Report
      2013 Annual Research Report
  • [Presentation] Medical chaperone- a novel strategy for the logical drug design for prion diseases.2013

    • Author(s)
      桑田一夫
    • Organizer
      Asian Pacific Prion Symposium 2013
    • Place of Presentation
      ハウステンボス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Application アミロイド22013

    • Author(s)
      桑田一夫
    • Organizer
      X-FEL第2回会合
    • Place of Presentation
      独立行政法人理化学研究所 池之端研究棟セミナー室
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nearly reversible conformational change of H2 amyloid fibrils as revealed by pH-jump experiments.2013

    • Author(s)
      山口圭一、鎌足雄司、福岡万佑子、宮地礼司、桑田一夫
    • Organizer
      Asian Pacific Prion Symposium 2013
    • Place of Presentation
      ハウステンボス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structure-based drug design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2013

    • Author(s)
      ワリード・オスマン、桑田一夫
    • Organizer
      Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting
    • Place of Presentation
      東京大学 本郷キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] メディカルシャペロンと抗プリオン物質の分類2013

    • Author(s)
      桑田一夫
    • Organizer
      プリオン病及び遅発性ウイルス感染症に関する調査研究班」、「プリオン病のサーベイランスと感染予防に関する調査研究班」合同研究報告会
    • Place of Presentation
      アルカディア市ヶ谷
    • Related Report
      2012 Annual Research Report
  • [Presentation] 論理的創薬から治験薬GMPへ2013

    • Author(s)
      桑田一夫
    • Organizer
      岐阜構造生物学・医学・論理的創薬研究会 & 岐阜超高磁場NMR利用研究会
    • Place of Presentation
      岐阜大学医学部
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Relaxation Matrix and Prion2012

    • Author(s)
      桑田一夫
    • Organizer
      蛋白研セミナー 「 International Workshop on Pharmaceutical NMR-Nucleic Acids and Prion Protein-」
    • Place of Presentation
      大阪大学蛋白質研究所
    • Year and Date
      2012-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] プリオン蛋白質のコンフォメーションスイッチと核依存性複製機構2012

    • Author(s)
      桑田一夫
    • Organizer
      東京医科歯科大学特別講義
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2012-06-19
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] 特殊及び一般形態形成理論-非可換外科学入門-2012

    • Author(s)
      桑田一夫
    • Organizer
      慶應義塾大学講演
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2012-05-26
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] 自己複製する蛋白質'プリオン'の制御2012

    • Author(s)
      桑田一夫
    • Organizer
      日本胎盤臨床研究会
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2012-05-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 論理的創薬法の確立と抗プリオン化合物の創製シーズ創製のための戦略的組織-人獣感染防御研究センター-2012

    • Author(s)
      桑田一夫
    • Organizer
      臨床研究情報センター講演
    • Place of Presentation
      臨床研究情報センター
    • Year and Date
      2012-04-11
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 電界放出型透過電子顕微鏡によるアミロイド線維の観察2012

    • Author(s)
      山口圭一
    • Organizer
      第1回岐阜構造生物学・医学・論理的創薬研究会シンポジウム「構造生物学・医学・論理的創薬の拠点構築を目指して」
    • Place of Presentation
      岐阜大学医学部
    • Year and Date
      2012-03-23
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 論理的創薬に基づく疾患治療法の開発2012

    • Author(s)
      桑田一夫
    • Organizer
      第1回岐阜構造生物学・医学・論理的創薬研究会シンポジウム「構造生物学・医学・論理的創薬の拠点構築を目指して」
    • Place of Presentation
      岐阜大学医学部
    • Year and Date
      2012-03-23
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 論理的創薬に基づく疾患治療法の開発2012

    • Author(s)
      桑田一夫
    • Organizer
      難治性疾患統合創薬PJ第11回セミナー
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2012-03-19
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Mechanism of Medicinal Chaperone to Block the Prion' s Pathogenic Conversion Process2012

    • Author(s)
      桑田一夫
    • Organizer
      3rd Nagasaki Prion Symposium
    • Place of Presentation
      長崎大学良順会館
    • Year and Date
      2012-01-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanism of Medicinal Chaperone to Block the Prion's Pathogenic Conversion Process2012

    • Author(s)
      桑田一夫
    • Organizer
      3rd Nagasaki Prion Symposium
    • Place of Presentation
      長崎大学良順会館
    • Year and Date
      2012-01-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Basic study on the anti-influenza effects of Brazilian green propolis extracts2012

    • Author(s)
      Tomoaki Takemura, Tomohiko Urushisaki, Yoko Araki, Kenji Ichihara, Kazuo Kuwata
    • Organizer
      APIMONDIA APIMEDICA-APIQUALITY INTERNATIONAL FORUM
    • Place of Presentation
      Zhenjiang, China
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] HOME CARE OF CHILDREN WITH FOP (FIBRODYSPLASIA OSSIFICANS PROGRESSIVA)2012

    • Author(s)
      Hiromi Kuwata
    • Organizer
      The 4th Congress of the European Academy of Paediatric Societies (EAPS)
    • Place of Presentation
      Istanbul, Turley
    • Related Report
      2013 Final Research Report
  • [Presentation] X線回折・NMR融合アミロイド線維イメージング2012

    • Author(s)
      桑田一夫
    • Organizer
      X-FEL第1回会合
    • Place of Presentation
      理化学研究所播磨研究所放射光科学総合研究センター
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of anti-prion compounds according to the binding properties to the prion protein2012

    • Author(s)
      Yuji O. Kamatari
    • Organizer
      The 26th Annual Symposium
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] HOME CARE OF CHILDREN WITH FOP (FIBRODYSPLASIA OSSIFICANS PROGRESSIVA)2012

    • Author(s)
      Hiromi Kuwata
    • Organizer
      The 4th Congress of the European Academy of Paediatric Societies (EAPS)
    • Place of Presentation
      Istanbul,Turley
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization of anti-prion compounds according to the binding properties to the prion protein.2012

    • Author(s)
      Yuji O. Kamatari
    • Organizer
      The 26th Annual Symposium
    • Place of Presentation
      San Diego,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] X線回折・NMR融合アミロイド線維イメージング2012

    • Author(s)
      桑田一夫
    • Organizer
      X-FEL第1回会合
    • Place of Presentation
      理化学研究所 播磨研究所 放射光科学総合研究センター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Relaxation Matrix and Prion2012

    • Author(s)
      桑田一夫
    • Organizer
      蛋白研セミナー「International Workshop on Pharmaceutical NMR-Nucleic Acids and Prion Protein-」
    • Place of Presentation
      大阪大学蛋白質研究所
    • Related Report
      2012 Annual Research Report
  • [Presentation] 論理的創薬法の確立と抗プリオン化合物の創製 シーズ創製のための戦略的組織-人獣感染防御研究センター-2012

    • Author(s)
      桑田一夫
    • Organizer
      臨床研究情報センター講演
    • Place of Presentation
      臨床研究情報センター
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 自己複製する蛋白質‘プリオン’の制御2012

    • Author(s)
      桑田一夫
    • Organizer
      日本胎盤臨床研究会
    • Place of Presentation
      東京ステーションコンファレンス
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 量子ロボット医薬品の設計2011

    • Author(s)
      桑田一夫
    • Organizer
      味の素株式会社招待講演
    • Place of Presentation
      味の素株式会社イノベーション研究所
    • Year and Date
      2011-12-03
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Invited
  • [Presentation] プリオン蛋白質のコンホメーションスイッチ2011

    • Author(s)
      桑田一夫
    • Organizer
      第4回タンパク質の異常凝集とその防御・修復機構に関する研究会
    • Place of Presentation
      京都大学原子炉実験所
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] プリオンは, 何故, 自己複製するか?2011

    • Author(s)
      桑田一夫
    • Organizer
      大学院連合創薬医療情報研究科公開講座「先端を行く連合創薬医療情報研究科」
    • Place of Presentation
      岐阜薬科大学
    • Year and Date
      2011-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] プリオンは、何故、自己複製するか?2011

    • Author(s)
      桑田一夫
    • Organizer
      大学院連合創薬医療情報研究科公開講座「先端を行く連合創薬医療情報研究科」
    • Place of Presentation
      岐阜薬科大学
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prion Dynamics and Logical Drug Design2011

    • Author(s)
      桑田一夫
    • Organizer
      Israel-Japan Joint Symposium on Biophysics "Protein Dynamics : From single molecules to whole cell"
    • Place of Presentation
      兵庫県立大学
    • Year and Date
      2011-09-16
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 立体構造進化と論理的創薬を担う岐阜大NMR拠点2011

    • Author(s)
      桑田一夫
    • Organizer
      大阪大学蛋白質研究所セミナー「先端的NMR拠点から生まれる新たな潮流 : 最新成果, 役割, 利用」
    • Place of Presentation
      大阪大学蛋白質研究所
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulating the Prion Conformation by Logical Drug Design2011

    • Author(s)
      桑田一夫
    • Organizer
      Asian Pacific Prion Symposium 2011
    • Place of Presentation
      ホテルマロウド軽井沢
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] マウスプリオン蛋白質のアミロイド線維形成を促進する超音波パワーの定量2011

    • Author(s)
      山口圭一
    • Organizer
      Asian Pacific Prion Symposium 2011
    • Place of Presentation
      ホテルマロウド軽井沢
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 立体構造進化と論理的創薬を担う岐阜大NMR拠点2011

    • Author(s)
      桑田一夫
    • Organizer
      大阪大学蛋白質研究所セミナー「先端的NMR拠点から生まれる新たな潮流:最新成果,役割,利用」
    • Place of Presentation
      大阪大学蛋白質研究所
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗プリオン化合物のマレイン酸塩及その製造方法, 並びにその医薬組成物2014

    • Inventor(s)
      桑田一夫
    • Industrial Property Rights Holder
      国立大学法人岐阜大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-023838
    • Filing Date
      2014-02-10
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 抗プリオン化合物のマレイン酸塩及びその製造方法、並びにその医薬組成物2014

    • Inventor(s)
      桑田 一夫
    • Industrial Property Rights Holder
      国立大学法人 岐阜大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-023838
    • Filing Date
      2014-02-10
    • Related Report
      2013 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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