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Elucidation of individual variability on the skin blood flow by frequency analysis and multi-scale analysis

Research Project

Project/Area Number 23370107
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied anthropology
Research InstitutionKyushu University (2012-2014)
Shibaura Institute of Technology (2011)

Principal Investigator

KUDO Susumu  九州大学, 工学(系)研究科(研究院), 教授 (70306926)

Co-Investigator(Kenkyū-buntansha) SERA Toshihiro  九州大学, 大学院工学研究院, 准教授 (40373526)
TADA Shigeru  防衛大学校, 応用科学群, 教授 (70251650)
HAMASAKI Keita  芝浦工業大学, 工学部, 教授 (50348900)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords皮膚血流 / 内皮細胞 / ウェーブレット解析 / 皮膚血液循環 / 人類学 / 生理学 / 循環器・呼吸器 / 細胞・組織 / 循環器・高血圧
Outline of Final Research Achievements

Skin blood vessel will dilate and constrict with changes in peripheral temperature. Cold induced vasodilation (CIVD) in the finger tips occurs after the start of local cold exposure of the extremities. Heat induced vasoconstriction (HIVC) elicited by local heating have been observed. However, the mechanism of CIVD and HIVC is still not clear. Wavelet analysis of blood flow reveals various peaks in the power spectrum corresponding to specific origins: (1) cardiac activity,(2) respiratory activity, (3) myogenic activity, (4) neurogenic activity, and (5) endothelial activity. We investigated which factors are dominant to CIVD and HIVC. We also investigated the effect of light exposure on skin blood flow. It was found that endothelial, neurogenic, and myogenic activity were related to CIVD, and neurogenic and myogenic activity was related to HIVC. It was also found that endothelial, neurogenic, and myogenic activity related to decrease of blood flow under blue light exposure.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (43 results)

All 2015 2014 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (37 results) (of which Invited: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 血管内皮細胞の力学・化学環境と物質輸送2014

    • Author(s)
      工藤奨
    • Journal Title

      伝熱

      Volume: 55 Pages: 16-21

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Effect of Flow Load on Hepatic Function in Co-Culture of Hepatocytes with Hepatic Stellate Cells and Endothelial Cells: Relationship between Hepatic Function and Nitric Oxide Concentration <I>in vitro</I>2012

    • Author(s)
      Tateki Sumii
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 7 Issue: 2 Pages: 237-247

    • DOI

      10.1299/jbse.7.237

    • NAID

      130002066906

    • ISSN
      1880-9863
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 寒冷血管拡張反応時の皮膚血流応答に及ぼす環境温の影響2012

    • Author(s)
      工藤奨
    • Journal Title

      日本生理人類学会誌

      Volume: 17 Pages: 15-21

    • NAID

      110009426340

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] せん断流れ場でのIP_3誘導による内皮細間Ca^<2+>応答伝播2011

    • Author(s)
      工藤奨
    • Journal Title

      日本機械学会論文集

      Volume: 77-784 Pages: 2431-2441

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 寒冷血管拡張反応における皮膚血流量のウェーブレット解析2015

    • Author(s)
      大和慈,中嶋和弘,世良俊博,工藤奨
    • Organizer
      日本機械学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] つつき刺激時における血管内皮細胞内PKCα動態の調査2015

    • Author(s)
      稗田健一,荒井雅貴, 中嶋和弘,世良俊博,工藤奨
    • Organizer
      日本機械学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 力学刺激時の内皮細胞内タンパク質移動現象2015

    • Author(s)
      工藤奨
    • Organizer
      日本機械学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-01-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 物理・化学刺激に対する細胞内物質移動現象2014

    • Author(s)
      工藤奨
    • Organizer
      山口大学
    • Place of Presentation
      山口
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Direct load of nitric oxide affect hepatic function2014

    • Author(s)
      Tateki SUMII, Yohei NAKANO, Kazuhiro NAKASHIMA, Toshihiro SERA, Susumu KUDO
    • Organizer
      The Seventh Kyushu University-KAIST Joint Workshop on Frontiers in Mechanical Engineering
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肝細胞機能に及ぼす一酸化窒素の影響2014

    • Author(s)
      隅井干城,阿部拓磨,中嶋和弘,世良俊博,工藤奨
    • Organizer
      バイオレオロジー学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-05 – 2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 引張刺激時における細胞内ROCK2局在の観察2012

    • Author(s)
      土屋宏紀
    • Organizer
      日本機械学会
    • Place of Presentation
      千葉
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低酸素下の流体せん断応力がeNOSの活性に及ぼす影響2012

    • Author(s)
      上山慶一
    • Organizer
      日本機械学会
    • Place of Presentation
      千葉
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 温度刺激による血管内皮細胞内eNOS局在への影響2012

    • Author(s)
      糸井一真
    • Organizer
      日本機械学会
    • Place of Presentation
      千葉
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウェーブレット変換によるCIVD反応時の血流解析2011

    • Author(s)
      大倉脩平
    • Organizer
      日本生理人類学会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Wavelet Analysis of oscillations in the peripheral blood flow during cold-induced vasodilation and heat-induced vasoconstriction

    • Author(s)
      Okura S,Nakashima K ,Kudo S.
    • Organizer
      The 11th International Congress of Physiological Anthropology
    • Place of Presentation
      Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effectof Shear Stress on Migration of Hepatic Stellate Cells

    • Author(s)
      Tateki SUMII, Ryosuke FUJITA, Kazuhiro NAKASHIMA, Susumu KUDO
    • Organizer
      The 15th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血管内皮細胞内PKCαの局在変化におよぼす局所引張りの影響

    • Author(s)
      隅井干城,木村恭彰,島田知弥,土屋宏紀,工藤奨
    • Organizer
      第36回日本バイオレオロジー学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝星細胞の遊走における力学刺激と受容体の関連性

    • Author(s)
      隅井干城,藤田陵佑,岩下洸,工藤奨
    • Organizer
      第36回日本バイオレオロジー学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] せん断応力負荷時の血管内皮細胞内アクチン局在特性

    • Author(s)
      荒井雅貴,寺田麻理枝,工藤奨
    • Organizer
      第36回日本バイオレオロジー学年年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝星細胞の遊走におけるせん断応力の大きさと方向の影響

    • Author(s)
      隅井干城,藤田陵佑,岩下洸,工藤奨
    • Organizer
      生体医工学シンポジウム2013
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 流れ方向とせん断応力の大きさが肝星細胞遊走に与える影響

    • Author(s)
      隅井干城,藤田陵佑,岩下洸,工藤奨
    • Organizer
      第49回九大生体材料・力学研究会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] つつき刺激時による血管内皮細胞PKCα分布の変化, 第26回バイオエンジニアリング講演会

    • Author(s)
      高良智尋, 荒井雅貴,中嶋和弘,工藤奨
    • Organizer
      第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 引張刺激時における血管内皮細胞PKCαの局在変化

    • Author(s)
      西村一馬, 荒井雅貴,中嶋和弘,工藤奨
    • Organizer
      第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 一酸化窒素直接負荷による肝細胞機能への影響

    • Author(s)
      隅井干城,阿部拓磨,中嶋和弘,世良俊博,工藤奨
    • Organizer
      日本生理人類学会研究奨励発表会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 一酸化窒素(NO)による肝機能向上の研究

    • Author(s)
      阿部拓磨, 隅井干城, 中嶋 和弘, 世良俊博,工藤 奨
    • Organizer
      日本機械学会九州学生会第45回卒業研究発表会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 引張り刺激による血管内皮細胞内PKCaの移動解析

    • Author(s)
      永島達也, 西村和馬, 中嶋 和弘, 世良俊博,工藤奨
    • Organizer
      日本機械学会九州学生会第45回卒業研究発表会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] つつき刺激による血管内皮細胞内PKCαの動態解析

    • Author(s)
      山本幹大, 高良智尋, 中嶋 和弘, 世良俊博,工藤 奨
    • Organizer
      日本機械学会九州学生会第45回卒業研究発表会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] せん断応力負荷時における肝星細胞の遊走の変化

    • Author(s)
      藤田陵佑
    • Organizer
      日本バイオレオロジー学会年会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 引張刺激時における細胞内ROCK2局在の観察

    • Author(s)
      工藤奨
    • Organizer
      日本バイオレオロジー学会年会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] Movement characteristics of protein kinase Cα in vascular endothelial cells following single cell stimulation

    • Author(s)
      Susumu Kudo
    • Organizer
      14th INTERNATIONAL CONGRESS OF BIORHEOLOGY and 7th INTERNATIONAL CONFERENCE ON CLINICAL HEMORHEOLOGY
    • Place of Presentation
      Istanbul
    • Related Report
      2012 Annual Research Report
  • [Presentation] Wavelet Analysis of Oscillations in the Peripheral Blood Flow during Cold Induced Vasodilation

    • Author(s)
      Susumu Kudo
    • Organizer
      International Congress of Physiological Anthropology
    • Place of Presentation
      Beijing
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mechanical Stimulation Induces Movement of Protein Kinase C in Vascular Endothelial Cells

    • Author(s)
      Susumu Kudo
    • Organizer
      Ninth International Conference on Flow Dynamics
    • Place of Presentation
      Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] HIVC 反応時のウェーブレット解析

    • Author(s)
      大倉脩平
    • Organizer
      2012 年度日本生理人類学会研究奨励発表会(関東地区)
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 視覚刺激時における血流変化の解析

    • Author(s)
      佐古健太朗
    • Organizer
      2012 年度日本生理人類学会研究奨励発表会(関東地区)
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラバーハンドイリュージョンが及ぼす生体反応への影響

    • Author(s)
      舩戸麻里子
    • Organizer
      2012 年度日本生理人類学会研究奨励発表会(関東地区)
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] せん断応力負荷時の血管内皮細胞内Actin の局所的特性

    • Author(s)
      寺田麻理枝
    • Organizer
      2012 年度日本生理人類学会研究奨励発表会(関東地区)
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低酸素環境におけるニューロン活性化が与える脳血管への影響

    • Author(s)
      佐藤竜也
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会
    • Place of Presentation
      筑波
    • Related Report
      2012 Annual Research Report
  • [Presentation] せん断応力負荷時における肝星細胞の遊走とPDGFBBの関連性

    • Author(s)
      藤田陵佑
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会
    • Place of Presentation
      筑波
    • Related Report
      2012 Annual Research Report
  • [Presentation] 局所引張り刺激による細胞内PKC αの局在変化

    • Author(s)
      木村恭彰
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会
    • Place of Presentation
      筑波
    • Related Report
      2012 Annual Research Report
  • [Presentation] 温度変化における神経細胞の活性変化

    • Author(s)
      角掛祐斗
    • Organizer
      平成24 年度日本生理人類学会研究奨励発表会(関西地区)
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Translocation of Protein Kinase Cα in Endothelial Cells Following Mechanical Stimulation

    • Author(s)
      Susumu Kudo
    • Organizer
      International Symposium on Bio Medical Sngineering Interface
    • Place of Presentation
      Sendai
    • Related Report
      2012 Annual Research Report
  • [Book] 人間科学の百科事典2015

    • Author(s)
      日本生理人類学会編
    • Total Pages
      782
    • Publisher
      丸善出版
    • Related Report
      2014 Annual Research Report
  • [Remarks]

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K004580/research.html#30740313502698932318

    • Related Report
      2014 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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