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Toxin and elicitor: a comparative analysis of functions and pathological roles of cell death inducers from plant pathogenic fungi

Research Project

Project/Area Number 23380025
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Plant pathology
Research InstitutionTottori University

Principal Investigator

KODAMA Motoichiro  鳥取大学, 農学部, 教授 (00183343)

Co-Investigator(Kenkyū-buntansha) YOSHIOKA Hirofumi  名古屋大学, 生命農学研究科, 准教授 (30240245)
Co-Investigator(Renkei-kenkyūsha) KAMINAKA Hironori  鳥取大学, 農学部, 准教授 (40397849)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords植物病原菌 / 毒素 / エリシター / 細胞死
Research Abstract

Toxins and elicitors from plant pathogens appear to be functional as virulence and avirulence factors, respectively. While, both factors have a common role as an inducer for programmed cell death in plant cells. In the project, we showed evidence that cell death in a host plant induced by both host-specific toxins and elicitors leads to the compatible reaction in the infection process of necrotrophic plant pathogen. Both the toxin and the elicitor might act as pathogenicity factors in host-necrotrophic pathogen interactions. In addition, the results indicate that cell death cascades triggered by those factors might be mediated by different signaling pathways induced by each factor.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (53 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (35 results) (of which Invited: 4 results) Book (4 results)

  • [Journal Article] Ethylene-responsive AP2/ERF transcription factor MACD1 participates in phytotoxin-triggered programmed cell death2013

    • Author(s)
      Mase, K., Ishihama, N., Mori, H., T akahashi, H., Kaminaka, H., Kodama, M. and Y oshioka, H
    • Journal Title

      Molecular Plant-Microbe Interactions

      Volume: 26 Pages: 868-879

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonhost resistance of A r a bidopsis tha lia na against A lter na r ia a lter na ta involves both pre- and postinvasive defenses but is collapsed by AAL-toxin in the absence of LOH22013

    • Author(s)
      Egusa, M., Miwa, T, Kaminaka, H., T akano, Y . and Kodama, M
    • Journal Title

      Phytopathology

      Volume: 103 Pages: 733-740

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonhost resistance of Arabidopsis thaliana against Alternaria alternata involves both pre- and postinvasive defenses but is collapsed by AAL-toxin in the absence of LOH2.2013

    • Author(s)
      Egusa M, Miwa T, Kaminaka H, Takano Y, Kodama M.
    • Journal Title

      Phytopathology

      Volume: 103 Issue: 7 Pages: 733-740

    • DOI

      10.1094/phyto-08-12-0201-r

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host-selective toxins produced by the plant pathogenic fungus Alternaria alternata2013

    • Author(s)
      Takashi Tsuge
    • Journal Title

      FEMS Microbiology Reviews

      Volume: 37 Issue: 1 Pages: 44-66

    • DOI

      10.1111/j.1574-6976.2012.00350.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alternaria属菌の病原性進化2013

    • Author(s)
      赤木靖典
    • Journal Title

      植物防疫

      Volume: 67 Pages: 15-19

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethylene-responsive AP2/ERF transcription 1 factor MACD1 participates in phytotoxin-triggered programmed cell death2013

    • Author(s)
      Mase, K.
    • Journal Title

      Molecular Plant-Microbe Interactions

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonhost resistance of Arabidopsis thaliana against Alternaria alternata involves both pre- and post invasive defenses but is collapsed by AAL-toxin in the absence of LOH22013

    • Author(s)
      Egusa, M.
    • Journal Title

      Phytopathology

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethylene signaling pathway and MAPK cascades are required for AAL-toxin-induced programmed cell death2012

    • Author(s)
      Mase, K., Mizuno, T ., Ishihama, N., Fujii, T ., Mori, H., Kodama, M. and Yoshioka, H
    • Journal Title

      Molecular Plant-Microbe Interactions

      Volume: 25 Pages: 1015-1025

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fungal growth and in planta distribution of host-specific AAL-toxin in tomato plants infected with the tomato pathotype of Alternaria alternata2012

    • Author(s)
      Kheder A.A., Akagi, Y ., T akao, K., Akamatsu, H. and Kodama, M
    • Journal Title

      Mycotoxins

      Volume: 62 Pages: 7-13

    • NAID

      10030541351

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ethylene analog and 1-methylcyclopropene enhance black spot disease development in Pyrus pyrifolia Nakai2012

    • Author(s)
      Itai, A., Igori, T ., Fujita, N., Egusa, M., Kodama, M. and Murayama H
    • Journal Title

      HortScience

      Volume: 47 Pages: 228-231

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of the melanin biosynthesis genes A LM1 and BRM2-1 in the tomato pathotype of Alternaria alternata2012

    • Author(s)
      Kheder A.A., Akagi, Y ., Y anaga, K., Maekiawa, N., Otani, H., T suge, T . and Kodama, M
    • Journal Title

      Journal of General Plant Pathology

      Volume: 78 Pages: 30-38

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of the ceramide synthase gene ALT7, a homolog of the disease resistance gene Asc1, in the plant pathogen Alternaria alternata2012

    • Author(s)
      Kheder, A. A., Akagi, Y., Tsuge, T., and Kodama, M
    • Journal Title

      J. Plant Pathol. Microbiol.

      Volume: S2 Issue: S2

    • DOI

      10.4172/2157-7471.s2-001

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of the melanin biosynthesis genes ALM1 and BRM2-1 in the tomato pathotype of Alternaria alternata2012

    • Author(s)
      Kheder A.A.
    • Journal Title

      Journal of General Plant Pathology

      Volume: 78 Pages: 30-38

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethylene Analog and 1-Methylcyclopropene Enhance Black Spot Disease Development in Pyrus pyrifolia Nakai2012

    • Author(s)
      Itai, A.
    • Journal Title

      HortScience

      Volume: 47 Pages: 228-231

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 非病原性 Alternaria alternata への宿主特異的 AAL 毒素生合成遺伝子クラスター導入による AAL 毒素前駆体産生株の作出2014

    • Author(s)
      高尾和実・ 赤木靖典・ 柘植尚志・ 難波栄二・児玉基一朗
    • Organizer
      平成26年度日本植物病理学会大会
    • Place of Presentation
      札幌コンベンションセンター, 札幌
    • Year and Date
      2014-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Pathogenicity chromosomes in host-specific toxin-producing Alternaria species2014

    • Author(s)
      Kodama, M., Akagi, Y ., Takao, K. and Tsuge, T
    • Organizer
      12th European Conference on Fungal Genetics
    • Place of Presentation
      Seville, Spain
    • Year and Date
      2014-03-25
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Pathogenicity chromosomes in host-specific toxin-producing Alternaria species2014

    • Author(s)
      Kodama, M., Akagi, Y., Takao, K. and Tsuge, T.
    • Organizer
      12th European Conference on Fungal Genetics
    • Place of Presentation
      Hotel Silken Al Andalus, Seville, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 非病原性 Alternaria alternata における宿主特異的 AAL 毒素生合成遺伝子クラスター導入菌株の作出と解析2013

    • Author(s)
      高尾和実・ 赤木靖典・ 柘植尚志・ 難波英二・児玉基一朗
    • Organizer
      平成25年度日本植物病理学会関西部会
    • Place of Presentation
      岡山大学創立五十周年記念館, 岡山市
    • Year and Date
      2013-09-26
    • Related Report
      2013 Final Research Report
  • [Presentation] AAL 毒素生合成遺伝子クラスターとフモニシン生合成遺伝子クラスターの比較解析2013

    • Author(s)
      赤木靖典 ・ 柘植尚志 ・ 石原 亨 ・ 難波英二・児玉基一朗
    • Organizer
      日本マイコトキシン学会学術講演会
    • Place of Presentation
      大阪府立大学, 大阪市
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Alternaria alternata 植物病原菌の宿主特異的毒素生産における global regulator LaeA ホモログの関与2013

    • Author(s)
      高尾和実・ 赤木靖典・ 柘植尚志・ 石原 亨・難波英二・ 児玉基一朗
    • Organizer
      日本マイコトキシン学会学術講演会
    • Place of Presentation
      大阪府立大学, 大阪市
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Biosynthetic pathway for host-specific AAL-toxin in the tomato pathotype of Alternaria alternata2013

    • Author(s)
      Akagi, Y ., Tsuge, T . and Kodama, M
    • Organizer
      10th International Congress of Plant Pathology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2013-08-26
    • Related Report
      2013 Final Research Report
  • [Presentation] AaLAEA, a methyltransferase gene homolog, controls biosynthesis of secondary metabolites and pathogenicity in the multi pathotypes of Alternaria alternata2013

    • Author(s)
      Takao, K., Akagi, Y ., Tsuge, T ., Namba, E. and Kodama, M
    • Organizer
      10th International Congress of Plant Pathology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2013-08-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Alternaria alternata 病原菌の宿主特異的毒素生産における global regulator LaeA ホモログの関与2013

    • Author(s)
      高尾和実・ 赤木靖典・ 播本佳明・ 柘植尚志・難波栄二・ 児玉基一朗
    • Organizer
      平成25年度日本植物病理学会大会
    • Place of Presentation
      岐阜大学, 岐阜市
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Biosynthetic pathway for host-specific AAL-toxin in the tomato pathotype of Alternaria alternata2013

    • Author(s)
      Akagi, Y., Tsuge, T. and Kodama, M
    • Organizer
      10th International Congress of Plant Pathology
    • Place of Presentation
      Beijing International Convention Centre, Beijing, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] AaLAEA, a methyltransferase gene homolog, controls biosynthesis of secondary metabolites and pathogenicity in the multi pathotypes of Alternaria alternata2013

    • Author(s)
      Tanao, K., Akagi, Y., Tsuge, T., Namba, E. and Kodama, M.
    • Organizer
      10th International Congress of Plant Pathology
    • Place of Presentation
      Beijing International Convention Centre, Beijing, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非病原性Alternaria alternataにおける宿主特異的AAL毒素生合成遺伝子クラスター導入菌株の作出と解析2013

    • Author(s)
      高尾和実・赤木靖典・柘植尚志・難波英二・児玉基一朗
    • Organizer
      日本植物病理学会関西部会
    • Place of Presentation
      岡山大学50周年記念館、岡山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 植物病原糸状菌における二次代謝産物生合成と病原性 - ゲノム解析からみた進化・多様性. 植物-病原微生物の相互作用研究の新展開2012

    • Author(s)
      児玉基一朗・赤木靖典・高尾和実・柘植尚志
    • Organizer
      平成24年度日本植物病理学会感染生理談話
    • Place of Presentation
      近江八幡市
    • Year and Date
      2012-09-01
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 植物病原性Alternariaにおける病原性の進化と分化-遺伝子水平移動が関与か?-2012

    • Author(s)
      赤木靖典
    • Organizer
      日本植物病理学植物病原菌類談話会
    • Place of Presentation
      福岡国際会議場(福岡市)(招待講演)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 植物病原性Alternaria における病原性の進化と分化 -遺伝子水平移動が関与か?-2012

    • Author(s)
      赤木靖典・児玉基一朗
    • Organizer
      平成24年度日本植物病理学植物病原菌類談話会
    • Place of Presentation
      福岡国際会議場, 福岡市
    • Year and Date
      2012-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 病 原 性Alternaria alternata に お け る global regulator LaeA ホモログの機能と病理学的役割2012

    • Author(s)
      高尾和実 ・ 赤木靖典 ・ 柘植尚志 ・ 播本佳明・尾 谷 浩 ・ 児 玉 基 一 朗
    • Organizer
      平成24年度日本植物病理学会大会
    • Place of Presentation
      福岡国際会議場, 福岡市
    • Year and Date
      2012-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Ethylene signaling pathway and MAPK cascades are required for AAL-toxin-induced programmed cell death2012

    • Author(s)
      Mase, K.
    • Organizer
      2nd Korea-Japan Joint Symposium and the 2012 Annual Meeting of PSJ
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural analysis of a conditionally dispensable pathogenicity chromosome of the tomato pathotype of Alternaria alternata2012

    • Author(s)
      Akagi, Y.
    • Organizer
      2nd Korea-Japan Joint Symposium and the 2012 Annual Meeting of PSJ
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] AP2/ERF 型転写因子である AtMACD1 は毒素細胞死に関与する2012

    • Author(s)
      間瀬圭介 ・ 石濱伸明 ・ 森 仁志 ・ 上中弘典・児玉基一朗・吉岡博文
    • Organizer
      平成24年度日本植物生理学会
    • Place of Presentation
      京都産業大学, 京都市
    • Year and Date
      2012-03-18
    • Related Report
      2013 Final Research Report
  • [Presentation] ニホンナシ黒斑病の病斑拡大におけるエチレンの作用2011

    • Author(s)
      板井章浩
    • Organizer
      植物化学調節学会
    • Place of Presentation
      (宇都宮大学)宇都宮市
    • Year and Date
      2011-11-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] トマトアルターナリア茎枯病菌が保有するconditionally dispensable chromosome (CDC)の構造解析2011

    • Author(s)
      赤木靖典
    • Organizer
      日本植物病理学会関西部会
    • Place of Presentation
      (サンポートホール高松)高松市
    • Year and Date
      2011-11-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] トマトアルターナリア茎枯病菌における global regulator AaLaeAの機能解析2011

    • Author(s)
      高尾和実・ 赤木靖典・ 柘植尚志・ 尾谷浩・ 児玉基一朗
    • Organizer
      平成23年度日本植物病理学会関西部会
    • Place of Presentation
      サンポートホール高松, 高松市
    • Year and Date
      2011-10-01
    • Related Report
      2013 Final Research Report
  • [Presentation] エチレンシグナル経路は Fumonisin B1 によるプログラム細胞死に関与する2011

    • Author(s)
      間瀬圭介・石濱伸明・森仁志・上中弘典・児玉基一朗・吉岡博文
    • Organizer
      平成23年度日本植物病理学会関西部会
    • Place of Presentation
      サンポートホール高松, 高松市
    • Year and Date
      2011-10-01
    • Related Report
      2013 Final Research Report
  • [Presentation] プロピレンと1-MCP処理によるニホンナシ黒斑病の病斑拡大2011

    • Author(s)
      板井章浩
    • Organizer
      園芸学会
    • Place of Presentation
      (岡山大学)岡山市
    • Year and Date
      2011-09-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pathogenicity chromosomes in host-specific toxin-producing Alternaria species2011

    • Author(s)
      Akagi, Y ., Takao, K., Harimoto, Y ., Tsuge, T ., Kodama, M
    • Organizer
      IUMS (International Union of Mycrobiological Societies) 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター, 札幌
    • Year and Date
      2011-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] The structure of the conditionally dispensable chromosome of Alternaria alternata tomato pathotype2011

    • Author(s)
      Akagi, Y.
    • Organizer
      Asian Mycology Congress 2011
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2011-08-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional analysis of a global regulator, LaeA in the fungal plant pathogen Alternaria alternata2011

    • Author(s)
      Takao, K.
    • Organizer
      Asian Mycology Congress 2011
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2011-08-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] The structure of conditionally dispensable chromosome in Alternaria alternata tomato pathotype2011

    • Author(s)
      Akagi, Y ., Tsuge, T . Otani, H. and Kodama, M
    • Organizer
      Asian Mycological Congress 2011
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2011-08-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional analysis of a global regulator , LaeA in the fungal plant pathogen Alternaria alternata2011

    • Author(s)
      Takao, K., Akagi, Y ., Tsuge, T . and Kodama, M
    • Organizer
      Asian Mycological Congress 2011
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2011-08-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Structure of a conditionally dispensable pathogenicity chromosome of the tomato pathotype of Alternaria alternata

    • Author(s)
      Akagi, Y.
    • Organizer
      XV International Congress of Molecular Plant-Microbe Interactions
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 植物病原糸状菌における二次代謝産物生合成と病原性 ―ゲノム解析からみた進化・多様性―

    • Author(s)
      児玉基一朗
    • Organizer
      平成24年度日本植物病理学会感染生理談話会
    • Place of Presentation
      休暇村近江八幡 (滋賀県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] トマトアルターナリア茎枯病菌が保有する病原染色体の構造と機能.

    • Author(s)
      赤木靖典
    • Organizer
      平成24年度日本植物病理学会関西部会
    • Place of Presentation
      とりぎん文化会館 (鳥取県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 植物のプログラム細胞死に関与するAP2/ERF型転写因子であるAtMACD1に制御される遺伝子の探索

    • Author(s)
      間瀬圭介
    • Organizer
      平成24年度日本植物病理学会関西部会
    • Place of Presentation
      とりぎん文化会館 (鳥取県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] LaeA regulate secondary metabolite in multi pathotypes of the fungal plant pathogen Alternaria alternata

    • Author(s)
      Takao, K.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] トマトアルターナリア茎枯病菌が保有する病原性染色体のFISH法による構造解析

    • Author(s)
      赤木靖典
    • Organizer
      日本植物病理学会大会
    • Place of Presentation
      岐阜大学
    • Related Report
      2012 Annual Research Report
  • [Book] Fungal toxins of agricultural importance. In The Mycota2013

    • Author(s)
      Johnson, R.D., Akagi, Y ., Fleetwood, D.J., Gardiner , D.M., Kodama, M., Y oung, C.A., V oisey , C.R.
    • Publisher
      Springer-Verlag, Berlin Heidelberg New York
    • Related Report
      2013 Final Research Report
  • [Book] Fungal toxins of agricultural importance. In The Mycota2013

    • Author(s)
      Johnson,R.D., Akagi,Y., Fleetwood, D.J., Gardiner, D.M., Kodama, M., Young, C.A., Voisey, C.R.
    • Total Pages
      393
    • Publisher
      Springer-Verlag
    • Related Report
      2013 Annual Research Report
  • [Book] The Mycota2013

    • Author(s)
      Johnson,R.D.
    • Publisher
      Springer-Verlag
    • Related Report
      2012 Annual Research Report
  • [Book] 植物-病原微生物の相互作用研究の新展開2012

    • Author(s)
      児玉基一朗
    • Total Pages
      155
    • Publisher
      日本植物病理学会
    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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