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Influence of vitamin K status to physiological polymorphism of bone metabolism

Research Project

Project/Area Number 23370105
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied anthropology
Research InstitutionNagasaki University

Principal Investigator

AOYAGI Kiyoshi  長崎大学, 医歯薬学総合研究科(医学系), 教授 (80295071)

Co-Investigator(Kenkyū-buntansha) OSAKI Makoto  長崎大学, 医歯薬学総合研究科(医学系), 教授 (20380959)
HONDA Sumihisa  長崎大学, 医歯薬学総合研究科(保健学系), 教授 (90244053)
ABE Yasuyo  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (90372771)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
KeywordsビタミンK / 骨代謝 / 骨粗鬆症 / 生理的多型性 / 運動機能 / 踵骨超音波法 / ビタミンK
Outline of Final Research Achievements

We studied Vitamin K status using serum undercarboxylated osteocalcin (ucOC), and examined the association of ucOC with low bone mass contributing to fragile fracture, adjusting for age, body size (body mass index: BMI) and physical performance (5-times chair stand time). Subjects were 1127 community-dwelling people (461 men and 666 women). We conducted multiple linear regression analysis. In men, bone mass (stiffness index) was negatively associated with age. BMI had a borderline association. No association was found between bone mass and ucOC or 5-times chair stand time. In women, bone mass (stiffness index) was negatively associated with ucOC, age and 5-times chair stand time, and was positively associated with BMI.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (9 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (4 results) Remarks (3 results)

  • [Journal Article] Accuracy of spinal curvature assessed by a computer-assisted device and anthropometric indicators in discriminating vertebral fractures among individuals with back pain2014

    • Author(s)
      Mizukami S, Abe Y, Tsujimoto R, Arima K, Kanagae M, Chiba G, Aoyagi K
    • Journal Title

      Osteoporos Int

      Volume: 25 Issue: 6 Pages: 1727-1734

    • DOI

      10.1007/s00198-014-2680-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of spinal inclination with physical performance measures among community-dwelling Japanese women aged 40 years and older2013

    • Author(s)
      Abe Y, Aoyagi K et al.
    • Journal Title

      Geriatrics & gerontology international

      Volume: 13 Issue: 4 Pages: 881-886

    • DOI

      10.1111/ggi.12020

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脊柱傾斜角及び脊椎椎体変形と日常生活動作困難との関連2014

    • Author(s)
      安部恵代,有吉拓也,西村貴孝,有馬和彦,青柳 潔
    • Organizer
      第16回日本骨粗鬆症学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-10-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中高年男性における骨吸収マーカーと骨量との関連2014

    • Author(s)
      西村貴孝,安部恵代,有馬和彦,青柳 潔
    • Organizer
      第16回日本骨粗鬆症学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-10-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Relationship between undercarboxylated osteocalcin, bone turnover and bone mass among Japanese men and women2012

    • Author(s)
      Abe Y
    • Organizer
      International Congress of Physiological Anthropology
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of Walking Difficulty on Bone Mass and Bone Turnover in Japanese People Aged 40 Years and Over

    • Author(s)
      Abe Y, Aoyagi K, Arima K
    • Organizer
      American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2013 Annual Research Report
  • [Remarks] 長崎大学大学院医歯薬学総合研究科公衆衛生学

    • URL

      http://www.med.nagasaki-u.ac.jp/public-h/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 長崎大学大学院医歯薬学総合研究科公衆衛生学

    • URL

      http://www.med.nagasaki-u.ac.jp/public-h/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/public-h/

    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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