Analyses of mechanisms regulating the traveling and splitting of stripe patterns
| Project/Area Number |
23370095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | JT Biohistory Research Hall |
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Principal Investigator |
ODA Hiroki 株式会社生命誌研究館, その他部局等, 研究員 (50396222)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | パターン形成 / 体節形成 / 細胞間シグナル / 反応拡散 / 節足動物 / 縞パターン / 発生•分化 / 発生・分化 / パターン形 |
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| Research Abstract |
This work was aimed at elucidating molecular mechanisms underlying the traveling and splitting of a wave of hedgehog expression, which is observed for head segmentation in the embryo of the spider Parasteatoda tepidariorum, an emerging model arthropod that belongs to the Chelicerata. We carried out an embryonic RNA interference screen for genes whose knockdowns affected the behavior of the wave of hedgehog expression and identified armadillo and axin, which are known as regulators of wingless signaling. Detailed analyses of the phenotypes showed that the absence of armadillo activity prevented the hedgehog wave from behaving dynamically and made the hedgehog expression independent of orthodenticle. Our findings revealed a part of the mechanisms of hedgehog wave traveling and splitting.
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Report
(4 results)
Research Products
(32 results)
