Influence of vitamin K status to physiological polymorphism of bone metabolism
| Project/Area Number |
23370105
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied anthropology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
AOYAGI Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80295071)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OSAKI Makoto 長崎大学, 医歯薬学総合研究科(医学系), 教授 (20380959)
HONDA Sumihisa 長崎大学, 医歯薬学総合研究科(保健学系), 教授 (90244053)
ABE Yasuyo 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (90372771)
|
|---|
| Project Period (FY) |
2011-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
|
|---|
| Keywords | ビタミンK / 骨代謝 / 骨粗鬆症 / 生理的多型性 / 運動機能 / 踵骨超音波法 / ビタミンＫ |
|---|
| Outline of Final Research Achievements |
We studied Vitamin K status using serum undercarboxylated osteocalcin (ucOC), and examined the association of ucOC with low bone mass contributing to fragile fracture, adjusting for age, body size (body mass index: BMI) and physical performance (5-times chair stand time). Subjects were 1127 community-dwelling people (461 men and 666 women). We conducted multiple linear regression analysis. In men, bone mass (stiffness index) was negatively associated with age. BMI had a borderline association. No association was found between bone mass and ucOC or 5-times chair stand time. In women, bone mass (stiffness index) was negatively associated with ucOC, age and 5-times chair stand time, and was positively associated with BMI.
|
Report
(5 results)
Research Products
(9 results)
