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Evolution of Eye as sensory organ

Research Project

Project/Area Number 23370098
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionNational Institute of Genetics

Principal Investigator

IKEO KAZUHO  国立遺伝学研究所, 生命情報研究センター, 准教授 (20249949)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords分子進化 / 眼の起源 / 次世代シークエンス / ゲノム比較 / クラゲ / 感覚器 / レンズ眼 / 比較ゲノム / NGSシークエンサー / オプシン遺伝子 / 渦鞭毛虫 / NGS / 遺伝子発現
Research Abstract

To understand the process and origin of various eyes, I conducted comparative evolutionary study by using next generation sequence technology. For the purpose, I took two different types of Jellyfish with and without eye and also dinoflagellate with different types of lens eye. RNA-seq by next generation sequence technology performed collection of gene expression profiles of the species. The visual pigment of dinoflagellate showed the similarity with bacterial pigment and it suggests the origin of their eye-like structure related to bacterial origin. The other side, the result of jellyfish showed the molecules related their lens development evolutionaliry related with our genes, thus, jellyfish already gain molecular system for lens conformation before establishing nervous system. Now, we still continue more fine analysis of the data.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (7 results) (of which Invited: 2 results)

  • [Journal Article] Longitudinal clinical course of three Japanese patients with Leber congenital amaurosis/early-onset retinal dystrophy with RDH12 mutation2014

    • Author(s)
      Kuniyoshi K, Sakuramoto H, Yoshitake K, Abe K, Ikeo K, Furuno M, Tsunoda K, Kusaka S, Shimomura Y, Iwata T
    • Journal Title

      Doc Ophthalmol

      Volume: 128(3) Pages: 219-28

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autosomal recessive cone-rod dystrophy associated with compound heterozygous mutations in the EYS gene2014

    • Author(s)
      Katagiri S, Akahori M, Hayashi T, Yoshitake K, Gekka T, Ikeo K, Tsuneoka H, Iwata T
    • Journal Title

      Doc Ophthalmol

      Volume: 128(3) Pages: 211-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autosomal recessive cone-rod dystrophy associated with compound heterozygous mutations in the EYS gene.2014

    • Author(s)
      Katagiri S, Akahori M, Hayashi T, Yoshitake K, Gekka T, Ikeo K, Tsuneoka H, Iwata T.
    • Journal Title

      Doc Ophthalmol.

      Volume: 128(3) Issue: 3 Pages: 211-217

    • DOI

      10.1007/s10633-014-9435-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-exome sequencing identifies a novel ALMS1 mutation (p.Q2051X) in two Japanese brothers with Alströ m syndrome2013

    • Author(s)
      Katagiri S, Yoshitake K, Akahori M, Hayashi T, Furuno M, Nishino J, Ikeo K, Tsuneoka H, Iwata T
    • Journal Title

      Mol Vis

      Volume: 19 Pages: 2393-406

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of gene expression profile of epiretinal membranes obtained from eyes with proliferative vitreoretinopathy to that of secondary epiretinal membranes2013

    • Author(s)
      Asato R, Yoshida S, Ogura A, Nakama T, Ishikawa K, Nakao S, Sassa Y, Enaida H, Oshima Y, Ikeo K, Gojobori T, Kono T, Ishibashi T
    • Journal Title

      PLoS One

      Volume: 8(1)

    • NAID

      120005227330

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary changes of multiple visual pigment genes in the complete genome of Pacific bluefin tuna.2013

    • Author(s)
      Nakamura Y, Mori K, Saitoh K, Oshima K, Mekuchi M, Sugaya T, Shigenobu Y, Ojima N, Muta S, Fujiwara A, Yasuike M, Oohara I, Hirakawa H, Chowdhury VS, Kobayashi T, Nakajima K, Sano M, Wada T, Tashiro K, Ikeo K, Hattori M, Kuhara S, Gojobori T, Inouye K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 110(27) Issue: 27 Pages: 11061-11066

    • DOI

      10.1073/pnas.1302051110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of gene expression profile of epiretinal membranes obtained from eyes with proliferative vitreoretinopathy to that of secondary epiretinal membranes2013

    • Author(s)
      Asato R, et. al.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 1 Pages: e54191-e54191

    • DOI

      10.1371/journal.pone.0054191

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The First Symbiont-Free Genome Sequence of Marine Red Alga, Susabi-nori(Pyropia yezoensis).2013

    • Author(s)
      Nakamura Y.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 3 Pages: e57122-e57122

    • DOI

      10.1371/journal.pone.0057122

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new database (GCD) on genome composition for eukaryote and prokaryote genome sequences and their initial analyses2012

    • Author(s)
      Kirill Kryukov
    • Journal Title

      Genome Biology and Evolution

      Volume: 4 Issue: 4 Pages: 501-512

    • DOI

      10.1093/gbe/evs026

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary patterns of recently emerged animal duplogs2011

    • Author(s)
      Ezawa K, Ikeo K, Gojobori T, Saitou N
    • Journal Title

      Genome Biol Evol

      Volume: 3 Pages: 1119-35

    • DOI

      10.1093/gbe/evr074

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective gene collection from the metatranscriptome of marine microorganisms2011

    • Author(s)
      Ogura A, Lin M, Shigenobu Y, Fujiwara A, Ikeo K, Nagai S
    • Journal Title

      BMC Genomics

      Volume: 12 Suppl 3 Issue: Suppl 3 Pages: S15-S15

    • DOI

      10.1186/1471-2164-12-s3-s15

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Gene duplication and diversity of species.2012

    • Author(s)
      Kazuho Ikeo
    • Organizer
      日本地球惑星科学連合2012年度連合大会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Computational Tools for NGS Data Analysis2012

    • Author(s)
      Kazuho Ikeo
    • Organizer
      Next Generation Sequencing Asia Congress
    • Place of Presentation
      Singapore
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Comparative analysis of gene expression for convergent evolution of camera eye between octopus and human2011

    • Author(s)
      Kazuho Ikeo
    • Organizer
      Genomic Conversation and Diversity of Organisms
    • Place of Presentation
      Taiwan(招待講演)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生物進化における遺伝子重複と多様性2011

    • Author(s)
      Kazuho Ikeo
    • Organizer
      第6回地文台シンポジウム&東工大流動機構国際ワークショップ
    • Place of Presentation
      東京工業大学(東京都)(招待講演)
    • Year and Date
      2011-11-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genome wide data analysis by using NGS2011

    • Author(s)
      Kazuho Ikeo
    • Organizer
      Next Generation Sequencing Asia Congress
    • Place of Presentation
      Singapore(招待講演)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genome wide data analysis by using NGS2011

    • Author(s)
      Kazuho Ikeo
    • Organizer
      SMBE2011
    • Place of Presentation
      Kyoto(招待講演)
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transcriptome analysis by using large scale sequencing2011

    • Author(s)
      Kazuho Ikeo
    • Organizer
      Bioinformatics Symposium
    • Place of Presentation
      Korea(招待講演)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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