• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research on signal transduction via transcriptional mediators

Research Project

Project/Area Number 23370079
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Molecular biology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

ISHII Shunsuke  独立行政法人理化学研究所, 石井分子遺伝学研究室, 上席研究員 (00124785)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords転写メディエーター / シグナル伝達 / 転写アダプター / TRIM27 / Shn-2 / 転写制御 / メディエーター / 転写 / T細胞 / 分化 / アポトーシス
Research Abstract

We found that corepressor Ski binds to TRIM27, and that TRIM27 contributes to deubiquitination via forming a complex with USP7. It was found that TRIM27 enters into the nucleus in response to poly(I-C) stimulation, suggesting that Ski ubiquitination may be regulated by TRIM27 in response to specific signaling.
In knockout mice of transcriptional adaptor Shn-2, T cell differentiation in thymus is blocked. It was found that Shn-2 is modified by O-GlcNAc at several sites which modulates nuclear entry of Shn-2. It was demonstrated that Shn-2 is localized on the T-cell receptor beta gene locus, and modulated allelic exclusion.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (41 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 1 results) Presentation (26 results) (of which Invited: 4 results) Remarks (1 results)

  • [Journal Article] Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells2014

    • Author(s)
      Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K, Ishii S
    • Journal Title

      Cell Stem Cell

      Volume: 14(2) Issue: 2 Pages: 217-227

    • DOI

      10.1016/j.stem.2013.12.015

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis.2013

    • Author(s)
      1. Zaman MM, Nomura T, Takagi T, Okamura T, Jin W, Shinagawa T, Tanaka Y, Ishii S
    • Journal Title

      Mol Cell Biol

      Volume: 33 Issue: 24 Pages: 4971-4984

    • DOI

      10.1128/mcb.00465-13

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trim27-deficient mice are susceptible to streptozotocin-induced diabetes.2013

    • Author(s)
      Zaman MM, Ishii S 他
    • Journal Title

      FEBS Open Bio.

      Volume: 4 Issue: 1 Pages: 60-64

    • DOI

      10.1016/j.fob.2013.12.002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk2013

    • Author(s)
      Seong KH & Ishii S
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 1 Pages: 66-78

    • DOI

      10.1111/gtc.12018

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013

    • Author(s)
      Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
    • Journal Title

      Neuropsychopharmacology

      Volume: 38(8) Issue: 8 Pages: 1409-25

    • DOI

      10.1038/npp.2013.38

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation2012

    • Author(s)
      Kanei-Ishii C, Nomura T, Egoh A & Ishii S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 426 Issue: 1 Pages: 59-64

    • DOI

      10.1016/j.bbrc.2012.08.032

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inheritance and memory of stress-induced epigenome change : roles played by the ATF-2 family of transcription factors2012

    • Author(s)
      Seong KH, Maekawa T & Ishii S
    • Journal Title

      Genes Cells

      Volume: 17 Issue: 4 Pages: 249-263

    • DOI

      10.1111/j.1365-2443.2012.01587.x

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inheritance and memory of stress-induced epigenome change : roles played by the ATF-2 family of transcription factors2012

    • Author(s)
      Seong KH, Maekawa T, Ishii S
    • Journal Title

      Genes to Cells

      Volume: 17(In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dampening of death pathways by schnurri-2 is essential for T-cell development2011

    • Author(s)
      Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S, Glimcher LH
    • Journal Title

      Nature

      Volume: 472 Issue: 7341 Pages: 105-109

    • DOI

      10.1038/nature09848

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inheritance of stress-induced, ATF-2-dependent epigenetic change2011

    • Author(s)
      Seong KH, Li D, Shimizu H, Nakamura R, Ishii S
    • Journal Title

      Cell

      Volume: 145 Issue: 7 Pages: 1049-1061

    • DOI

      10.1016/j.cell.2011.05.029

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy2011

    • Author(s)
      Nagao, M., Saita, Y., Hanyu, R., Hemmi, H., Notomi, T., Hayata, T., Nakamoto, T., Nakashima, K., Kaneko, K., Kurosawa, H., Ishii, S., Ezura, Y., Noda, M
    • Journal Title

      J Cell Physiol

      Volume: 226 Issue: 3 Pages: 573-538

    • DOI

      10.1002/jcp.22521

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conditional knockdown of target gene expression by tetracycline regulated transcription of double strand RNA2011

    • Author(s)
      Hou, X., Omi, M., Harada, H., Ishii, S., Takahashi, Y., Nakamura, H.
    • Journal Title

      Dev Growth Differ

      Volume: 53 Issue: 1 Pages: 69-75

    • DOI

      10.1111/j.1440-169x.2010.01229.x

    • NAID

      10027899337

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ribosomal protein L4 positively regulates activity of a c- m y b proto-oncogene product2010

    • Author(s)
      Egoh A, Kanesashi S, Kanei-Ishii C, Nomura T & Ishii S
    • Journal Title

      Genes Cells

      Volume: 15 Issue: 8 Pages: 829-841

    • DOI

      10.1111/j.1365-2443.2010.01421.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal2010

    • Author(s)
      Seong KH, Akimaru H, Dai P, Nomura T, Okada M & Ishii S
    • Journal Title

      PLOS One

      Volume: 5 Issue: 12 Pages: e15365-e15365

    • DOI

      10.1371/journal.pone.0015365

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates TNF- α-induced apoptosis2013

    • Author(s)
      Zaman MM, Nomura T, Takagi T, Okamura T, Jin W, Shinagawa T, Tanaka Y, Ishii S
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Inheritance of stress-induced epigenome changes2013

    • Author(s)
      Ishii S
    • Organizer
      Small RNAs to Stem Cells & Epigenetic Reprograming Asia-2013 Meeting
    • Place of Presentation
      University of Tokyo, Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Inheritance of stress-induced chromatin alterations2013

    • Author(s)
      Ishii S
    • Organizer
      Gordon Conference on Epigenetics : Mechanisms and Implications
    • Place of Presentation
      Bryant University, Smithfield, RI, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Inheritance of stress-induced chromatin alterations.2013

    • Author(s)
      Ishii S
    • Organizer
      Gordon Conference on Epigenetics
    • Place of Presentation
      Bryant University, Smithfield, RI, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ATF-7 controls epigenetic memory of pathogen infection in macrophages.2013

    • Author(s)
      Yoshida K, Ishii S 他
    • Organizer
      Gordon Conference on Epigenetics
    • Place of Presentation
      Bryant University, Smithfield, RI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inheritance of stress-induced epigenome changes.2013

    • Author(s)
      Ishii S
    • Organizer
      Small RNAs to Stem Cells & Epigenetic Reprograming Asia-2013 Meeting
    • Place of Presentation
      Univ. of Tokyo, Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Inheritance of stress-dependent epigenetic change in Drosophila melanogaster.2013

    • Author(s)
      Seong KH, Ishii S 他
    • Organizer
      8th World Congress on Developmental Origins of Health and Disease
    • Place of Presentation
      Suntec International Convention and Exhibition Centre, Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] 拘束ストレスにより誘導されるエピゲノム変化の遺伝2013

    • Author(s)
      成耆鉉、石井俊輔
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 転写因子ATF-7を介したストレスによるテロメアの長さの制御2013

    • Author(s)
      前川利男、石井俊輔 他
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 卵子に大量に存在するヒストンバリアントによる 核のリプログラミング2013

    • Author(s)
      品川敏恵、石井俊輔 他
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates TNF-α-induced apoptosis2013

    • Author(s)
      Zaman MM, Ishii S 他
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia2012

    • Author(s)
      宮川剛, 高雄啓三, 萩原英雄, 大平耕司, 昌子浩孝, 服部聡子, 小清水久嗣, 梅森十三, 高木豪, 石井俊輔
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Role of ATF-2 family transcription factors in inheritance of epigenetic change induced by stress2012

    • Author(s)
      Ishii S
    • Organizer
      Joint Meeting of the 45th JSDB & the 64th JSCB
    • Place of Presentation
      Kobe Convention Center, Kobe
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of ATF-2 family transcription factors in inheritance of epigenetic change induced by stress2012

    • Author(s)
      石井俊輔
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエにおけるストレス依存的エピジェネティック制御とその遺伝の解析2012

    • Author(s)
      成耆鉉
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] マクロファージの炎症時におけるATF-7の機能解析2012

    • Author(s)
      吉田圭介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転写因子ATF-7を介したストレスによるテロメアの長さの制御2012

    • Author(s)
      前川利男
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] ストレスによるエピゲノム変化の遺伝2012

    • Author(s)
      石井俊輔
    • Organizer
      第85回日本生化学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ストレスはATF-7を介してヘテロクロマチン形成とテロメアの長さを制御する2011

    • Author(s)
      前川利男, 吉田圭介, Binbin Liu, 仲村賢一, 田久保海誉, 石井俊輔
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] ATF-7は炎症の抑制因子として機能する2011

    • Author(s)
      吉田圭介, 前川利男, Claire Renard-Guillet, 白髭克彦, 石井俊輔
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inheritance of stress-induced epigenome change : research using fly and mouse2011

    • Author(s)
      石井俊輔
    • Organizer
      第34回日本分子生物学会年会ワークショップ
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 環境・代謝ストレスによるエピジェネティック変化と疾患2011

    • Author(s)
      石井俊輔
    • Organizer
      第2回Molecular Cardiovascular Conference II
    • Place of Presentation
      小樽(招待講演)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inheritance of stress-induced epigenome change : research using fly and mouse2011

    • Author(s)
      Ishii S
    • Organizer
      The 34th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Related Report
      2013 Final Research Report
  • [Presentation] Positive selection に必要な転写因子 Schnurr-2 の chip on chip法を用いた解析2010

    • Author(s)
      高木豪, 石井俊輔
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of relationship between TRIM27 and USP7 through ubiquitination and deubiquitination2010

    • Author(s)
      野村照明, Zaman MM , 石井俊輔
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Epigenetic regulation by ATF-2 family of transcription factors in response to various stresses, Symposium on "Epigenetic inheritance and genome reprogramming"2010

    • Author(s)
      Ishii S
    • Organizer
      The 62nd Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      Osaka International Convention Center, Osaka, Japan
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://rtcweb.rtc.riken.jp/lab/mg/mg.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi